Immunobiology of COVID-19
- 1st Edition, Volume 202 - January 17, 2024
- Editor: Asiya Zaidi
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 2 8 4 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 2 8 5 - 8
Immunobiology of COVID19, Volume 202 in the Progress in Molecular Biology and Translational Science Series provides a comprehensive and in-depth exploration of the SARS-CoV-2 virus… Read more
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Request a sales quoteImmunobiology of COVID19, Volume 202 in the Progress in Molecular Biology and Translational Science Series provides a comprehensive and in-depth exploration of the SARS-CoV-2 virus and its impact on human health. Written by a team of expert contributors, the book covers various aspects of the virus, including its structure, lifecycle, and genomic replication. It delves into the epidemiology of COVID-19, comparing it with other related coronaviruses and discussing the concept of herd immunity. The structural biology of SARS-CoV-2 is examined, with a focus on techniques such as electron microscopy and cryo-electron tomography. The book also explores the biology of SARS-CoV-2 variants and their immune evasion strategies. Furthermore, it delves into the pathogenesis of COVID-19, examining its multiorgan manifestations and the long-term effects of the disease. The innate and adaptive immune responses to SARS-CoV-2 are discussed in detail, along with the role of B cells and T cells in the immune response. The volume concludes with a look at future insights and potential developments in the field. Accompanied by illustrative diagrams and visuals, this volume will serve as a valuable resource for researchers, healthcare professionals, and anyone interested in understanding the intricate details of SARS-CoV-2 and its impact on global health.
- Provides comprehensive coverage of various aspects of the COVID-19 pandemic, including virus structure, variants, immune responses, and disease pathogenesis, including its multiorgan manifestations and long COVID
- Focuses on in-depth analysis of innate and adaptive immune responses to SARS-CoV-2, including B cell and T cell responses
- Presents a richly illustrated resource with informative diagrams and visual aids to enhance understanding of complex concepts and structures related to COVID-19
Researchers and scientists in virology, immunology, and infectious diseases. Healthcare professionals, including doctors, nurses, and clinicians. Public health officials and policymakers. Graduate and postgraduate students in relevant fields of study. Academic institutions and libraries with a focus on medical and life sciences
- Cover image
- Title page
- Copyright
- Table of Contents
- Contributors
- Preface
- Chapter One: SARS-CoV-2—Virus structure and life cycle
- Abstract
- 1 Introduction
- 2 Virus classification
- 3 Coronaviruses
- 4 Structure of SARS-CoV-2
- 5 Viral genomic replication
- 6 Conclusion
- References
- Further reading
- Chapter Two: Epidemiology of COVID-19
- Abstract
- 1 Introduction
- 2 Comparison between SARS-CoV, MERS-CoV, and SARS-CoV-2
- 3 Concept of herd immunity
- 4 Changing epidemiology of SARS-CoV-2
- 5 Timelines and evolution
- References
- Chapter Three: Structural biology of SARS-CoV-2
- Abstract
- 1 Introduction
- 2 Electron microscopy
- 3 Xray crystallography
- 4 Cryo-Em imaging
- 5 Intracellular detection and tracking of SARS-CoV-2
- 6 How cryo-Em helped in delivering high-quality structural information of SARS-CoV-2
- 7 SARS-CoV-2 structural visualization
- 8 Nuclear magnetic resonance (NMR) spectroscopy
- Acknowledgments
- References
- Chapter Four: SARS-CoV-2 variant biology and immune evasion
- Abstract
- 1 Introduction
- 2 Ecological dynamics and viral evolution
- 3 Evolutionary dynamics of SARS-CoV-2
- 4 Transmission bottleneck
- 5 The evolutionary phases of the covid-19 pandemic
- 6 Origin of variants of concern (vocs) and the omicron variant
- 7 The role of furin cleavage site (FCS) in the emergence of SARS-CoV-2 variants
- 8 The role of structural and non-structural proteins in infectivity
- 9 Innate immunity evasion strategies by SARS-CoV-2 variants
- 10 Possibilities in the future
- Acknowledgments
- References
- Chapter Five: COVID-19 pathogenesis
- Abstract
- 1 Introduction
- 2 Risk factors and genetic predisposition
- 3 SARS-CoV-2—Multiorgan disease
- 4 Extrapulmonary manifestations of COVID-19
- 5 Multisystem manifestations of COVID-19
- References
- Chapter Six: Long Covid
- Abstract
- 1 Introduction
- 2 Definition
- 3 Manifestations of Long Covid
- 4 Hypotheses for Long Covid pathogenesis
- 5 Risk factors for Long Covid
- 6 Long Covid in children
- 7 Major findings of Long Covid
- 8 Diagnosis and treatment strategies
- References
- Chapter Seven: Innate immune responses to SARS-CoV-2
- Abstract
- 1 Introduction
- 2 Innate immune system basics
- 3 Innate immune response to SARS-CoV-2
- 4 Innate immunity evasion strategies by CoV-19
- 5 Conclusion
- References
- Chapter Eight: B cell responses to SARS-CoV-2
- Abstract
- 1 Introduction
- 2 Structure of SARS-CoV-2 and its impact on B cell immunity
- 3 Production and maturation of SARS-CoV-2-specific B cells
- 4 The interplay between B cells, follicular T helper cells, CD4+ T cells, and plasma cells
- 5 Concept of immunological memory
- 6 Antibody response in SARS-CoV-2 infection
- 7 Types of antibodies against infection
- 8 Role of mucosal antibodies
- 9 Role of cross-reactive antibodies
- 10 Role of auto-reactive antibodies
- 11 Factors affecting the dynamics of anti-SARS-CoV-2 antibodies
- 12 The omicron variant and humoral immune responses
- 13 Double negative B cells
- 14 Antibody dependant enhancement
- 15 Autoimmune antibodies
- 16 Immune evasion through various mutations
- References
- Further reading
- Chapter Nine: T cell responses to SARS-CoV-2
- Abstract
- 1 Introduction
- 2 T cell differentiation In COVID-19
- 3 Key points on Spike Protein immunology
- 4 Cellular immune responses against SARS-CoV-2 during acute infection
- 5 Specificity, phenotype, and function of SARS-CoV-2-specific T cell responses
- 6 T cell cross-recognition against other HCoVs
- 7 Mechanisms of regulation by Spike Proteins
- 8 T-cell responses to self-Spike Proteins
- 9 Spike Proteins as immunological targets in disease
- 10 Clinical trials in autoimmune diseases
- 11 Concluding remarks
- References
- Further reading
- Chapter Ten: Future insights
- Abstract
- 1 Introduction
- 2 How realistic is the “near end of the pandemic” prediction by the world health organization
- 3 What will be the status of long-term covid in 2023–2025
- Acknowledgments
- References
- Index
- No. of pages: 485
- Language: English
- Edition: 1
- Volume: 202
- Published: January 17, 2024
- Imprint: Academic Press
- Hardback ISBN: 9780443132841
- eBook ISBN: 9780443132858
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