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Elsevier

Intercellular Signaling in Development and Disease

Cell Signaling Collection

  • 1st Edition - April 5, 2011
  • Latest edition
  • Editors: Edward A. Dennis, Ralph A. Bradshaw
  • Language: English

Required reading for anyone involved in cell signaling research with articles written and edited by experts in the field. This title covers disease states such as lymphoid… Read more

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Description

Required reading for anyone involved in cell signaling research with articles written and edited by experts in the field. This title covers disease states such as lymphoid leukemia, breast cancer, pulmonary fibrosis, systemic sclerosis, andinflammatory bowel disease, along with up-to-date research on signaling systems and mutations intranscription factors that provide new targets for treating disease.

Key features

  • Articles written and edited by experts in the field
  • Thematic volume covering disease states such as lymphoid leukemia, breast cancer, pulmonary fibrosis, systemic sclerosis, and inflammatory bowel disease
  • Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease

Readership

Professionals, researchers and graduate students in molecular biology, biochemistry, cell biology, biomedicine, structural biology, systems biology, and genetics

Table of contents

The fourth volume includes chapters 294 to 340

Signaling From Intracellular Compartments

294 . Protein Quality Control in the Endoplasmic Reticulum

295 . Quality Control and Quality Assurance in the Mitochondrion

296 . Protein Quality Control in Peroxisomes: Ubiquitination of the Peroxisomal Targeting Signal Receptors

297 . Mitochondrial Dynamics: Fusion and Division

298 . The SREBP Pathway: Gene Regulation through Sterol Sensing and Gated Protein Trafficking

299 . Regulating Endoplasmic Reticulum Function through the Unfolded Protein Response

300 . Signaling Pathways from Mitochondria to the Cytoplasm and Nucleus

301 . Apoptosis Signaling: A Means to an End

302 . Regulation of Cell Cycle Progression

303 . Signaling During Organelle Division and Inheritance: Peroxisomes

304 . Signaling at the Nuclear Envelope

305 . Bidirectional Crosstalk between Actin Dynamics and Endocytosis

306 . Signaling in Autophagy Related Pathways

Cell -Cell and Cell-Matrix Interaction

307 . Overview of Cell – Cell and Cell – Matrix Interactions

308 . Interactive Signaling Pathways in the Vasculature

309 . Signaling Pathways Involved in Cardiogenesis

310 . Regulatory Signaling in Pancreatic Organogenesis: Implications for Aberrant Signaling in Pancreatic Cancer

311 . Trophic Effects of Gut Hormones in the Gastrointestinal Tract

312 . The Neurotrophin Factors

313 . Cell to Cell and Cell-Matrix Interactions in Bone

314 . Cell-Cell Signaling in the Testis and Ovary

315 . Signal Transduction in T Lymphocytes

316 . Signal Transduction via the B Cell Antigen Receptor: A Crucial Regulator of B Cell Biology

317 . Signaling Pathways in the Normal and Neoplastic Breast

318 . Kidney

319 . Cytokines and Cytokine Receptors Regulating Cell Survival, Proliferation, and Differentiation in Hematopoiesis

320 . Signaling Pathways Regulating Growth and Differentiation of Adult Stem Cells

321 . In Vivo Imaging of Cellular Network Signaling

DISEASE PATHOPHYSIOLOGY: Translational Implications

322 . The Roles of Ras Family Small GTPases in Breast Cancer

323 . Translational Implications of Stromal–Epithelial Interactions in Prostate Cancer and the Potential Role of Prostate Cancer Stem/Progenitor Cells

324 . Aberrant Signaling Pathways in Pancreatic Cancer: Opportunities for Targeted Therapeutics

325 . The Evolution and Maintenance of the Multiple Myeloma Cell Clone within the Liquid Bone Marrow Compartment: Therapeutic Implications

326 . The Pathophysiologic Role of the Bone Marrow Environment and its Niches in Multiple Myeloma

