Inflammation, Advancing Age and Nutrition
Research and Clinical Interventions
- 1st Edition - October 3, 2013
- Latest edition
- Editors: Irfan Rahman, Debasis Bagchi
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 3 9 7 8 0 3 - 5
- eBook ISBN:9 7 8 - 0 - 1 2 - 3 9 7 8 0 7 - 3
The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle in… Read more
The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine. This book is a valuable resource for health professionals, scientists and researchers, nutritionists, health practitioners, students and for all those who wish to broaden their knowledge in the allied field.
- Includes models of aging, including worm, mouse and human
- Explores the relationship of inflammation with diseases, including ocular health, Alzheimer's and Parkinson's disease, and muscle health
- Encompasses a variety of lifestyle impacts, including diet, exercise and nutrition
- Includes suggested nutritional interventions
Researchers, scientists and physicians specializing in arthritis, obesity, diabetes, hypertension, osteoporosis and osteoarthritis, and cardiovascular fields. Gerontologists and Geriatricians. Nutritionists and Dieticians.
Dedication
Biography
Preface
Contributors
Chapter 1. Biomarkers and Inflammatory Network in Aging: Targets for Therapies
Abstract
Introduction
Aging Biomarkers: Definition and Selection Criteria
Inflammatory Network: A Description and its Biological Effects on Aging
Cellular Inflammatory Biomarkers
Serum Inflammatory Biomarkers
Molecules and Mechanisms Linked to THE NF-κB Signaling System are Potential Targets for Anti-Aging and Anti-Age-Related Disease Treatment Strategies
Conclusions
References
Chapter 2. The Biological Significance of Zinc in Inflammation and Aging
Abstract
Acknowledgments
Introduction
Inflammation, Cellular and Tissue Damage, and Chronic Disease
Reactive Oxygen Species and their Physiological Roles
Reactive Oxygen Species and Cell or Tissue Injury
The Biology of Aging
Aging, Inflammation, Oxidative Stress, and Dna Damage
The Biological Functions of Zinc
The Role of Zinc as an Anti-Inflammatory Agent
Zinc as an Antioxidant Agent
The Molecular Link Between NF-κB, A20, Zinc, And Cancer
The Role of Zinc in The Regulation of Nrf2, Aging, and Cancer
The Role of Zinc in the Regulation of p53 and Cancer
Conclusions and Perspectives
References
Chapter 3. Immunity, Inflammation, and Aging
Abstract
Introduction
Aging and Immune System Remodeling
Aging and Inflammation
Summary and Conclusions
References
Chapter 4. Oxidative Stress, Inflammaging, and Immunosenescence
Abstract
Introduction
Inflammaging
Roles of Oxidative and Inflammatory Stress in Immunosenescence
The Oxidation-Inflammation Theory of Aging
Role of Antioxidants in the Immune System
Chronic Stress Leads to Premature Immunosenescence and Increased Inflammaging
Conclusions
References
Chapter 5. Stress Response, Inflammaging, and Cancer
Abstract
Introduction
Inflammation and Cancer
Inflammaging in Carcinogenesis
Phytochemicals as Chemopreventive Agents
References
Chapter 6. Aging, Immunosenescence, and Cancer
Abstract
Acknowledgments
Introduction
The Definition of Aging
Aging and Cancer
Immune System and Cancer
Immunosenescence and Inflammaging
Immunosenescence and Cancer
Modulation
Conclusions
References
Chapter 7. Telomere Biology in Senescence and Aging: Focus on Cardiovascular Traits
Abstract
Acknowledgments
Introduction
Telomere Biology and Its Link to Cellular Senescence
Telomere/Telomerase and Aging
The Axis of Aging: Telomere-P53-Mitochondria
Factors Influencing Telomere Length
Factors Influencing Telomerase
Telomere Biology in Stem Cells
Telomere Biology and Cardiovascular Traits
Telomere Biology and Diabetes
Perspectives
References
Chapter 8. Epigenetics, Inflammation, and Aging
Abstract
Introduction
Epigenetics and the Fetal Origin of Adult Diseases
Mechanisms Involved in Dietary and Nutritional Modulation of DNA Methylation and Histone Modifications
Dietary Influence on Epigenetics During Early Development
Influence of Dietary Components on Epigenetic Marks in Developed Organisms
Epigenetic Changes to the Immune System that Lead to Inflammation and Disease
Conclusions
References
Chapter 9. Nutrition as an Epigenetic Modifier in Aging and Autoimmunity
Abstract
Introduction
Epigenetics and Aging
Environmental Stressors, Epigenetics, and Autoimmunity
Epigenetics in Different Autoimmune Diseases
Diet, DNA Methylation, and Immune-Mediated Diseases
Lifetime Diet
Conclusions
References
Chapter 10. Connecting Phytochemicals, Epigenetics, and Healthy Aging: Is Metabolism the Missing Link?
