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Elsevier

Indole Alkaloids

Spirooxindole

  • 1st Edition - January 30, 2022
  • Latest edition
  • Authors: Maliha Uroos, Abdul Hameed, Sadia Naz, Muhammad Raza Shah
  • Language: English

Indole Alkaloids: Spirooxindole details the multistep synthesis of natural products using schematic diagrams, providing a quick-and-easy way to review and understand new and novel… Read more

Description

Indole Alkaloids: Spirooxindole details the multistep synthesis of natural products using schematic diagrams, providing a quick-and-easy way to review and understand new and novel synthetic strategies to construct structural frameworks of natural products. As a volume in the Visual Guides to Natural Product Synthesis series, this book presents the schematic total syntheses of natural products containing a “spirooxindole” core structure. It covers spirooxindole molecules through visual diagrams, highlighting key steps involved in total, formal and semi-syntheses. Sections cover Brevianamide A and B, Citrinadin A and B, Coerulescine and Horsfiline, Elacomine and Isoelacomine, Gelsemine, Paraherquamide A and B, Rynchophylline, Isorynchophylline, and more.

Visual layouts provide quick-and- easy access to developed synthetic routes towards the targeted spirooxindoles.

Key features

  • Outlines synthetic strategies for natural products bearing a spirooxindole core structure
  • Includes schematic diagrams of multistep synthetic routes, highlighting key steps along the way
  • Describes all routes for the formal synthesis, semi-synthesis and total synthesis of spirooxindole alkaloids

Readership

Researchers working in the area of organic synthesis and natural products, especially those who are involved in the development of new, efficient and novel methodologies for natural product synthesis

Table of contents

1. Indole alkaloids; Spirooxindoles

2. Brevianamide A and B

3. Citrinadin A and B

4. Coerulescine and Horsfiline

5. (±)-Elacomine and (±)-Isoelacomine

6. Gelsemine

7. Paraherquamide A and B

8. Rynchophylline and Isorynchophylline

9. Spirotryprostatin A

10. (‒)-Spirotryprostatin B

11. Strychnofoline

Product details

  • Edition: 1
  • Latest edition
  • Published: February 4, 2022
  • Language: English

About the authors

MU

Maliha Uroos

Dr. Maliha Uroos completed her PhD in synthetic organic chemistry in 2012 from the University of Nottingham under HEC Faculty Development Scholarship. She was awarded EPSRC post-doctoral fellowship (2012-13) at the University of Nottingham, UK. She was appointed Lecturer at University of the Punjab in 2007 and currently working as Associate Professor (2020 to date) and Director, Centre for Research Ionic Liquid, School of Chemistry, University of the Punjab. Her main focus is synthetic organic chemistry and research interests include synthesis and applications of ionic liquids, synthesis of biologically active molecules, sustainable energy production and development of green processes for setting up bio-refinery from agricultural waste.
Affiliations and expertise
Associate Professor and Director, Centre for Research Ionic Liquid, School of Chemistry, University of the Punjab, Pakistan

AH

Abdul Hameed

Dr. Abdul Hameed Dr. Abdul Hameed completed his PhD in Organic Chemistry from The University of Nottingham, UK. He worked in the area of natural products synthesis. He was a post-doc fellow in Max-Planck Institut für Polymerforschung, Germany in synthetic division headed by Prof. Dr. Klaus Müllen. There he worked on the functionalization of adenylyl cyclsase inhibitors via chemical methods to conjugate them with monoclonal antibody to study their biological potential in Regulatory T cells (Treg). His current research interests are including the development of novel methodologies, their utilization in natural products synthesis, the synthesis heterocyclic compound compounds to evaluate their biological potential.
Affiliations and expertise
Department of Chemistry, University of Sahiwal, Sahiwal 57000, Pakistan

SN

Sadia Naz

Sadia Naz is currently a PhD student at Centre for Research Ionic Liquid, School of Chemistry, University of the Punjab (2018 to onwards) and is working as research assistant in HEC NRPU project with Dr. Maliha Uroos (2019 to onwards). She has publications in international journals and presented her work in various international and national conferences. Her research interests include synthetic organic chemistry, ionic liquids, conversion of agricultural waste materials into valuable platform chemicals.
Affiliations and expertise
Centre for Research Ionic Liquid, School of Chemistry, University of the Punjab, Pakistan

MS

Muhammad Raza Shah

Prof. Muhammad Raza Shah is a professor and Director of the International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Pakistan. He holds four US patents. Dr. Shah has received numerous awards, including the Khwarizmi International Award from the Ministry of Science, Research and Technology, Iran (2023). He has also been honored with the Civil Award Tamgha-i-Imtiaz (2015), Dr. Raziuddin Prize (2015), Prof. Atta-ur-Rahman Gold Medal by the Pakistan Academy of Sciences, Avicenna Science & Innovation Award (2015) by Brain Trust UK, and the Abdus Salam Award in Chemistry (2006). He was named TWAS Young Affiliate in 2010 by The World Academy of Sciences. Prof. Shah is a Fellow of the International Union of Pure and Applied Chemistry, the Chemical Society of Pakistan, the Islamic World Academy of Sciences, and the Royal College of Physicians (Edinburgh). Dr. Shah has conducted 29 Phase-I (BE and PK) studies, 04 Phase-II Randomized Clinical Trial as PI and lead the Phase-I RCT of Sinopharm COVID-19 vaccine and Phase-III RCT of COVID-19 booster vaccine as country PI.
Affiliations and expertise
Professor, International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University, Karachi, Pakistan

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