Inter-Organellar Ca2+ Signaling in Health and Disease - Part A

1st Edition, Volume 362 - July 7, 2021
Imprint: Academic Press
Editors: Lorenzo Galluzzi, Saverio Marchi
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 2 4 0 3 4 - 2
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 4 0 3 5 - 9

Inter-Organellar Ca2+ Signaling in Health and Disease - Part A, Volume 362, the latest release in the International Review of Cell and Molecular Biology series, highlights new adva… Read more

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Inter-Organellar Ca2+ Signaling in Health and Disease - Part A, Volume 362, the latest release in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface: Ca2 + in health and disease
Chapter One: Calcium signaling in neuroglia
Abstract
1: Introduction: Supportive and protective neuroglia
2: Glial cells
3: Astrocytic Ca2+ signaling
4: Ca2+ signaling in oligodendrocytes
5: Ca2+ signaling in microglia
6: Conclusions
Acknowledgments
Chapter Two: Ca2 + homeostasis in brain microvascular endothelial cells
Abstract
1: Introduction
2: Calcium measurements in brain microvascular endothelial cells
3: Ion channels/receptors regulating Ca2 + homeostasis in brain microvascular endothelial cells
4: Ca2+ homeostasis and cytoskeleton organization in the blood brain barrier
5: Alterations of Ca2 + homeostasis in the blood brain barrier associated with neuropathologies
6: Opening of the blood brain barrier and its role in CNS chemotherapy
Acknowledgments
Chapter Three: Mitochondrial calcium homeostasis in hematopoietic stem cell: Molecular regulation of quiescence, function, and differentiation
Abstract
1: Introduction
2: Intracellular Ca2 + homeostasis in HSC maintenance and commitment
3: Mitochondrial calcium in HSC regulation
4: Calcium homeostasis deregulation in malignant hematopoiesis
5: Conclusion
Chapter Four: Lysosomal calcium and autophagy
Abstract
1: Introduction
2: Endolysosomal calcium channels
3: Two-pore channels (TPCs)
4: Two-pore channels (TPCs) and autophagy pathway
5: TRPMLs
6: TRPML1 and autophagy
7: TRPML1 and chaperone-mediated autophagy (CMA)
8: TRPML3 and autophagy
9: Lysosomal calcium and selective autophagy
10: Concluding remarks
Acknowledgments
Chapter Five: Mitochondrial Ca2 + and cell cycle regulation
Abstract
1: Introduction
2: Cytosolic calcium signaling during the cell cycle
3: Mitochondrial Ca2 + uniporter complex (MCUC) and its regulatory mechanisms
4: Mitochondrial calcium signaling during the cell cycle
5: The mitochondrial calcium uptake mechanism
6: Mitochondrial Ca2 + dependent cell cycle regulation in tumorigenesis
7: Conclusions
Chapter Six: The mitochondrial calcium homeostasis orchestra plays its symphony: Skeletal muscle is the guest of honor
Abstract
1: Introduction
2: Physiological roles of mitochondrial calcium uptake
3: Calcium transport through the outer mitochondrial membrane
4: Calcium transport through the inner mitochondrial membrane
5: The mitochondrial calcium uniporter complex
6: Mitochondrial calcium extrusion
7: Mitochondrial calcium uptake and ROS production
8: Mitochondrial calcium accumulation and cell death
9: Ca2 + in skeletal muscle: a bidirectional signaling route
10: The role of mitochondrial bioenergetics in the control of skeletal muscle function
11: Skeletal muscle mitochondrial biogenesis: A nuclear receptor network controls mitochondrial respiratory function and fuel selection
12: Impairment of Ca2 + homeostasis and mitochondrial Ca2 + signaling in muscular dystrophy
13: Ryanodine receptor myopathies: Neuromuscular disorders affecting EC coupling and Ca2 + homeostasis
Chapter Seven: Mitochondrial Ca2+ homeostasis in trypanosomes
Abstract
1: Introduction
2: The mitochondrial Ca2+ uniporter: Discovery
3: The mitochondrial Ca2+ uniporter of trypanosomes: The pore subunits
4: The mitochondrial Ca2+ uniporter of trypanosomes: The gatekeeper subunits
5: The mitochondrial Ca2+ uniporter of trypanosomes: Interaction with the ATP synthase
6: Mechanism of mitochondrial Ca2+ efflux in trypanosomes
7: Role of mitochondrial Ca2+ uptake
8: Conclusions and open questions
Acknowledgments

Lorenzo Galluzzi

Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology. Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.

Affiliations and expertise

Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USA

Saverio Marchi

Saverio Marchi obtained his PhD in ‘Pharmacology and Molecular Oncology’ from University of Ferrara (Italy), under the supervision of Prof. Rosario Rizzuto, where he investigated the role of Ca2+ signalling and mitochondrial dynamics in cancer. He did a short term research stay at the Gustave Roussy Institute (Paris, France) in the Guido Kroemer’s lab, for the study of the mechanisms of autophagy regulation. On 2011 he joined the Laboratory of Dr. Paolo Pinton at the University of Ferrara (Italy) where he carried out his postdoctoral studies. During his postdoctoral training, he studied the implications of Endoplasmic Reticulum-mitochondria connection in diseases, especially cancer. In 2014, he was the recipient of the Young Researcher award, which allowed him to work at the Cancer Center, University of Hawai’i (Prof. Michele Carbone’s lab), where he was introduced to the study of the signalling pathways regulating mesothelioma progression. Now, he is associate professor at the Marche Polytechnic University, where he leads his own group. He is interested in the involvement of the MCU complex and mitochondrial Ca2+ in the evolution of cancer. More recently, he has become interested in the alteration of mitochondrial dynamics during bacterial infection. He published 77 papers on “peer-reviewed” journals (h-index: 41; n° of citations > 5800. Source: Scopus).

Affiliations and expertise

Dept. of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

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