Abstract
Acknowledgments
Introduction
Crosstalk of Inflammation and Energy Metabolism Fuel Epigenetic Plasticity
Nutriepigenomics: Lifelong Remodeling of Our Epigenomes By Nutritional, Phytochemical, and Metabolic Factors
Xenohormetic Epigenetic Effects of Plant Secondary Metabolites Across Species: An Evolutionary Role for Stress Adaptive Responses in Healthy Aging and Longevity
Conclusion
References
Chapter 11. Diet/Nutrition, Inflammation, Cellular Senescence, Stem Cells, Diseases of Aging, and Aging
Abstract
Introduction: The Effect of Evolution of the Physical World on the Evolution of the Biological World
Evolutionary Transition from an Anoxic Environment to an Aerobic Environment: Mitochondria, Asymmetric Cell Division, Stem Cells, and Metazoans
Aging of the Organism
How the Study of Human Carcinogenesis Might Assist in Unraveling Aging: The Role of Stem Cells, Cell-Cell Communication, Diet, and Inflammation in the Multistage, Multi-Mechanism Process of Carcinogenesis
What is the Origin of the Initiated Cell?
Role of Oxygen in the Homeostatic Regulation of Stem Cells
Stem Cells, The Warburg Hypothesis, and Cancer
Roles of Nutrition/Diet and Inflammation in the Different Phases of Carcinogenesis
Stem Cells and Aging
Cellular Senescence: The End of Cellular Life Span or Only a Reversible, Transient Epigenetic Quiescent Stage of the Cell’s Life?
Summary
References
Chapter 12. Circadian Clock Mechanisms Link Aging and Inflammation
Abstract
Introduction
The Circadian System and Rhythms
Molecular Mechanisms of the Circadian Clock
Circadian Clock Disruption and Aging
Mechanisms of the Circadian Clock and Aging
Circadian Clock and Inflammation
Conclusions and Perspectives
References
Chapter 13. Obesity, Insulin Resistance, and Inflammaging
Abstract
Abbreviations
Introduction
Inflammatory Mediators, Obesity, and Aging
CrossTalk between Insulin and Inflammatory Signaling
Adipose Tissue Macrophages
Role of Other Immune Cell Types in Obesity-Associated Inflammaging
Therapeutic Options
Conclusion
References
Chapter 14. Organelle Stress and mTOR in Aging-Associated Inflammation
Abstract
Abbreviations
Introduction
Turning Cellular Stress into Inflammation: Endoplasmic Reticulum and Mitochondria
mTOR in Nutrient Sensing and Aging
mTOR Routes to Inflammation
mTOR, Inflammation, and “Hypertrophic” Aging
mTOR and Cellular Senescence
mTOR and Stem Cell Aging
mTOR, Obesity, and “Metainflammation”
Hypertrophy Versus Atrophy, mTOR, and Muscle Aging
Concluding Remarks: Aging and mTOR-Dependent Repair
References
Chapter 15. SIRT1 and Inflammaging in Chronic Obstructive Pulmonary Disease
Abstract
Acknowledgments and Disclosures
Introduction
Inflammaging in COPD
Abnormal Cellular Processes During Inflammaging in COPD
SIRT1 and Inflammaging
SIRT1 Agonists/Activators: Anti-Inflammaging Molecules
Conclusions
References
Chapter 16. Stress-Induced Premature Senescence: Another Mechanism Involved in the Process of Accelerated Aging in Chronic Obstructive Pulmonary Disease
Abstract
Introduction
Inflammaging and Cellular Senescence: Basic Characteristics
Inflammaging and Oxidative Stress in COPD
Stress-Induced Premature Senescence Under Oxidative Stress in COPD
Functions of Stress-Induced Premature Senescence Overlap with Inflammaging in COPD
COPD in a Human Model with Prematrue Aging Features Related to Inflammaging or Stress-Induced Premature Senescence
Role of Inflammaging in Extrapulmonary Manifestations of COPD
Unresolved Questions
References
Chapter 17. Cellular Senescence and Premature Aging in Lung Diseases
Abstract
Why Do Senescence- and Elderly-Specific Diseases Develop?
