Inborn Errors of Immunity
A Practical Guide
- 1st Edition - January 29, 2021
- Editors: Asghar Aghamohammadi, Hassan Abolhassani, Nima Rezaei, Reza Yazdani
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 0 2 8 - 4
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 3 1 8 9 - 0
Awareness among clinicians about PIDs, which consist of more than 400 different entities, plays an important role in ensuring that patients receive a timely diagnosis. Fu… Read more
Awareness among clinicians about PIDs, which consist of more than 400 different entities, plays an important role in ensuring that patients receive a timely diagnosis. Furthermore, clinicians who are educated about PIDs can give their patients access to optimal management of their condition, thus helping the patient achieve a better quality-of-life and long-term prognosis.
Inborn Errors of Immunity: A Practical Guide provides the most up-to-date information for busy students, nurses, clinical residents, practicing physicians, and even basic researchers. Readers will benefit from a well-structured breakdown of complicated PID diseases, including approaches to their clinical signs/symptoms and immunologic/laboratory findings.
- Presents valuable contribution of more than 40 expert chapter authors, from top centers spanning five continents, each in a specific PID field
- Covers various aspects of PID using updated clinical guidelines and standard stepwise pipelines
- Focuses on the latest developments in the molecular diagnosis and pathogenesis of diseases, with easy explanation and schematic representation of defective signaling pathways
- Includes dedicated sections for clinical features and immunological tests with carefully-curated figures of PID manifestations, imaging, and histological/pathological illustrations to create the first PID medial-color atlas
- Summarizes the updated conventional and specific treatments and follow-up notes for different PID diseases
General practitioners, hospital clinicians; specialists including pediatricians, infectious disease specialists, allergy and immunology specialists, and rheumatologists
1. Introduction
2. Immunodeficiencies affecting cellular and humoral immunity
3. Combined immunodeficiencies with associated or syndromic features
4. Predominantly Antibody Deficiencies (PADs)
5. Diseases of immune dysregulation
6. Phagocyte defects
7. Defects in Intrinsic and Innate immunity
8. Auto-inflammatory disorders
9. Complement deficiencies
10. Phenocopies of PID
11. Treatment and Management
- Edition: 1
- Published: January 29, 2021
- Language: English
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Asghar Aghamohammadi
Asghar Aghamohammadi was a Professor in Pediatrics and Clinical Immunology, at the Tehran University of Medical Sciences (TUMS) in Iran. He directed the Research Center for Immunodeficiencies (RCID), the pre-eminent centre in Iran for primary immunodeficiency. He completed a fellowship in Great Ormond Street Hospital, UK and earned a PhD from the University of Toyama, Japan. His work focused on primary immunodeficiency, including primary antibody deficiency disorders, molecular diagnosis, and patient treatment and management. His work has been widely published and referred to in his field.
Affiliations and expertise
Professor, Department of Pediatrics; President, RCID, Pediatrics Center of Excellence, Children's Medical Center, TUMS, IranHA
Hassan Abolhassani
Hassan Abolhassani is a leading member of the Junior Faculty at the Karolinska Institute (KI) and a team leader at Division of Clinical Immunology in the Department of Laboratory Medicine, KI in Sweden. He received his MD and his first PhD in Immunogenetics from TUMS and his second PhD in Clinical Immunology from the KI. His work focuses on the gene discovery and pathogenesis of primary antibody deficiency and the immune pathways involved, to help physicians and immunologists understand immune-related genes with unknown functions. He has received numerous academic awards and is widely published in the field.
Affiliations and expertise
Team leader, Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, SwedenNR
Nima Rezaei
Professor Nima Rezaei gained his medical degree (MD) from Tehran University of Medical Sciences and subsequently obtained an MSc in Molecular and Genetic Medicine and a PhD in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also spent a short-term fellowship of Pediatric Clinical Immunology and Bone Marrow Transplantation in the Newcastle General Hospital. Professor Rezaei is now the Full Professor of Immunology and Vice Dean of Research, School of Medicine, Tehran University of Medical Sciences, and the co-founder and Head of the Research Center for Immunodeficiencies. He is also the founding President of the Universal Scientific Education and Research Network (USERN). Professor Rezaei has already been the Director of more than 55 research projects and has designed and participated in several international collaborative projects. Professor Rezaei is an editorial assistant or board member for more than 30 international journals. He has edited more than 35 international books, has presented more than 500 lectures/posters in congresses/meetings, and has published more than 1,000 scientific papers in the international journals.
Affiliations and expertise
Professor, Department of Immunology, School of Medicine; Head, Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences; Founding President, Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA),Universal Scientific Education and Research Network (USERN),Tehran, IranRY
Reza Yazdani
Reza Yazdani, PhD, is an Assistant Professor and Vice President of the Research Center for Immunodeficiencies (RCID) at Tehran University of Medical Sciences, the leading institution for the study of inborn errors of immunity (IEI) in Iran. He earned his PhD in Medical Immunology from Isfahan University of Medical Sciences, Iran, and completed a postdoctoral fellowship at Thomas Jefferson University, USA. His research focuses on the pathogenesis and diagnosis of IEIs, with particular expertise in the application of flow cytometry. He has received numerous awards and honors and has published over 160 scientific papers in international journals. He is honored as the top 1% of highly cited scientific researchers in the field of Immunology, Essential Science Indicators (ESI, Web of Science). He was selected as the Best Young Researcher in Medical Sciences at the Avicenna Festival 2025. He also serves on the editorial boards of several international journals.
Affiliations and expertise
Assistant Professor and Vice President of Research Center for Immunodeficiencies (RCID) at Tehran University of Medical SciencesRead Inborn Errors of Immunity on ScienceDirect