Hydrogels in Orthopaedic Tissue Engineering
Advances in Bone and Cartilage Regeneration
- 1st Edition - January 1, 2026
- Imprint: Woodhead Publishing
- Authors: Balaji Ayyanar Chinnappan, Elango Santhini, Trishna Bal, Faiza Sharif, N. S. Smrithi, Namrata Misra, Priyadarshini Pillai
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 3 6 7 6 7 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 3 6 7 6 8 - 7
Hydrogels in Orthopaedic Tissue Engineering: Advances in Bone and Cartilage Regeneration is a comprehensive evaluation of new and existing biomaterials transforming orthop… Read more
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Hydrogels in Orthopaedic Tissue Engineering: Advances in Bone and Cartilage Regeneration is a comprehensive evaluation of new and existing biomaterials transforming orthopedic care: in particular, it examines the science and application of hydrogels, showcasing their remarkable ability to mimic natural tissue environments, promote healing, and integrate seamlessly with the body. It reviews recent advances in hydrogel technology, including their design, synthesis, and functionalization for enhanced biocompatibility and mechanical properties. Each chapter provides an in-depth analysis of hydrogel-based strategies for repairing and regenerating bone and cartilage, addressing critical challenges such as vascularization, cell differentiation, and long-term stability. Through detailed case, the book offers invaluable insights for researchers, clinicians, and biomedical engineers
- Provides a comprehensive and up-to-date resource that bridges the gap between cutting-edge research and clinical application in the field of regenerative medicine
- By compiling real-world case studies, it addresses the urgent need for effective biocompatible solutions that can improve patient outcomes and advance the field of tissue engineering
- Addresses the critical problem of effectively treating bone and cartilage injuries, which are often challenging due to the limited capacity for natural healing and the complexity of these tissues
- Covers the design, synthesis, and application of hydrogels, detailing how these materials can be engineered to mimic the natural extracellular matrix, support vascularization, and deliver bioactive molecules that enhance tissue regeneration
Researchers in universities and research institutes involved in research on medicine, pharmacology and biomaterials
1. Introduction to hydrogels in regenerative medicine
2. Anatomy and physiology of bone and cartilage tissues
3. Pathologies and injuries requiring regeneration
4. Current challenges in bone and cartilage regeneration
4.1 Clinical applications of hydrogel-based therapies for specific bone or cartilage defects, highlighting patient outcomes and challenges encountered
4.2 Industrial development case studies, showcasing the journey from hydrogel design to commercialization of a medical device or therapy.
4.3 Research breakthroughs that demonstrate novel hydrogel formulations or fabrication techniques leading to improved regenerative outcomes in preclinical or clinical settings
4.4 Regulatory considerations and the commercial viability of hydrogel products
4.5 Patient outcomes and clinical trials of hydrogel-based therapies
5. Biomaterials for bone and cartilage tissue engineering
6. Hydrogel properties, types and design considerations for tissue engineering
6.1 Patient outcomes and clinical trials of hydrogel-based therapies
7. Design, fabrication and characterization of hydrogels for bone regeneration
7.1 Hydrogel synthesis and fabrication techniques, including chemical/physical crosslinking, 3d printing, and electro spinning.
7.2 Characterization methods for hydrogels, encompassing mechanical testing, chemical/structural analysis, and biological assessments.
7.3 In vitro and in vivo models for bone and cartilage regeneration, along with associated analytical techniques
8. Design fabrication and characterization of hydrogels for cartilage regeneration
9. Drug/cell encapsulation and delivery strategies in hydrogel systems
10. Cell-hydrogel interactions in tissue regeneration 11. Growth factors and signaling molecules in tissue engineering scaffold degradation and tissue integration
2. Anatomy and physiology of bone and cartilage tissues
3. Pathologies and injuries requiring regeneration
4. Current challenges in bone and cartilage regeneration
4.1 Clinical applications of hydrogel-based therapies for specific bone or cartilage defects, highlighting patient outcomes and challenges encountered
4.2 Industrial development case studies, showcasing the journey from hydrogel design to commercialization of a medical device or therapy.
4.3 Research breakthroughs that demonstrate novel hydrogel formulations or fabrication techniques leading to improved regenerative outcomes in preclinical or clinical settings
4.4 Regulatory considerations and the commercial viability of hydrogel products
4.5 Patient outcomes and clinical trials of hydrogel-based therapies
5. Biomaterials for bone and cartilage tissue engineering
6. Hydrogel properties, types and design considerations for tissue engineering
6.1 Patient outcomes and clinical trials of hydrogel-based therapies
7. Design, fabrication and characterization of hydrogels for bone regeneration
7.1 Hydrogel synthesis and fabrication techniques, including chemical/physical crosslinking, 3d printing, and electro spinning.
