Industrial Process Scale-up
A Practical Innovation Guide from Idea to Commercial Implementation
- 3rd Edition - April 1, 2027
- Latest edition
- Author: Jan Harmsen
- Language: English
Industrial Product and Process Scale-up: A Practical Innovation Guide from Idea to Commercial Implementation, Third Edition serves as a comprehensive guide for all aspects of pr… Read more
End of Summer Sale
Save up to 30% off
Bright savings for research, study, and discovery
Description
Description
Industrial Product and Process Scale-up: A Practical Innovation Guide from Idea to Commercial Implementation, Third Edition serves as a comprehensive guide for all aspects of process and product scale-up from idea generation, through R&D, engineering, procurement, construction to implementation, providing insights on identifying and mitigating risks associated with commercial scale implementation - providing insights on identifying and mitigating risks associated with commercial scale implementation. The Third Edition introduces new strategies for product scale-up and integrating product and process scale-up across six innovation stages, offering methods for pilot plant decision-making, scale-down processes, and evaluation criteria for demo-plant versus commercial scale plant selection. Special emphasis is placed on unit operation scale-up methods and intensified process steps to aid decision-making during the feasibility stage, benefiting industries like pharma and active pharma ingredients. This book will be a valuable guide to researchers in industry, working to scale-up products and processes across commercial sectors. This book will also be a very useful guide to late-stage students and academics working in industrial chemical process engineering.
Key features
Key features
- Describes successful and failed industrial cases and their analysis, including real-world examples
- Offers easily accessible, step-by-step and concise guidelines for industrial process scale-up
- Based on industrial experiences and practices that reduce the risks of commercial scale implementation of new processes to acceptable levels and reduce cost and time of process innovation
- Explains each stage of the innovation funnel, from research, development, demonstration and commercial implementation for any process type and branch
- Provides heuristics to decide for a down-scaled pilot plant
- Offers complete methodology for six unit operations scale-up methods to select from, including case studies
Readership
Readership
Academics and students at graduate level and above working in chemical process engineering - Industrial practitioners working in process and product research, development and design
Table of contents
Table of contents
1. Introduction
1.1 book purpose and set-up
1.2 Definition scale-up
1.3 Product and process industries
1.4 Innovation stage-gate model
1.5 Partners and stakeholders for innovation
2. Discovery stage
2.1 purpose
2.2 Ideas generation
2.3 Product design
2.4 Process Design
2.4.1 Unit Operation based Process design
2.4.2 Process Intensified Unit Operation based Process design
2.4.3 Function integration based Process design
2.5 Modelling
2.6 Experimental
2.6.1 basic data generation
2.6.2 Product testing
2.6.3 Process testing
2.7 Assessment
2.8 Stage-gate evaluation
2.9 Pitfalls
2.10 Industrial cases
2.11 Exercises
3. Concept stage
3.1 purpose
3.2 Ideas generation
3.3 Product design
3.4 Process Design
3.4.1 Unit Operation based Process design
3.4.2 Process Intensified Unit Operation based Process design
3.4.3 Function integration based Process design
3.5 Modelling
3.6 Experimental
3.6.1 basic data generation
3.6.2 Product testing
3.6.3 Process testing
3.7 Assessment
3.8 Stage-gate evaluation
3.9 Pitfalls
3.10 Industrial cases
3.11 Exercises
4. Feasibility stage
4.1 purpose
4.2 Ideas generation
4.3 Product design
4.4 Process Design
4.4.1 Unit Operation based Process design
4.4.2 Process Intensified Unit Operation based Process design
4.4.3 Function integration based Process design
4.5 Modelling
4.6 Experimental
4.6.1 basic data generation
4.6.2 Product testing
4.6.3 Process testing
