Interventional Psychiatry
Road to Novel Therapeutics
- 1st Edition - April 16, 2024
- Editors: Joao L. de Quevedo, André R. Brunoni, Clement Hamani
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 8 4 9 6 - 3
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 8 4 9 7 - 0
Recent advances in pharmacology and brain stimulation have led to the development of novel treatments for psychiatric disorders. These new advances have led to the development of… Read more
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Request a sales quoteRecent advances in pharmacology and brain stimulation have led to the development of novel treatments for psychiatric disorders. These new advances have led to the development of a new subspecialty, Interventional Psychiatry.
Interventional Psychiatry: Road to Novel Therapeutics reviews all specialized treatments including device-based interventions such as electroconvulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS), and deep brain stimulation (DBS). This book discusses the procedure-based pharmacologic interventions including ketamine infusion therapy and psychedelic therapies. Internationally contributed, this book outlines the state of the field, as well as implications for training and the role of the interventional psychiatrist in treatment teams.
- Introduces an innovative approach combining both well-established and innovative methodologies
- Includes an in-depth description of putative mechanisms of action
- Features clinician-friendly presentation of indications, contraindications, and techniques
- Outlines guidelines to foster fellowships in Interventional Psychiatry
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Foreword
- Chapter 1. Interventional therapeutics in psychiatry: Beyond psychopharmacology and psychotherapy?
- Introduction
- Theoretical conceptualization
- Targets and mechanisms of action
- Personalizing treatment
- Challenges for evidence-based medicine
- Training and collaboration
- Perspectives
- Chapter 2. Proposed curriculum for an interventional psychiatry fellowship program
- Background
- The emergence of interventional psychiatry
- Why is it important to have an interventional psychiatry fellowship?
- Overview of current interventional psychiatry training
- Proposed curriculum for an interventional psychiatry fellowship
- Alternatives to an interventional psychiatry fellowship
- Moving toward board certification
- Chapter 3. Mechanisms of action of transcranial magnetic stimulation
- How does TMS work?
- How does TMS depolarize neuronal structures?
- Which neurons are depolarized by TMS?
- TMS effects depend on the state of the neuronal structures
- Possible clinical uses of single- and paired-pulse TMS
- Modulation of cortical responses by repetitive TMS
- Chapter 4. Transcranial magnetic stimulation in psychiatric disorders
- Introduction
- rTMS for major depressive disorder
- rTMS for obsessive-compulsive disorder
- rTMS for other disorders
- Summary
- Chapter 5. Therapeutic use of repetitive transcranial magnetic stimulation (rTMS) in neurological disorders
- Introduction
- Chronic neuropathic pain
- Fibromyalgia
- Other chronic pain syndromes
- Parkinson's disease
- Other movement disorders
- Motor stroke
- Poststroke aphasia
- Poststroke neglect
- Amyotrophic lateral sclerosis
- Multiple sclerosis
- Epilepsy
- Disorders of consciousness
- Cognitive impairment and Alzheimer's disease
- Tinnitus
- Functional neurological disorders
- Conclusion
- Chapter 6. Mechanisms of action of transcranial direct current stimulation
- Introduction
- Neurophysiological effects of tDCS
- tDCS effects on cortical regions other than M1
- The impact of tDCS on brain functional connectivity and topological functional organization
- Non-neuronal effect of tDCS
- Chapter 7. Transcranial direct current stimulation in psychiatric disorders
- Introduction
- Technical aspects
- The clinical uses of tDCS for psychiatric disorders
- Chapter 8. Transcranial Direct Current Stimulation in neurological disorders
- Introduction
- tDCS principles and mechanisms
- tDCS in neurological disorders
- Future directions
- Chapter 9. Mechanism of action of electroconvulsive therapy
- Introduction
- Structural effects
- Functional effects
- Molecular effects
- Conclusion
- Chapter 10. Convulsive therapy for psychiatric disorders
- What is convulsive therapy?
- Modern ECT delivery
- Who is a suitable candidate for ECT?