7.2 Characterization methods for hydrogels, encompassing mechanical testing, chemical/structural analysis, and biological assessments.
7.3 In vitro and in vivo models for bone and cartilage regeneration, along with associated analytical techniques
8. Design fabrication and characterization of hydrogels for cartilage regeneration
9. Drug/cell encapsulation and delivery strategies in hydrogel systems
10. Cell-hydrogel interactions in tissue regeneration 11. Growth factors and signaling molecules in tissue engineering scaffold degradation and tissue integration
- Edition: 1
- Published: January 1, 2026
- Imprint: Woodhead Publishing
- Language: English
BC
Balaji Ayyanar Chinnappan
Dr Balaji Ayyanar is an Assistant Professor at the Mechanical Engineering Department, Coimbatore Institute of Technology, India; Dr Ayyanar’s research interests include modelling, computer aided design, preparation of manufacturing drawings using Auto CAD, Modeling (Pro- E) and analysis of machine elements using FEM. He has written 18 publications in international journals, four book chapters and 24 papers in international and national conferences
Affiliations and expertise
Assistant Professor, Mechanical Engineering Department, Coimbatore Institute of Technology, IndiaES
Elango Santhini
Dr. E. Santhini is a Senior Scientific Officer at The South India Textile Research Association (SITRA), Coimbatore, India. She carried out her post-doctoral research at the Indian Institute of Science (IISc), Bangalore, India. She has over 10 years of experience in medical textiles
Affiliations and expertise
Senior Scientific Officer, The South India Textile Research Association, Coimbatore, IndiaTB
Trishna Bal
Dr Trishna Bal is currently an Assistant Professor at the Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, India. Her research interests include natural polymers, graft copolymers, hydrogel, polymer composites, wound healing and nanofiber materials
Affiliations and expertise
Assistant Professor, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, IndiaFS
Faiza Sharif
Dr Faiza Sharif is currently working as a Tenured Associate Professor at the Interdisciplinary Research Centre in Biomedical Materials, COMSATS University Islamabad, Lahore Campus, Lahore Pakistan. She has a long career in Biological Science. She gained her PhD from Leiden University the Netherlands in 2011 and Post Doctorate from the Department of Materials Science and Engineering, University of Sheffield UK in the field of biomedical materials and tissue engineering. She has been working in the field for over 10. Her research interests include development of degradable biomedical materials for treatment of hard and soft tissue defects
Affiliations and expertise
Tenured Associate Professor, Interdisciplinary Research Centre in Biomedical Materials, COMSATS University Islamabad, Lahore Campus, Lahore PakistanNS
N. S. Smrithi
Dr. N. S. Smrithi is currently pursuing her third year of Prosthodontics Senior Residency from The Tamil Nadu Dr M.G.R Medical University and has wide expertise in the field of Prosthodontics and Implantology. She completed her Bachelors in Dental Surgery from The Tamil Nadu Dr M.G.R Medical University (Sri Ramakrishna Dental College) in 2022. Her current research areas include hydrogels, dental material sciences and Implantology
Affiliations and expertise
RVS Dental College, IndiaNM
Namrata Misra
Dr Misra has a decade of experience in contributing to the innovation and startup ecosystem in various capacities at KIIT TBI. She is currently serving as Chief Executive Officer since Aug 2023 in Bhubaneswar City Knowledge Innovation Cluster, an initiative of the Office of the Principal Scientific Adviser to the Government of India
Affiliations and expertise
KIIT School of Biotechnology, IndiaPP
Priyadarshini Pillai
Dr Priyadarshini Pillai is an Assistant Professor and Head of Department at Jyoti Nivas College, Bangalore, a position she has held since May 2017. Her earlier roles include Project Scientist at the R.K. Institute of Management and Computer Science (June 2012 - April 2014) and Research Scientist at GVK Bio-campus (December 2007 - May 2012. Dr Pillai began her academic career as a Lecturer and Research Scholar at Vikram University (July 2003 - December 2006) and as a Lecturer at Government Madhav Science College
Affiliations and expertise
Assistant Professor and Head of Department, Jyoti Nivas College, Bangalore, India