4.7 Assessment
4.8 Stage-gate evaluation
4.9 Pitfalls
4.10 Industrial cases
4.11 Exercises
5. Development stage
5.1 purpose
5.2 Ideas generation
5.3 Product design
5.4 Process Design
5.4.1 Unit Operation based Process design
5.4.2 Process Intensified Unit Operation based Process design
5.4.3 Function integration based Process design
5.5 Modelling
5.6 Experimental
5.6.1 basic data generation
5.6.2 Product testing
5.6.3 Process testing
5.7 Assessment
5.8 Stage-gate evaluation
5.9 Pitfalls
5.10 Industrial cases
5.11 Exercises
6. Engineering Procurement Construction stage
6.1 Purpose
6.2 Demonstration plant decision
6.2.1. Product market introduction
6.2.2 Demonstration plant decision
6.3 Engineering design
6.3.1 Modular design
6.4 Procurement
6.5 Construction
6.5.1 Prefabrication
6.5.2 Stick-built construction at production site
6.6 Pitfalls
6.7 Industrial case
6.8 Exercises
7. Commercial scale implementation
7.1 Process commissioning and start-up
7.2 Product market implementation
7.3 Pitfalls
7.4 Exercises
1.1 book purpose and set-up
1.2 Definition scale-up
1.3 Product and process industries
1.4 Innovation stage-gate model
1.5 Partners and stakeholders for innovation
2. Discovery stage
2.1 purpose
2.2 Ideas generation
2.3 Product design
2.4 Process Design
2.4.1 Unit Operation based Process design
2.4.2 Process Intensified Unit Operation based Process design
2.4.3 Function integration based Process design
2.5 Modelling
2.6 Experimental
2.6.1 basic data generation
2.6.2 Product testing
2.6.3 Process testing
2.7 Assessment
2.8 Stage-gate evaluation
2.9 Pitfalls
2.10 Industrial cases
2.11 Exercises
3. Concept stage
3.1 purpose
3.2 Ideas generation
3.3 Product design
3.4 Process Design
3.4.1 Unit Operation based Process design
3.4.2 Process Intensified Unit Operation based Process design
3.4.3 Function integration based Process design
3.5 Modelling
3.6 Experimental
3.6.1 basic data generation
3.6.2 Product testing
3.6.3 Process testing
3.7 Assessment
3.8 Stage-gate evaluation
3.9 Pitfalls
3.10 Industrial cases
3.11 Exercises
4. Feasibility stage
4.1 purpose
4.2 Ideas generation
4.3 Product design
4.4 Process Design
4.4.1 Unit Operation based Process design
4.4.2 Process Intensified Unit Operation based Process design
4.4.3 Function integration based Process design
4.5 Modelling
4.6 Experimental
4.6.1 basic data generation
4.6.2 Product testing
4.6.3 Process testing
4.7 Assessment
4.8 Stage-gate evaluation
4.9 Pitfalls
4.10 Industrial cases
4.11 Exercises
5. Development stage
5.1 purpose
5.2 Ideas generation
5.3 Product design
5.4 Process Design
5.4.1 Unit Operation based Process design
5.4.2 Process Intensified Unit Operation based Process design
5.4.3 Function integration based Process design
5.5 Modelling
5.6 Experimental
5.6.1 basic data generation
5.6.2 Product testing
5.6.3 Process testing
5.7 Assessment
5.8 Stage-gate evaluation
5.9 Pitfalls
5.10 Industrial cases
5.11 Exercises
6. Engineering Procurement Construction stage
6.1 Purpose
6.2 Demonstration plant decision
6.2.1. Product market introduction
6.2.2 Demonstration plant decision
6.3 Engineering design
6.3.1 Modular design
6.4 Procurement
6.5 Construction
6.5.1 Prefabrication
6.5.2 Stick-built construction at production site
6.6 Pitfalls
6.7 Industrial case
6.8 Exercises
7. Commercial scale implementation
7.1 Process commissioning and start-up
7.2 Product market implementation
7.3 Pitfalls
7.4 Exercises
Product details
Product details
- Edition: 3
- Latest edition
- Published: April 1, 2027
- Language: English
About the author
About the author
JH
Jan Harmsen
Dr. Jan Harmsen is currently consultant of Harmsen Consultancy B.V. From 1996 to 2010 he was Principal Process Developer, Shell Technology Center Amsterdam. After thirty-three years of industrial experience in exploratory research, development, process design, and chemicals manufacturing, ir. Harmsen now successfully works as an independent consultant on innovation with sustainable development in view. He has published three books with Elsevier.
Affiliations and expertise
Consultant, Harmsen Consultancy B.V., Amsterdam, The Netherlands