International Review of Cell and Molecular Biology

Chapter One. Epidermal Growth Factor Signaling in Transformed Cells

• 1. Introduction
• 2. Hallmarks of Transformation
• 3. The ErbB/HER Receptor Family in Normal and Transformed Cells
• 4. EGFR Signaling in Normal and Transformed Cells
• 5. Cross Talk between EGFR Signaling and Other Major Signaling Pathways in Transformed Cells
• 6. Therapy
• 7. Concluding Remarks

Chapter Two. New Insights into Antimetastatic and Antiangiogenic Effects of Cannabinoids

• 1. Introduction
• 2. Cannabinoids as Systemic Anticancer Drugs
• 3. Cannabinoids and Tumor Angiogenesis
• 4. Effects of Cannabinoids on Tumor Cell Metastasis
• 5. Conclusion

Chapter Three. Insight into the Role of Wnt5a-Induced Signaling in Normal and Cancer Cells

• 1. Introduction
• 2. Wnt5a–Ror2 Axis in Developmental Morphogenesis
• 3. Roles of Wnt5a–Ror2 Axis in Normal Cell Functions
• 4. Wnt5a–Ror2 and Ror1 Axes in Cancer Cells
• 5. Concluding Remarks

Chapter Four. New Insight into Cancer Aneuploidy in Zebrafish

• 1. Introduction
• 2. The Cause of Aneuploidy
• 3. Biological Effects of Aneuploidy
• 4. Zebrafish as a Cancer Model for Human Cancers
• 5. Cancer Driver Genes on Aneuploid Chromosomes
• 6. Future Directions

Chapter Five. The Amazing Ubiquitin-Proteasome System: Structural Components and Implication in Aging

• 1. Introduction
• 2. Aging
• 3. The Ubiquitin System
• 4. The Proteasome
• 5. Regulation of the Ub System during Cellular Senescence and In vivo Aging
• 6. Implication of ERAD and OMMAD in Cellular Senescence and In vivo Aging
• 7. Alterations of the Proteasome Functionality during Cellular Senescence and In vivo Aging
• 8. Modulation of the UPS as an Antiaging Approach
• 9. Conclusive Remarks and Perspectives

Chapter Six. Biogenesis and Function of the NGF/TrkA Signaling Endosome

• 1. Introduction
• 2. NGF
• 3. TrkA
• 4. The Signaling Endosome
• 5. Concluding Remarks

Chapter Seven. Multiple Myeloma as a Model for the Role of Bone Marrow Niches in the Control of Angiogenesis

• 1. Introduction
• 2. EPCs and MSCs
• 3. Vascular Niche
• 4. Osteoblastic Niche
• 5. MM Niche and Angiogenesis
• 6. Targeting Angiogenesis in the MM Niche
• 7. Concluding Remarks