Immunity, Cancer, and Chemotherapy

Basic Relationship on the Cellular Level

1st Edition - January 1, 1967
Editor: Enrico Mihich
Language: English
Paperback ISBN:
9 7 8 - 1 - 4 8 3 2 - 5 0 8 7 - 8
Hardback ISBN:
9 7 8 - 1 - 4 8 3 2 - 2 7 6 2 - 7
eBook ISBN:
9 7 8 - 1 - 4 8 3 2 - 5 9 0 0 - 0

Immunity, Cancer, and Chemotherapy focuses on the interference of drugs on antibody response and transplantation immunity. The selection first offers information on the effects… Read more

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Immunity, Cancer, and Chemotherapy focuses on the interference of drugs on antibody response and transplantation immunity. The selection first offers information on the effects of immunosuppressive drugs on cellular changes after antigenic stimulation and specialized cell function in the lymphoid and reticuloendothelial cell series. Topics include effects of immunosuppressive drugs on the sensitization process; cellular changes in lymphoid tissue following sensitization; and demonstration of differences in antigen handling among cells of the reticuloendothelial system. The text also takes a look at allogeneic inhibition and its possible relation to cell-bound immunity in vitro and the effects of immunosuppressive drugs at various stages of differentiation of immunologically competent cells. The publication examines a study of antibody-containing cells in the course of immunization and cellular differentiation during immune responses studied with electron microscope and radioautography. The text also elaborates on ambiguity in the translation of genetic code into proteins, induced by aminoglycoside antibiotics and immunosuppressive agents and cellular kinetics of immune response. The selection is a dependable source of information for readers interested in effects of drugs on antibody response and transplantation immunity.

articipants

List of Contributors

Foreword

Preface

The Effect Of Immunosuppressive Drugs On Cellular Changes After Antigenic Stimulation

I. Cellular Changes In Lymphoid Tissue Following Sensitization

II. Effect of Immunosuppressive Drugs on the Sensitization Process

III. Conclusions

References

Discussion

Specialized Cell Function In The Lymphoid And Reticuloendothelial Cell Series

I. Demonstration of Differences In Antigen Handling Among Cells of the Reticuloendothelial System

II. Specialization of Cells of the Lymphoid System

III. Concluding Remarks

References

Discussion

Allogeneic Inhibition And Its Possible Relation To Cell-Bound Immunity In Vitro

I. Attempts to Demonstrate Allogenic Inhibition in Vitro

II. Summary

Acknowledgments

References

Discussion

The Effect Of Immunosuppressive Drugs At Various Stages Of Differentiation Of Immunologically Competent Cells

I. Definition Of The Inductive Phase By The Use Of Metabolic Inhibitors

II. The Influence Of Metabolic Inhibitors On Antibody Production

III. The Influence Of Inhibitors On The Preparation For The Secondary Response

IV. The Influence Of Inhibitors On The Secondary Response

V. Studies On Immunological Inhibition (Tolerance) Using Metabolic Inhibitors

VI. Unitarian Concept Of Immune Reactions Based On The Model Of Immunological Cell Differentiation

References

Discussion

A Study Of Antibody-Containing Cells In The Course Of Immunization

I. Comparison Between The Results Obtained With The ICA And The Hemolysis Plaque Formation Techniques

II. Application Of The ICA Method To The Study Of Cells Producing Antibodies Against Haptens

III. Inhibition Of ICA By Heterologous Antibodies Against Immunoglobulins

IV. Kinetics Of The Appearance Of "Rosette"-Forming Cells In The Spleen Of Mice Immunized Intravenously With Sheep Erythrocytes

References

Discussion

Cellular Differentiation During Immune Responses Studied With The Electron Microscope And Radioautography

Text

References

Discussion

Concerning The Recognition Reaction And Transfer RNA In Protein Synthesis

Text

References

Discussion

Ambiguity In The Translation Of The Genetic Code Into Proteins, Induced By Aminoglycoside Antibiotics

Text

References

Discussion

Macrophage RNA And Antibody Synthesis

Text

References

Discussion

The Role Of Antigen In The Regulation Of Antibody Formation

I. Kinetics Of Antibody Formation To Bacteriophage φX 174 In Guinea Pigs

II. Immune Functions of Individual Antibody-Forming Cells

References

Discussion

Alteration Of Immunity By Antimetabolites

Text

References

Discussion

Immunosuppressive Agents And The Cellular Kinetics Of The Immune Response

I. Introduction

II. Materials And Methods

III. Results

IV. Discussion

V. Summary

References

Discussion

Immunochemical Studies Of Mammalian Cell Membranes

I. Introduction

II. The Immunochemical Problem

III. Methods For The Preparation Of Plasma Membranes

IV. Recognition Marker For Plasma Membrane

V. Composition Of Plasma Membrane Preparations

VI. General Discussion

References

Discussion

Tumor Antigens

Text

References

Discussion

Expression Of Antigens In Normal Mammalian Cells

I. Introduction

II. Cellular Antigens In Tissue Culture

III. Embryonic Differentiation Of Antigens

IV. Induction Of Antigens In The Thymus

V. Modification Of The Expression Of Normal Tissue Antigens In Vivo

VI. Differentiation Of Immunoglobulin-Producing Cells

VII. Closing Comments

References

Discussion

Mechanism Of Complement Action And Means Of Complement Depletion

I. Physiogenic And Pathogenic Role Of Complement

II. Mechanism Of Action Of Human Complement

III. Enhancement Of Complement

IV. Inhibition Of Complement

V. Inactivation Of C'3 By Cobra Factor

References

Discussion

Immunogenicity Of Synthetic Polymers Of Amino Acids; Role Of Carrier And Genetic Background

I. Introduction

II. Immunogenicity Of Linear Polymers Of α-L- And α-D-Amino Acids

III. Role Of Carrier In Influencing The Immune Response

IV. Genetic Control Of Immune Response

References

Discussion

Studies On Transplantation

I. Past Efforts

II. Causes Of Failure

III. Histocompatibility Matching

IV. Improved Immunosuppression

V. Other Organs

References

Discussion

Author Index

Subject Index

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Immunity, Cancer, and Chemotherapy

Basic Relationship on the Cellular Level

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