Immunology, Inflammation and Diseases of the Eye
- 1st Edition - August 19, 2016
- Editors: Darlene A. Dartt, Reza Dana, Patricia D’Amore, Jerry Niederkorn
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 3 8 1 9 7 4 - 1
- Paperback ISBN:9 7 8 - 0 - 0 8 - 1 0 1 6 5 9 - 6
- eBook ISBN:9 7 8 - 0 - 1 2 - 3 8 1 9 7 5 - 8
This selection of articles from the Encyclopedia of the Eye provides a comprehensive overview of immunological features, diseases and inflammation of the eye and its support s… Read more
This selection of articles from the Encyclopedia of the Eye provides a comprehensive overview of immunological features, diseases and inflammation of the eye and its support structures and organs. Rather than taking an immunological focus that is strictly suitable for clinicians, the volume offers a considerable basic science background and addresses a broad range of topics - the immune system of the eye, its various disorders, mechanisms of inflammation of the eye and visual system, treatment, wound healing mechanisms, stem cells, and more.
- The first single volume to integrate comparative studies into a comprehensive resource on the neuroscience of ocular immunology
- Chapters are carefully selected from the Encyclopedia of the Eye by the world's leading vision researchers
- The best researchers in the field provide their conclusions in the context of the latest experimental results
Students, researchers and practitioners in ophthalmology and optometry, neuroscience, immunology, physiology, cell biology, pharmacology, and related disciplines
I. Regulation of the Immune Response of the Eye and Its Dysregulation in Inflammation and Infection
Adaptive Immune System and the Eye: Mucosal Immunity
Adaptive immune system and the eye: T-cell mediated immunity
Innate immune system and the eye
Defense mechanisms of tears and ocular surface
Role of complement in the ocular immune response
Immunoregulatory processes that sustain immune privilege in the eye
Immunosupressive and anti-inflammatory molecules that maintain immune previlege of the eye
Antigen-presenting cells in the eye and ocular surface
Regenfus and Cursiefen- Angiogenesis in the eye
Dry eye: An immune-based inflammation
Penetrating keratoplasty
Corneal epithelium- response to infection
Immunopathogenesis of HSV Keratitis
Immunopathogenesis of Onchocerciasis (River Blindness)
Immunopathogenesis of pseudomonas keratitis
Immunobiology of acanthomeba karatitis
Pathogenesis of fungal keratitis
Molecular and cellular mechanisms in allergic conjunctivitis
Conjunctiva Immune surveillance
Inflammation of the Conjunctiva
Immunopathogenesis of experimental uveitic diseases
Pathogenesis of Uveitis in humans
Immunobiology of uveal melanoma
Immunobiology of age-related macular degeneration
Pathogenesis and Immunology of Bacterial endophthalmitis
II. Angiogenesis in the Eye and Its Dysfunction in the Retina, Cornea and Vitreous
Orbiatl vascular anatomy
Developmental anatomy of retinal and choroidal vasculature
Development of the retinal vasculature
Physiological Anatomy of the retinal vasculature
Physiological anatomy of the choroidal vasculature
Properties and functions of the vessels of the ciliary body
Anatomy and regulation of the optic nerve blood flow
Angiogenesis in response to hypoxia
Angiogenesis and inflammation
Angiogenesis in wound healing
Hemangiogenesis versus lymphangiogenesis
Innate immunity and angiogenesis
Mechanisms of Angiostasis
Stability and functional integrity of new blood vessels
Vessel regression
Blood-retinal barrier
Breakdown of the blood-retinal barrier
Retinal pigment epithelium barrier
Breakdown of the retinal pigement epithelium blood-retinal barrier
Retinal pigment epithelial-choroid interactions
Macular edema
Central vein occlusion
Pathological retinal angiogenesis
Proliferative vitreoretinopathy
Choroidal neovascularization
The vascular stem cell
Concept of Angiogenic Privilege
Corneal angiogenesis
Avascularity of the cornea
Anti-angiogenic properties of vitreous
- Edition: 1
- Published: August 19, 2016
- Language: English
DD
Darlene A. Dartt
Affiliations and expertise
Senior Scientist, Schepens Eye Research Institute, Harvard Medical SchoolRD
Reza Dana
In addition to his role as Senior Scientist and Co-Director at the Schepens Eye Research Institute, Dr. Reza Dana holds the Claes H. Dohlman Chair in Ophthalmology at Harvard Medical School. He is Director of the Cornea & Refractive Surgery Service at the Massachusetts Eye & Ear, and serves as the Vice Chairman of the Harvard Department of Ophthalmology and Associate Chief of Ophthalmology for Academic Programs at Massachusetts Eye and Ear. After graduating Summa Cum Laude from St. Paul’s School in New Hampshire, he completed his bachelor’s (Phi Beta Kappa), graduate, and medical education at Johns Hopkins University. He performed his residency in Ophthalmology at the Illinois Eye and Ear Infirmary in Chicago, followed by a clinical fellowship in Cornea and External Diseases at the Wills Eye Hospital in Philadelphia. Reza then completed additional fellowship training in Immunology and Uveitis at the Massachusetts Eye and Ear Infirmary, and in Ocular and Transplantation Immunology at the Schepens Eye Research Institute. Dr. Dana also holds a Master of Science degree in Management from Harvard University. Reza has been a member of the full-time Harvard faculty since 1995. As a clinician-scientist, he has a particular interest in the molecular and cellular mechanisms of inflammation as they pertain to the ocular surface and anterior segment pathologies, including dry eye, allergy, wound healing responses, and transplant rejection.
Affiliations and expertise
Schepens Eye Research Institute, Boston, MA, USAPD
Patricia D’Amore
Dr. D’Amore earned her PhD in Biology from Boston University, was a postdoctoral fellow in Biological Chemistry and Ophthalmology at Johns Hopkins Medical School, then moved to Boston Children’s Hospital as Assistant Professor where she remains Research Associate in Surgery. In 1998, she became Charles L. Schepens Professor of Ophthalmology and Professor of Pathology at Harvard Medical School and a Senior Scientist at Mass. Eye and Ear. She is the Associate Chief of Basic and Translational Research for Ophthalmology at Mass. Eye and Ear and the Vice Chair of Basic and Translational Research for the Department of Ophthalmology.
Dr. D’Amore is an international expert in vascular growth and development and has been at the forefront of angiogenesis research for over three decades. She has published more than 170 peer-reviewed papers, 75 reviews, and edited or co-edited two books.
Affiliations and expertise
Charles L. Schepens Professor of Ophthalmology,
Massachusetts Eye and Ear and Harvard Medical School,
Boston, MA ,USA