Inherited cardiac diseases predisposing to sudden death, An Issue of Cardiac Electrophysiology Clinics

1st Edition, Volume 15-3 - August 11, 2023
Editors: Rafik Tadros, Julia Cadrin-Tourigny, Jason Roberts
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 3 3 4 - 8
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 3 3 5 - 5

In this issue of Cardiac Electrophysiology Clinics, guest editors Drs. Rafik Tadros, Julia Cadrin-Tourigny, and Jason D. Roberts bring their considerable expertise to the topic of… Read more

Inherited cardiac diseases predisposing to sudden death, An Issue of Cardiac Electrophysiology Clinics

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In this issue of Cardiac Electrophysiology Clinics, guest editors Drs. Rafik Tadros, Julia Cadrin-Tourigny, and Jason D. Roberts bring their considerable expertise to the topic of Inherited Cardiac Diseases Predisposing to Sudden Death. Top experts in the field cover key topics such as genetic counseling and genetic testing in inherited heart disease; implantable devices in genetic heart disease; gene-based therapy in inherited arrythmias and cardiomyopathies; personalized care in long QT syndrome; and more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Foreword
Preface
Introduction
Principles of Genetic Counseling in Inherited Heart Conditions
Key points
Introduction
Discussion
Future directions
Summary
Clinics care points
Disclosure
A Practical Guide to Genetic Testing in Inherited Heart Disease
Key points
Introduction
Discussion
Summary
Clinics care points
Disclosure
Implantable Devices in Genetic Heart Disease: Disease-Specific Device Selection and Programming
Key points
Introduction
Catecholaminergic polymorphic ventricular tachycardia
Arrhythmogenic cardiomyopathy
Hypertrophic cardiomyopathy
Brugada syndrome
Congenital long QT syndrome
Idiopathic ventricular fibrillation
Short QT syndrome
Summary
Clinics care points
Disclosure
Emerging Targeted Therapies for Inherited Cardiomyopathies and Arrhythmias
Key points
Introduction
Hypertrophic cardiomyopathy
Arrhythmogenic right ventricular cardiomyopathy
Catecholaminergic polymorphic ventricular tachycardia
Inherited dilated cardiomyopathies
Danon disease
Gene editing
Summary
Disclosures
Novelties in Brugada Syndrome: Complex Genetics, Risk Stratification, and Catheter Ablation
Key points
Introduction
Genetics
Pathophysiology
Diagnosis
Risk stratification
Management
Catheter ablation
Summary
Clinics care points
Disclosure
Personalized Care in Long QT Syndrome: Better Management, More Sports, and Fewer Devices
Key points
Introduction
The Genetics
Risk prediction
Management
Summary
Clinics care points
Catecholaminergic Polymorphic Ventricular Tachycardia: A Review of Therapeutic Strategies
Key points
Introduction
General treatment considerations
Lifestyle modifications
Pharmacological therapy
Nonpharmacological therapy
Our recommended chronic treatment algorithm
Acute management of ventricular arrhythmias
Management of atrial arrhythmias
Drug-induced catecholaminergic polymorphic ventricular tachycardia
Trial design issues
Summary
Clinics care points
Conflict of interest
Funding
Investigation of Unexplained Cardiac Arrest: Phenotyping and Genetic Testing
Key points
Introduction
Diagnostic tests
Causes of unexplained cardiac arrest
Approach to patients with unexplained cardiac arrest
Clinics care points
Disclosure
Funding
Calcium Release Deficiency Syndrome: A New Inherited Arrhythmia Syndrome
Key points
Introduction
Molecular Mechanism: CRDS versus CPVT
Presentations and Symptoms: CRDS versus CPVT
Diagnostic Considerations in CRDS
Therapeutic Options
Areas of Future Research
Summary
Clinics Care Points
Disclosures
Short-Coupled Ventricular Fibrillation
Key points
Introduction and definition
Clinical manifestations and electrophysiology of short-coupled ventricular fibrillation
Molecular and genetic aspects of short-coupled ventricular fibrillation
Diagnosis
Management and follow-up
Future directions
Clinics care points
Funding
The Novel Familial ST-Depression Syndrome – Current Knowledge and Perspectives
Key points
Introduction
Epidemiology
Diagnosis
Arrhythmias
Left ventricular systolic dysfunction
Clinical management
Inheritance and genetics
Perspectives
Clinics care points
Disclosures
Prevention of Sudden Death and Management of Ventricular Arrhythmias in Arrhythmogenic Cardiomyopathy
Key points
Introduction
Arrhythmogenic cardiomyopathy: an overview
Treatment
Prevention of sudden cardiac death: the importance of risk stratification
Summary
Clinics care points
Disclosure
Sudden Death Risk Assessment in Hypertrophic Cardiomyopathy Across the Lifespan: Reconciling the American and European Approaches
Key points
Introduction
Traditional stand-alone risk factors
European approach: the HCM Risk-SCD
Novel Stand-Alone Risk Factors
Practical guidance for implantable cardioverter-defibrillators indications in hypertrophic cardiomyopathy
Specific populations
Current recommendations and unmet needs
Clinics care points
Funding sources
Disclosures
Impact of Cardiac Magnetic Resonance to Arrhythmic Risk Stratification in Nonischemic Cardiomyopathy
Key points
Introduction
Nonischemic cardiomyopathy: definitions and epidemiology
Sudden cardiac death in nonischemic cardiomyopathy
Limitations of traditional risk stratification
Characteristics of the ideal predictor of sudden cardiac death
Pathophysiology of ventricular arrhythmia
Late gadolinium enhancement presence/absence and the arrhythmic risk
Late gadolinium enhancement presence/absence and survival benefit with implantable cardioverter defibrillator (including cardiac resynchronization therapy associated with an ICD)
Late gadolinium enhancement extent and the arrhythmic risk
Late gadolinium enhancement location/pattern and the arrhythmic risk
Limitations of late gadolinium enhancement
T1 maps/extracellular volume fraction and the risk of ventricular arrhythmia/sudden cardiac death
Other cardiac magnetic resonance parameters
Interaction between late gadolinium enhancement and genotype
Current European society of cardiology guidelines
Recommendations for future studies
Summary
Clinics care points
Genetic Risk Stratification in Arrhythmogenic Left Ventricular Cardiomyopathy
Key points
Introduction
Desmoplakin
Lamin A/C
Filamin C
Phospholamban
RNA-binding motif protein 20
Transmembrane protein 43
Channelopathies
Summary and future directions
Disclosure

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Inherited cardiac diseases predisposing to sudden death, An Issue of Cardiac Electrophysiology Clinics

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Rafik Tadros

Julia Cadrin-Tourigny