Immunomodulation in Domestic Food Animals

Contributors

Foreword

Preface

Part I: Introduction

Rationale for Using Immunopotentiators in Domestic Food Animals

I. Introduction

II. Why Are Immunomodulators Needed?

ΙII. Specific versus Nonspecific Immunomodulation

IV. Summary

References

Model Systems to Study Immunomodulation in Domestic Food Animals

I. Introduction

II. Stress Models

III. Glucocorticoid Immunosuppression Models

IV. Infectious Disease Model Systems

V. Summary

References

Mechanisms of Action of Some Immunomodulators Used in Veterinary Medicine

I. Introduction

II. Structure and Function of the Immune System

III. Immunomodulation

IV. Physiologically Important Immunomodulators

V. Synthetic Compounds with Immunomodulatory Activity

VI. Microbial Products as Immunomodulators

VII. Liposomes

VIII. Concluding Comments

References

Part II: Chemical Immunomodulation

Chemically Induced Immunomodulation in Domestic Food Animals

I. Introduction

II. Chemin Immunomodulation in Domestic Food Animal Species

ΙII. Chemical Immunomodulators Which Have Apparently Not Been Evaluated in Domestic Food Animals

IV. Summary

References

Classical and New Approaches to Adjuvant Use in Domestic Food Animals

I. Introduction

II. Aluminum Salts

ΙII. Oil Emulsions

IV. Surface Active Agents

V. ISCOMS

VI. Muramyldipeptides

VII. Polymeric Adjuvants

VIII. General Conclusions

References

A Thymosin-Tuftsin Conjugate as a New Potential Immunomodulator in Cattle

I. Introduction

II. Tuftsin: A Macrophage Activator

ΙII. Thymosin-α: A Τ Cell Activator

IV. Thymosin-Tuftsin Conjugate (IMP-1)

V. Conclusion

References

Part III: Cytokine Immunomodulation

The Molecular Biology of Large Animal Cytokines

I. Cytokine Biology

II. Recombinant Bovine and Porcine Cytokines

ΙII. Conclusions

References

Interferon Immunomodulation in Domestic Food Animals

I. Introduction

II. Modulation of Nonspecific Antimicrobial Defense Mechanisms

ΙII. Modulation of the Specific Cellular Immune Response

IV. Enhancement of Antimicrobial Mechanisms in the Gut

V. Immunoenhancement in Noninfectious Diseases

VI. Concluding Remarks

References

In Vivo Use of Interleukins in Domestic Food Animals

I. Introduction

II. Rationale for Using Interleukins in Domestic Food Animals

ΙII. In Vivo Studies with Interleukins in Domestic Food Animals

IV. Conclusions and Prospects

References

Part IV: Physiologically Regulated Immunomodulation

Nutritional Modulation of Immunity in Domestic Food Animals

I. Introduction

II. Protein and Energy

ΙII. Fat-Soluble Vitamins

IV. Water-Soluble Vitamins

V. Minerals

VI. Conclusion

References

Neuroendocrine-Immune Interactions

I. Introduction

II. Characteristics of the Neuroendocrine-Immune System

ΙII. Conclusions

References

Potential for Improving Animal Health by Modulation of Behavior and Immune Function

I. Introduction

II. Behavior of Farm Animals

ΙII. Social Behavior and Immune Function

IV. Nonsocial Behaviors and Immune Function

V. Brain-Immune Interactions

VI. Concluding Remarks

References

Index