- Adverse effects of ECT
- How to manage the ECT course
- Comparison of ECT with other interventional psychiatry approaches
- Advances in convulsive therapy
- Conclusion
- Chapter 11. Cognitive effects of convulsive therapies
- Introduction
- Cognitive effects of ECT
- Effects of treatment techniques on cognitive outcomes
- Effects of patient factors on cognitive outcomes
- Monitoring cognition across the ECT treatment course
- Future directions
- Chapter 12. Mechanisms of action of vagus nerve stimulation
- Introduction
- Anatomical and functional pathways of the vagus nerve
- Vagal nerve stimulation
- Mechanism of action of vagal nerve stimulation
- Brain imaging studies
- Conclusion
- Chapter 13. VNS for mood disorders
- Introduction
- Principle of VNS therapy
- Safety and tolerability
- Indications and efficacy
- Patient selection
- Patient education and shared decision-making
- Pathway development
- Summary
- Chapter 14. Ketamine in psychiatry
- Introduction
- The pharmacology of ketamine
- Routes of administration and common formulations
- Moderators/predictors of response
- Continuation/maintenance approaches
- Safety, tolerability, and side effects
- Conclusion
- Chapter 15. Psychedelics in psychiatry
- Serotoninergic psychedelics or classic hallucinogens
- Major depressive disorder
- Cancer-related depression and/or anxiety
- Anxiety disorders
- Substance use disorders
- Other psychiatric disorders
- Possible mechanisms
- Conclusions
- Chapter 16. The use of inhaled gases in psychiatry
- Introduction
- Treatment-resistant major depression
- Nitrous oxide
- Isoflurane
- Xenon
- Chapter 17. Mechanisms of deep brain stimulation for psychiatric disorders
- Introduction
- History of DBS in psychiatry
- Mechanisms of deep brain stimulation: From micro to macro
- Future directions
- Summary
- Chapter 18. Deep brain stimulation for obsessive-compulsive disorder
- Introduction
- Indication for DBS and contraindications
- Deep brain stimulation and procedure
- Targets in deep brain stimulation
- Outcomes of DBS
- Predictors of response
- Neurobiological effects of DBS in OCD patients
- Implementation of DBS in clinical practice
- Discussion
- Chapter 19. Deep brain stimulation for depression
- Introduction
- Psychosurgery
- The modern DBS procedure
- Anatomical targets of DBS for treatment-refractory depression
- Conclusions
- Chapter 20. Radiofrequency lesions for psychiatric disorders
- Introduction
- Historical perspective
- Patient selection
- Radiofrequency lesioning techniques
- Results
- Discussion
- Conclusions
- Chapter 21. Gamma Knife for psychiatric indications
- Background and history
- Main indications
- Neuropsychological and personality aspects
- Radiobiological aspects
- Discussion
- Conclusion
- Chapter 22. Focused ultrasound for psychiatric indications
- Introduction
- Focused ultrasound
- Obsessive-compulsive disorder
- Major depressive disorder
- Limitations and future directions
- Index
- No. of pages: 600
- Language: English
- Edition: 1
- Published: April 16, 2024
- Imprint: Academic Press
- Paperback ISBN: 9780443184963
- eBook ISBN: 9780443184970
JQ
Joao L. de Quevedo
Dr. João Luciano de Quevedo, MD, PhD, is a Professor of Psychiatry at the McGovern Medical School, the University of Texas Health Science Center at Houston, where he is the Vice-Chair for Faculty Development and Outreach, Director of the Translational Psychiatry Program, and Director of the Treatment-Resistant Depression Clinic. Before moving to Houston, he was a Dean at the University of Southern Santa Catarina Medical School, Criciúma, SC, Brazil, where he is still an Adjunct Professor of Psychiatry. He is also Editor-in-Chief of the Brazilian Journal of Psychiatry and Director of the Continuous Medical Education Program in Psychiatry (PROPSIQ) of the Brazilian Psychiatric Association. Dr. Quevedo’s research interest is neurobiology of psychiatric disorders, particularly mood disorders, and he is a specialist in both unipolar and bipolar treatment–resistant depression. He is author of nearly 600 publications and 10 scientific books.
AB
André R. Brunoni
Dr. André Brunoni graduated in Medicine in 2004 and specialized in Internal Medicine and Psychiatry in 2007 and 2010. Dr. Brunoni did his PhD from 2010 to 2012 in the University of São Paulo, Brazil, with a 4-month fellowship at Spaulding Rehabilitation Hospital, Harvard Medical School. Currently, Dr. Brunoni is the Director of two clinical and research centers in leading university hospitals of the University of São Paulo—the Institute of Psychiatry in the Clinics Hospital and the University Hospital. He supervises postgraduate and graduate students as well as medical residents and students. His research involves the use of noninvasive brain stimulation techniques, such as transcranial direct current stimulation, transcranial magnetic stimulation, and “deep” transcranial magnetic stimulation in the treatment of mental disorders, such as mood disorders, obsessive-compulsive disorder, and schizophrenia. He is a very productive and active researcher, with more than 100 published articles in PubMed peer-reviewed journals.
CH
Clement Hamani
Dr. Clement Hamani is the Research Director of the Hurvitz Brain Sciences Program, Senior Scientist at the Sunnybrook Research Institute, Full Professor in Surgery/Neurosurgery at the University of Toronto, preclinical lead of the Harquail Centre for Neuromodulation, and neurosurgeon at the Sunnybrook Health Sciences Centre in Toronto, Canada. Dr. Hamani’s research focus is the development of new ways of modulating the function of the nervous tissue, and discovering new applications for techniques that stimulate the brain and spinal cord to treat neurological and psychiatric disorders. His work ranges from basic research in preclinical models to clinical trials.