327 . Signaling Targets in Myeloid Leukemias

328 . Signaling Targets in Lymphoid Leukemias

329 . Targeting Ras for Anticancer Drug Discovery

330 . Targeting EWS/FLI1 Driven Signaling Pathways as Therapy for Tumors of the Ewing’s Sarcoma Family

331 . IRS-Protein Scaffolds and Insulin/IGF Action in Central and Peripheral Tissues

332 . Adipokine Signaling: Implications for Obesity

333 . Angiogenesis Signaling Pathways as Targets in Cancer Therapy

334 . CXC Chemokine Signaling in Interstitial Lung Diseases

335 . Systemic Sclerosis

336 . Signal Transduction in Rheumatoid Arthritis and Systemic Lupus Erythematosus

337 . Translational Concepts in Vasculitis

338 . Advances in Understanding the Pathogenesis of Infl ammatory Bowel Disease

339 . Translational Implications of Proteomics

340 . Translational Implications of microRNAs in Clinical Diagnostics and Therapeutics

Review quotes

"The Cell Signaling Collection consists of four independent volumes which reprint articles from the second edition of the carefully selected to alert medical and biological scientists to recent developments in the study of cellular signaling. This volume contains 57 articles exploring transduction mechanisms. After an overview of intracellular signaling, they cover phosporylation and dephosphorylation in kinases and phosphates, lipid signaling, cyclic nucleotides, and G proteins. The other volumes cover the functioning of transmembrane receptors, the regulation of organelle and cell compartment signaling, and intracellular signaling in development and disease."—Reference and Research Book News

"For professionals, graduate researchers, and graduate students in biochemistry, biology, genetics, and biomedicine, Dennis (chemistry and biochemistry and pharmacology, U. of California, San Diego) and Bradshaw (chemistry and pharmaceutical chemistry, U. of California, San Francisco) bring together 52 articles from the authors' on cell-cell signaling, signaling development, and signaling in disease. A group of biologists, chemists, oncologists, surgeons, and other scientists from the US, Europe, Singapore, and Australia emphasize the role of cell-cell interaction and organ and tissue effects in signaling activities and their disease implications. They do not cover other aspects of cell signaling like transmembrane receptor structure, receptor organization and function, intracellular signaling mechanisms, and transcriptional activation and responses in other organelles."—Reference and Research Book News

Product details

  • Edition: 1
  • Latest edition
  • Published: April 5, 2011
  • Language: English

About the editors

ED

Edward A. Dennis

Edward A. Dennis is Distinguished Professor and former Chair of the Department of Chemistry and Biochemistry and Professor in the Department of Pharmacology in the School of Medicine at the University of California, San Diego. He is also Editor-in-Chief of the Journal of Lipid Research.
Affiliations and expertise
Department of Chemistry and Biochemistry and Department of Pharmacology in the School of Medicine at the University of California, San Diego

RB

Ralph A. Bradshaw

Ralph A. Bradshaw is Professor Emeritus in the Department of Physiology and Biophysics at the University of California, Irvine. Prior to that he was on the faculty of the Department of Biological Chemistry, Washington University, and Professor and Chair of the Department of Biological Chemistry, University of California Irvine. He presently is Professor of Pharmacology at the University of California, San Diego. He served as president of FASEB, was the founding president of the Protein Society and was the treasurer of the ASBMB. He was the founding editor of Molecular and Cellular Proteomics. His research has focused on protein chemistry and proteomics, with emphasis on the structure and function of growth factors and their receptors, particularly nerve growth factor and fibroblast growth factor, and the involvement of receptor tyrosine kinases in cell signaling. He has also studied the role of proteolytic processing and N-terminal modification in protein stability and turnover.
Affiliations and expertise
Department of Chemistry and Pharmaceutical Chemistry; and Mass Spectrometry Facility, University of California, San Francisco, Department of Physiology and Biophysics, College of Medicine, University of California, Irvine, Irvine, CA, USA