Immunology
With STUDENT CONSULT Online Access
- 8th Edition - August 27, 2012
- Editors: David Male, Jonathan Brostoff, David Roth, Ivan Roitt
- Language: English
- eBook ISBN:9 7 8 - 0 - 7 0 2 0 - 5 6 6 6 - 6
- eBook ISBN:9 7 8 - 0 - 7 0 2 0 - 5 0 2 8 - 2
Immunology, 8th Edition makes it easy for you to learn all the basic and clinical concepts you need to know for your courses and USMLEs. This medical textbook’s highly visua… Read more
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Immunology, 8th Edition makes it easy for you to learn all the basic and clinical concepts you need to know for your courses and USMLEs. This medical textbook’s highly visual, carefully structured approach makes immunology simple to understand and remember.
- Understand the building blocks of the immune system - cells, organs and major receptor molecules - as well as initiation and actions of the immune response, especially in a clinical context.
- Visually grasp and retain difficult concepts easily thanks to a user-friendly color-coded format, key concept boxes, explanatory diagrams, and over 190 photos to help you visualize tissues and diseases.
- Put concepts into practice. " Critical Thinking Boxes" and 25 online cases encourage you to "think immunologically" while anchoring your understanding of immunology through clinical application.
- Gauge your mastery of the material and build confidence with high-yield style chapter-opening summaries and case-based and USMLE-style questions that provide effective chapter review and quick practice for your exams.
- Access the full contents online at www.studentconsult.com where you'll find the complete text and illustrations, USMLE-style questions, clinical cases, and much more!
Preface vii
List of Contributors ix
SECTION 1
Components of the Immune System 1
1 Introduction to the Immune System 3
David Male
2 Cells, Tissues, and Organs of the
Immune System 17
Peter M Lydyard and Nino Porakishvili
3 Antibodies 51
Roy Jefferis
4 Complement 71
B Paul Morgan
5 T Cell Receptors and MHC Molecules 89
David B Roth
SECTION 2
Modes of Immune Response 107
6 Mechanisms of Innate Immunity 109
David Male
7 Mononuclear Phagocytes in Immune
Defense 125
Luisa Martinez-Pomares and
Siamon Gordon
8 Antigen Presentation 143
David Male
9 Cell Cooperation in the Antibody
Response 157
Joseph C Marini and Kalpit A Vora
10 Cell-mediated Cytotoxicity 171
Victoria Male
11 Regulation of the Immune Response 183
David Bending
12 Immune Responses in Tissues 199
David Male
SECTION 3
Defense Against Infectious Agents 209
13 Immunity to Viruses 211
Persephone Borrow and Anthony A Nash
14 Immunity to Bacteria and Fungi 223
Gregory J Bancroft
15 Immunity to Protozoa and Worms 243
Richard J Pleass
16 Primary Immunodeficiencies 263
Luigi D Notarangelo
17 AIDS, Secondary Immunodeficiency
and Immunosuppression 277
Dean H Kedes and Lisa A Nichols
18 Vaccination 289
Colin Casimir
SECTION 4
Immune Responses Against Tissues 305
19 Immunological Tolerance 307
Thomas Kamradt
20 Autoimmunity and Autoimmune
Disease 323
James E Peters and David A Isenberg
21 Transplantation and Rejection 341
Andrew J T George
22 Immunity to Cancers 355
Pramod K Srivastava
V
SECTION 5
Hypersensitivity 369
23 Immediate Hypersensitivity (Type I) 371
Thomas A E Platts-Mills
24 Hypersensitivity (Type II) 393
David Male
25 Hypersensitivity (Type III) 405
David P D’Cruz
26 Hypersensitivity (Type IV) 419
Warwick J Britton
Appendices online
1. Major Histocompatibility Complex
2. CD System
3. The Major Cytokines
4. Human Chemokines and Their Receptors
Critical thinking: Explanations 433
Glossary 445
Index 455
vi
Contents
- Edition: 8
- Published: August 27, 2012
- Language: English
DM
David Male
David Male is Professor of Biology in the Department of Life Sciences at The Open University, Milton Keynes.
Affiliations and expertise
Professor of Biology, Department of Life Sciences, The Open University, Milton Keynes, UKJB
Jonathan Brostoff
Affiliations and expertise
Professor Emeritus of Allergy and Environmental Health, King's College London, London, UKDR
David Roth
Affiliations and expertise
Simon Flexner Professor and Chair of Pathology and Laboratory Medicine, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USAIR
Ivan Roitt
Affiliations and expertise
Hon Director, Middlesex Centre for Investigative & Diagnostic Oncology, School of Health & Social Sciences, Middlesex University, London, UK