Cellular Senescence Associated with Aging and Illness Often Seen in Elderly People
COPD
Pulmonary Fibrosis
Differences in the Cellular Senescence Underlying the Onset of Pulmonary Emphysema and Fibrosis
Conclusions
References
Chapter 18. Rheumatoid Arthritis: Disease Pathophysiology
Abstract
Abbreviations
Introduction
T Cells in Rheumatoid Arthritis
B Cells and Autoantibodies
Cytokines in Rheumatoid Arthritis
Cartilage/Bone Destruction
Conclusions
References
Chapter 19. Aging and Anti-Aging in Hair and Hair Loss
Abstract
Introduction
Mechanisms in the Aging of Hair Follicles
Chronic Inflammation in the Pathogenesis of Hair Diseases
Anti-Aging
Conclusion
References
Chapter 20. Muscle Wasting, Dysfunction, and Inflammaging
Abstract
Introduction
Age-Related Changes in Skeletal Muscle
Disability Threshold
Causes of Age-Related Muscle Dysfunction
Exercise
Conclusion
References
Chapter 21. Matrix Metalloproteinases and Skin Inflammaging
Abstract
Introduction
Matrix Metalloproteinases and Skin-Intrinsic Aging
Matrix Metalloproteinases and Skin Photoaging
Matrix-Directed Skin Inflammaging
Concluding Remarks: Skin Inflammaging Proteases and Cutaneous Disorders in Elderly Persons
References
Chapter 22. Ocular Health, Vision, and a Healthy Diet
Abstract
Introduction
Ocular Inflammatory Diseases
Age-Related Ocular Diseases
Management of Ocular Diseases to Promote Healthy Vision
Conclusions and Perspectives
References
Chapter 23. The Role of Physical Activity in Healthy Living: Its Anti-Inflammatory Effects
Abstract
Introduction
Daily Physical Activity Recommendations
Overweight and Obesity
Type 2 Diabetes
Metabolic Syndrome
Hypertension
Hyperlipidemia
Inflammation
Review of the Evidence on the Effect of Exercise on Inflammatory Markers
References
Chapter 24. Erectile Dysfunction in Inflammaging
Abstract
Introduction
Prevalence and Etiology
Pathophysiology of Erectile Dysfunction in the Aging Man
Assessment
Treatment
Conclusions
References
Chapter 25. Role of Saturated and Polyunsaturated Fat in Obesity-Related Inflammation
Abstract
Introduction
Intracellular Fatty Acid Metabolism
Polyunsaturated Fatty Acids as Precursors of Pro- and Anti-Inflammatory Mediators
The Cellular and Molecular Basis of Inflammation
Mechanisms of Obesity-Related Low-Grade Inflammation
Role of Different Fatty Acid Types on Low-Grade Inflammation
Concluding remarks
References
Chapter 26. Cellular Stress Response, Hormesis, and Vitagens in Aging and Longevity: Role of mitochondrial “Chi”
Abstract
Acknowledgments
Introduction
Cellular Stress Response, Heat Shock Transcription Factor Biology, and the Vitagene Network
The Mitochondrial Theory of Aging
Hormesis
Conclusions and Future Directions
References
Chapter 27. Inflammaging Signaling in Health Span and Life Span Regulation: Next Generation Targets for Longevity
Abstract
Acknowledgments
Introduction
Inflammaging
Signaling Network Controlling the Aging Process
Dietary Restriction and Extension of Life Span
Potential Targets for Anti-Aging Medicine
Magic Bullets Without Potency
Conclusions
References
Chapter 28. Trophokines: Novel Therapy for Senescence-Related Fibrosis
Abstract
Introduction
Potential Clinical Applications of Trophokines
Preclinical Progress with Therapeutic Trophokines
Summary: HGF-FC/MSP-FC Fusion Provides a Possible New Therapeutic Antifibrotic Agent
References
Chapter 29. Frailty: A Basic and Clinical Challenge for the Future
Abstract
Introduction
Challenges Raised by Frailty
References
Index
- Edition: 1
- Latest edition
- Published: October 3, 2013
- Language: English
DB
Debasis Bagchi
Debasis Bagchi, PhD, MACN, CNS, MAIChE, received his Ph.D. in Medicinal Chemistry in 1982. He is a Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, TX, and Chief Scientific Officer at Cepham Research Center, Piscataway, NJ, Adjunct Faculty in Texas Southern University, Houston, TX. He served as the Senior Vice President of Research & Development of InterHealth Nutraceuticals Inc, Benicia, CA, from 1998 until Feb 2011, and then as Director of Innovation and Clinical Affairs, of Iovate Health Sciences, Oakville, ON, until June 2013. Dr. Bagchi received the Master of American College of Nutrition Award in October 2010. He is the Past Chairman of International Society of Nutraceuticals and Functional Foods (ISNFF), Past President of American College of Nutrition, Clearwater, FL, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, IL. He is serving as a Distinguished Advisor on the Japanese Institute for Health Food Standards (JIHFS), Tokyo, Japan. Dr. Bagchi is a Member of the Study Section and Peer Review Committee of the National Institutes of Health (NIH), Bethesda, MD. He has published 321 papers in peer reviewed journals, 30 books, and 18 patents. Dr. Bagchi is also a Member of the Society of Toxicology, Member of the New York Academy of Sciences, Fellow of the Nutrition Research Academy, and Member of the TCE stakeholder Committee of the Wright Patterson Air Force Base, OH. He is also Associate Editor for the Journal of Functional Foods, Journal of the American College of Nutrition, and the Archives of Medical and Biomedical Research, and is also serving as Editorial Board Member of numerous peer reviewed journals, including Antioxidants & Redox Signaling, Cancer Letters, Toxicology Mechanisms and Methods, and The Original Internist, among others.
Affiliations and expertise
Professor, Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, USA; Chief Scientific Officer, Cepham Research Center, Piscataway, New Jersey; Adjunct Faculty, Texas Southern University, Houston, Texas, USARead Inflammation, Advancing Age and Nutrition on ScienceDirect