International Review of Connective Tissue Research

Contributors Preface

Contents of Previous Volumes

Tentative Contents of Subsequent Volumes

Immunology of Collagen

I. Introduction

II. Collagen Purity and Immunological Specificity

III. Amino Acid Composition and Structure of Collagen

IV. Antigenicity of Collagen and Collagen Derivatives

V. Antigenicity of Synthetic Polypeptides Related to Collagen

VI. Antigenicity of Gelatin and Gelatin Derivatives

VII. Immunological Relationships of Collagen and Other Components of Connective Tissue

VIII. Auto- and Isoantibodies to Collagen in Diseases of Connective Tissue

IX. Pathogenicity of Anticollagen Antibodies

X. Summary and Conclusions

References

Collagen Biosynthesis at the Ribosomal Level

I. Collagen-Nucleic Acid Complexes

II. Ribonucleic Acid and Collagen Synthesis

III. Collagen Formation on Polyribosomes

IV. Messenger Ribonucleic Acid

V. The Substrate for Hydroxylation

References

Control of Collagen Biosynthesis

Introduction

I. Conditions for the Specific Control of Biosynthesis of Collagenous Proteins

II. Relation of Intermediary Metabolism to Collagen Synthesis

III. Effect of Proline, Its Analogs, and Other Amino Acids on Collagen Protein Synthesis

IV. Antibiotics and Collagen Synthesis

V. Metals and Collagen Synthesis

VI. Effect of Chelating Agents

VII. Hydroxyproline- and Hydroxylysine-Deficient Collagen

VIII. Collagen Hydroxylase

IX. Ascorbic Acid as the Factor Controlling Protein Synthesis

X. Influence of the Partial Tension of Oxygen

XI. Further Reagents Controlling Collagen Formation

XII. Conclusion

XIII. Appendix: Formulas of Substances Discussed

References

Copper and Connective Tissue Metabolism

I. Introduction

II. The Metabolic Role of Copper

III. The Connective Tissues in Copper Deficiency

IV. Biogenesis of Connective Tissues

V. Relation of Copper to Connective Tissue Metabolism

References

Effect of Ionizing Radiation on Connective Tissue Components

I. Introduction

II. Interaction of Ionizing Radiation with Matter

III. Irradiation of Fibrous Connective Tissue

IV. Irradiation of Ground Substance

V. Irradiation of Cellular Components

VI. Aging and Radiation

VII. Chemical Protection of Tissues against Radiation

VIII. Concluding Remarks

References

Physical Properties of Collagen Fibers

I. Introduction

II. Crystalline Collagen

III. Hydration

IV. Mechanical Properties

V. Noncrystalline Collagen

VI. Summary

References

Author Index

Subject Index