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Immunomodulatory Effects of Nanomaterials
Assessment and Analysis
- 1st Edition - June 2, 2022
- Editor: Mahmoud Elsabahy
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 0 6 0 4 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 0 8 2 4 - 5
Immunomodulatory Effects of Nanomaterials: Assessment and Analysis provides an overview of the modulatory impact of nanomaterials on the immune system, as well as evaluativ… Read more
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Request a sales quoteImmunomodulatory Effects of Nanomaterials: Assessment and Analysis provides an overview of the modulatory impact of nanomaterials on the immune system, as well as evaluative and analytical methods for assessing effects. Sections cover a range of common nanomaterials for biomedical use and how different properties can elicit varied responses from the immune system. The immunomodulatory effects of these materials are then discussed, with coverage on adverse and/or toxic effects on the immune system, as well as desired modulatory effects to improve efficacy of applied therapeutics. Readers will also learn about the best evaluation methods for immunomodulatory effects of nanomaterials and associated risks.
This book is a useful reference for academics and researchers with an interest in immunology, but it is also idea for those working in the fields of materials science, biomedical engineering, pharmaceutical science, immunology and toxicology.
- Details a range of common nanomaterials and how their specific properties and characteristics interact with the immune system
- Discusses the immunomodulatory effects of nanomaterials, from unintentional and potentially harmful, to intentional and desired effects on the immune system
- Explores methods for evaluation of immunomodulatory effects of nanomaterials, as well as precautions and risks for data analysis and interpretation
Academics and researchers in materials science, engineering, pharmaceutical science. Toxicologists and immunologists
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- About the editor
- Preface
- Acknowledgments
- Introduction
- Chapter 1. Nanomaterials: classification, composition, and recent advances in synthesis
- Abstract
- 1.1 Introduction to nanotechnology
- 1.2 Terminology of nanotechnology
- 1.3 Unique properties of nanomaterials
- 1.4 Classification of nanomaterials
- 1.5 Nanomaterial synthesis
- 1.6 Characterization of nanomaterials
- 1.7 Concluding remarks and future avenue
- References
- Chapter 2. Applications of nanoengineered therapeutics and vaccines: special emphasis on COVID-19
- Abstract
- 2.1 Coronavirus disease-2019
- 2.2 Morphological structure and genome
- 2.3 Clinical presentation, radiological features, and laboratory investigations
- 2.4 Therapeutic attempts
- 2.5 Antiviral therapy
- 2.6 Lopinavir/ritonavir and Arbidol
- 2.7 Immune therapy
- 2.8 Tocilizumab
- 2.9 Bamlanivimab (LY3819253 or LY-CoV555) and Etesevimab (LY3832479 or LY-CoV016)
- 2.10 Casirivimab (previously REGN10933) and imdevimab (previously REGN10987)
- 2.11 JAK inhibitors
- 2.12 Baricitinib
- 2.13 Ruxolitinib
- 2.14 Jakotinib
- 2.15 Vaccines
- 2.16 Nanoengineered therapeutics and vaccines in development for management of COVID-19
- 2.17 Current status and perspectives
- Acknowledgment
- References
- Chapter 3. Nanomaterials and immune system
- Abstract
- 3.1 Introduction
- 3.2 The immune system
- 3.3 Nanomaterials
- 3.4 Cytokines as biomarkers of immunomodulatory properties of nanomaterials
- 3.5 Mechanisms of nanoparticle immunotoxicity
- 3.6 Relationship between cytokines and adverse reactions
- 3.7 Evaluation of nanoparticle immunotoxicity
- 3.8 Controlling the immunotoxicity of nanomaterials
- 3.9 Conclusions
- References
- Chapter 4. Methods for evaluation of the immunomodulatory effects of nanoparticles
- Abstract
- 4.1 Introduction
- 4.2 Multiplexing technique for evaluation of particulate materials
- 4.3 Preassessment step: optional
- 4.4 Data mining and analysis
- References
- Chapter 5. Recommendations and use of multiplex biomarker assays
- Abstract
- 5.1 Introduction
- 5.2 Conclusions
- References
- Chapter 6. Precautions during evaluation of immunotoxicity of particulate materials
- Abstract
- References
- Chapter 7. Data analysis and interpretation
- Abstract
- 7.1 Discussion
- 7.2 Method
- References
- Index
- No. of pages: 194
- Language: English
- Edition: 1
- Published: June 2, 2022
- Imprint: Woodhead Publishing
- Paperback ISBN: 9780323906043
- eBook ISBN: 9780323908245
ME
Mahmoud Elsabahy
Prof Mahmoud Elsabahy is a professor of pharmaceutical technology and nanomedicine with more than 15 years of experience in the development of cutting-edge technologies for gene therapy and biomedical delivery applications. He is currently a visiting scholar at the Texas A&M University, Texas, United States; vice dean of the School of Biotechnology and head of Science Academy, Badr University in Cairo (BUC), Cairo, Egypt; and a professor at the Faculty of Pharmacy, Assiut University, Assiut, Egypt. From 2011 to 2020, he was the assistant director of the Laboratory for Synthetic-Biologic Interactions at Texas A&M University. He has previously contributed to four books on nanomedicine and nanomaterials for biomedical applications. Prof Elsabahy completed M.Sc. and PhD degrees from the Faculty of Pharmacy, University of Montreal “Pharmaceutical Technology” (Montreal, Canada). He has contributed to c. 90 top peer-reviewed publications, which mainly focused on furthering the use of nanotechnology in the targeted delivery of therapeutic and diagnostic agents, for which he has received several national and international prestigious awards.
Affiliations and expertise
Visiting Professor, Texas A&M University, College Station, TX, USA; Director, Badr University, Cairo (BUC) Science Academy, Cairo, Egypt; Associate Professor, Faculty of Pharmacy, Assiut University, Assiut, Egypt