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Elsevier

Human Reproductive Genetics

Emerging Technologies and Clinical Applications

  • 1st Edition - April 19, 2020
  • Latest edition
  • Editors: Juan A. Garcia-Velasco, Emre Seli
  • Language: English

Human Reproductive Genetics: Emerging Technologies and Clinical Applications presents a great reference for clinicians and researchers in reproductive medicine. Part I includes… Read more

Description

Human Reproductive Genetics: Emerging Technologies and Clinical Applications presents a great reference for clinicians and researchers in reproductive medicine. Part I includes a brief background of genetics and epigenetics, probability of disease, and the different techniques that are being used today for analysis and genetic counseling. Part II focuses on the analysis of the embryo, current controversies and future concepts. Part III comprises different clinical scenarios that clinicians frequently face in practice. The increasing amount of genetic tests available and the growing information that patients handle makes this section a relevant part of the fertility treatment discussion.

Finally, Part IV concludes with the psychological aspects of genetic counseling and the role of counselor and bioethics in human reproduction.

Key features

  • Provides an essential reference for clinicians involved in reproductive medicine
  • Builds foundational knowledge on new genetic tests coming into the clinical scenario for physicians involved with patients
  • Assembles critically evaluated chapters that cover basic concepts of genetics and epigenetics and the techniques involved, including preimplantation genetic testing, controversies, and more

Readership

Active researchers, basic and translational scientists, clinicians, and students in the areas of reproductive medicine, gynecology, obstetrics, andrology, embryology, endocrinology human genetics, genomics, bioinformatics, prenatal testing, and genetic testing; genetic counselors; bioethicists; fertility specialists

Table of contents

1. Basic Genetics: Mitosis, Meiosis, Chromosomes, DNA, RNA and Beyond
Amanda Kallen

2. Identification of Genetic Causes of Gynecologic Disorders
Maria Lalioti

3. Cytogenetics
Inmaculada Campos

4. Molecular biology approaches utilized in pre-implantation genetics: real time PCR, microarrays, next generation sequencing, karyomapping, and others
Patricia Diaz Gimeno

5. Epigenetics and Imprinting In ART
Emre Seli

6. The Quest for Genetic Sequence Variants Conferring Risk of Endometriosis
Sun-Wei Guo

7. Genetics of PCOS
Joop Laven, and Yvonne Louwers

8. Male Factor Infertility: Genetic and Epigenetic Aspects
Jim Hotaling

9. Mitochondrial Genetics
Elpida Fragouli

10. Endometrial Receptivity and Genetics
Nick Macklon

11. Genetics of Reproductive Aging and POF
Juan Antonio Velasco

12. Prenatal Testing
Joshua Copel, Katherine Kohari, Audrey Merriam

13. Carrier Testing in Reproductive Medicine
Jeffrey Dungan

14. PGT-A (PB, Day 3, Day 5…)
Richard Scott

15. Future Technologies for Pre-Implantation Genetic Applications
Dagan Wells

16. Counseling: Psychology of Genetic Diagnoses
Dorothy Greenfeld

17. Bioethics in Human Reproduction
Guido Pennings and Heidi Mertes

18. The Role of Genetic Counseling in the Infertile Patient
Josep Pla-Victori

Review quotes

"This is a wonderful first edition in a new and rapidly expanding field of human reproductive genetics. It is a useful book for its narrow-intended audience. It is an excellent resource for students, residents, and fellows. The wide range of contributors from across the globe adds to the book's fund of knowledge. I see this becoming an important resource to have in the future and I hope the authors will be able to keep it up to date given the evolving nature of the content."—Doody

Product details

  • Edition: 1
  • Latest edition
  • Published: April 24, 2020
  • Language: English

About the editors

JG

Juan A. Garcia-Velasco

Juan García-Velasco is Director of IVI Madrid. He is also Professor of Obstetrics and Gynaecology at Rey Juan Carlos University, Madrid, Spain, where he is Director of their Master’s Degree Programme in Human Reproduction. He graduated from University Medical School, Madrid, in 1990 and received his Obstetrics and Gynecology certification from La Paz Hospital, Madrid, in 1995. He completed his PhD in Medicine from Autonoma University, Madrid, in 1995 and from 1997 to 1998 he studied at Yale University, New Haven, CT, under a Reproductive Endocrinology and Infertility Fellowship. His main research interests have been in IVF and endometriosis. He is the Principal Investigator of projects funded by the Ministry of Education and Ministry of Health, Spain, and has received awards from the Spanish Fertility Society, Spanish Society of Obstetrics and Gynecology, and the European Society of Human Reproduction and Embryology. He has published over 200 peer‐reviewed articles as well as 22 book chapters on human reproduction, endometriosis and hypo‐ and hyper‐ovarian stimulation response and is the author/editor of several books.
Affiliations and expertise
Professor of Obstetrics and Gynecology, Rey Juan Carlos University, Madrid, Spain Director IVI RMA - Madrid, Spain

ES

Emre Seli

Dr. Seli is Professor of Obstetrics, Gynecology, and Reproductive Sciences at Yale School of Medicine and Chief Scientific Officer at IVIRMA Global. He received his medical degree from the University of Istanbul and completed his Residency in Obstetrics and Gynecology at Yale University. His postdoctoral training included a fellowship in Reproductive Endocrinology and Infertility as well as a research fellowship in molecular biology, both at Yale University. As a physician-scientist, his primary focus is to understand and treat infertility. His laboratory characterized the mechanisms regulating translational activation of gene expression in the oocyte. Dr. Seli and his colleagues also made seminal contributions to our understanding of oocyte and embryo competence in IVF and the potential role of non-invasive diagnostic technologies in this context. Dr. Seli is the recipient of many National Institutes of Health (NIH) and pharmaceutical industry-sponsored research grants as well as numerous awards, including the Ira and Ester Rosenwaks New Investigator Award, American Society for Reproductive Medicine (ASRM) and the President’s Achievement Award from the Society for Reproductive Investigation (SRI).
Affiliations and expertise
Professor of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine

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