Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells

Chapter One. Luminescent Zinc Complexes as Bioprobes for Imaging Molecular Events in Live Cells

• 1. Introduction
• 2. General Considerations
• 3. Luminescent Zinc Complexes as Bioprobes
• 4. Conclusion and Outlook

Chapter Two. Cellular Uptake and Sensing Capability of Transition Metal Peptide Conjugates

• 1. Introduction
• 2. Transition Metal Complexes for Cell Imaging and Sensing
• 3. Cell-Penetrating Peptides
• 4. Mechanism of CPP Uptake
• 5. CPP Modified Transition Metal Luminophores for Sensing and Imaging
• 6. Signal Peptide-Modified Transition Metal Luminophores
• 7. Conclusions and Future Outlook

Chapter Three. Luminescent Rhenium(I) and Iridium(III) Complexes for Intracellular Labeling, Sensing, and Photodynamic Therapy Applications

• 1. Introduction
• 2. Intracellular Labels
• 3. Intracellular Sensors
• 4. Ratiometric Sensors
• 5. Photodynamic Therapy
• 6. Conclusion

Chapter Four. Organoruthenium(II)-Arene Complexes: Structural Building Blocks for Anticancer Drug Discovery

• 1. Introduction
• 2. Accessing the Ruthenium(II)-Arene Scaffold
• 3. Ru(II)-Arene Drug Candidates Under Investigation
• 4. Cytotoxic Ru(II)-Arene Complexes via Classical Approaches
• 5. Nonclassical Ru(II)-Arene Complexes by Rational Design
• 6. Nonclassical Ru(II)-Arene Complexes From Classical Approaches
• 7. Conclusion

Chapter Five. Medicinal Chemistry of Metal N-Heterocyclic Carbene (NHC) Complexes

• 1. Introduction
• 2. Metal NHC Complexes With Classical N–C–N Carbene Ligands
• 3. Metal NHC Complexes With “Nonclassical” NHC Ligands and Heterobimetallic Metal NHC Complexes
• 4. Metal NHC Complexes With Biologically Active, Biogenic, or Targeting Ligands
• 5. Conclusions

Chapter Six. Metal Complexes as Delivery Systems for CO, NO, and H₂S to Explore the Signaling Network of Small-Molecule Messengers

• 1. Introduction
• 2. Enzymatic Generation of CO, NO, and H₂S
• 3. Delivery Systems for CO, NO, and H₂S
• 4. Molecular Probes for Small-Molecule Messengers
• 5. Cellular Target Structures of CO, NO, and H₂S
• 6. Summary

Chapter Seven. Antimicrobial Metallodrugs

• 1. Introduction
• 2. Redox-Active Metal Complexes
• 3. Complexes With Reactive Metal Centers
• 4. Complexes That Release Carbon Monoxide
• 5. Metal Centers as Structural Templates
• 6. Outlook

Chapter Eight. Carbon Nanotubes and Related Nanohybrids Incorporating Inorganic Transition Metal Compounds and Radioactive Species as Synthetic Scaffolds for Nanomedicine Design

• 1. Introduction
• 2. Positron Emission Tomography–Single-Photon Emission Computed Tomography Metal Complex Bioconjugates
• 3. Potential Application of Carbon Nanomaterial Nanohybrids Incorporating Inorganic Transition Metal Complexes in Biomedical Applications
• 4. Conclusions and Future Prospects

Chapter Nine. Immobilized Metal Affinity Chromatography (IMAC) for Metalloproteomics and Phosphoproteomics

• 1. Introduction
• 2. Principles and Design of Immobilized Metal Affinity Chromatography Columns
• 3. Immobilized Metal Affinity Chromatography for Metalloproteomic Study
• 4. Immobilized Metal Affinity Chromatography for the Analysis of Protein Phosphorylation
• 5. Novel Polymer-Based Metal Ion Affinity Capture: Alternative to Immobilized Metal Affinity Chromatography
• 6. Conclusion

Chapter Ten. The Analysis of Therapeutic Metal Complexes and Their Biomolecular Interactions

• 1. Introduction
• 2. Metallodrug Binding to Blood Serum Proteins
• 3. Tissue Distribution and Cellular Accumulation
• 4. Cellular Targets
• 5. Conclusions