Inflammation and Oral Cancer
From Bench to Bedside
- 1st Edition - September 1, 2021
- Imprint: Academic Press
- Editor: Hiroyuki Tomita
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 8 5 2 6 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 8 5 2 7 - 0
Inflammation and Oral Cancer: From Bench to Bedside discusses all aspects surrounding the relationship between inflammation and oral cancer, from basic science to the translati… Read more
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Request a sales quoteInflammation and Oral Cancer: From Bench to Bedside discusses all aspects surrounding the relationship between inflammation and oral cancer, from basic science to the translational research that helps in the optimization of clinical management strategies. The book discusses topics such as chronic inflammation and cancer in oral cavity, the role of HPV in oral inflammation and cancer, rodent models of oral cancer, and epigenetics in oral inflammation and cancer. This is a valuable resource for cancer researchers, oncologists and members of biomedical field who are interested in learning more about the diverse aspects of inflammation and oral cancer.
Inflammation in oral mucosa can remodel the topography of the overlying epithelium. If such inflammation is chronic, it can have fundamental clinical consequences, the principal of which can be premalignant lesions throughout the alimentary tract. Furthermore, mucosal inflammation, even if subtle, is the single most common pathway for oral cancer - therefore it is very important to understand these interactions in detail.
- Presents animal models of oral cancers for use in research
- Discusses epigenetics in oral cancers, along with risk factors such as tabaco and alcohol
- Encompasses detailed information on human papilloma virus (HPV) and its risk in oral inflammation and cancer
Cancer researchers; oncologists; clinicians
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter 1: Epidemiology of oral cancer and its relationship with inflammation
- Abstract
- 1: Introduction
- 2: Oral anatomy and favorite site
- 3: Histological type
- 4: Age and sex
- 5: Incidence and mortality
- 6: Risk factors
- 7: Genetic mutation and signal transduction
- 8: Inflammation and cancer
- Chapter 2: Diagnosis of oral squamous cell carcinomas and precancerous lesions
- Abstract
- 1: Introduction
- 2: OPMDs
- 3: Oral epithelial dysplasia
- 4: Oral cancer
- 5: Subtype of oral SCC
- 6: Conclusion
- Chapter 3: Oral cytology in Japan: Its useful approach and criteria for early detection of carcinoma and precursor lesions
- Abstract
- 1: Introduction
- 2: Procedure of cell collection
- 3: The guideline diagnostic criteria for oral mucosal exfoliative cytology (OMEC)
- 4: Appropriate evaluation of specimens
- 5: Cytological classification
- Chapter 4: Imaging findings of oral cancers
- Abstract
- 1: Introduction
- 2: Anatomy of the oral cavity
- 3: Staging of oral cancer
- 4: Imaging modalities and protocols in oral cancer
- 5: Imaging findings of oral cancer at each subsite
- 6: Patterns of spread of oral cancer
- 7: Conclusion
- Chapter 5: What is epigenetics?
- Abstract
- 1: Foreword
- 2: Methylation modification of DNA
- 3: Writing with DNA methyltransferases
- 4: Reversibility of methylation
- 5: DNA methylation in cancer
- 6: CpG island standards
- 7: Activation of oncogenes
- 8: Silencing of tumor suppressor genes
- 9: Causes of methylation abnormalities (Fig. 3)
- 10: Methylation detection methods (Fig. 4)
- 11: Methylation of various carcinomas
- 12: Possibility of application in cancer treatment
- 13: Hypermethylation detection in blood and body fluids and assay methods for clinical application
- 14: Toward the realization of methylation therapies
- 15: Oral cancer treatment
- 16: Future perspectives
- Chapter 6: Role of autophagy in dysregulation of oral mucosal homeostasis
- Abstract
- 1: Introduction
- 2: Oral mucosal homeostasis
- 3: Autophagy
- 4: Effect of autophagy on oral infection
- 5: Effect of autophagy on aging and cellular senescence
- 6: Autophagy in cancer
- 7: Conclusion
- Chapter 7: Oral mucosal graft-versus-host disease and its possibility of antitumor effects
- Abstract
- 1: Introduction
- 2: What is GVHD?
- 3: Oral GVHD
- 4: Immunopathophysiology of oral GVHD
- 5: Graft-versus-tumor as antitumor effect of GVHD in oral squamous cell carcinoma
- 6: Conclusion
- Chapter 8: Standardization of sentinel lymph node biopsy in oral cancer
- Abstract
- 1: Introduction
- 2: Identification of sentinel lymph nodes
- 3: Methods for the diagnosis of sentinel lymph node metastasis
- 4: Evidence-based medicine applied to sentinel lymph node biopsy (SLNB)
- 5: Summary
- Chapter 9: Overview of radiotherapy for oral cavity cancer
- Abstract
- 1: Introduction
- 2: General principles
- 3: Radiation technique
- 4: Conclusion
- Chapter 10: Management of cancer treatment-induced oral mucositis
- Abstract
- 1: Introduction
- 2: Frequency of oral mucositis
- 3: Pathogenesis of anticancer agent and radiotherapy-induced oral mucositis
- 4: Management of oral mucositis
- 5: Effect of polaprezinc on chemotherapy- and/or radiotherapy-induced oral mucositis
- Chapter 11: Perspectives in research on oral squamous cell carcinoma
- Abstract
- Index
- Edition: 1
- Published: September 1, 2021
- No. of pages (Paperback): 224
- No. of pages (eBook): 224
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323885263
- eBook ISBN: 9780323885270
HT
Hiroyuki Tomita
Hiroyuki Tomita, MD, PhD, is Associate Professor at the Department of Tumor Pathology, Gifu University Graduate School of Medicine. Dr. Tomita is a certificated pathologist and have published research and review articles in the basic and clinical of head and neck cancers throughput his career.
Affiliations and expertise
Associate Professor, Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, JapanRead Inflammation and Oral Cancer on ScienceDirect