Human Organs-on-a-Chip

Novel Organ-on-a-Chip Techniques in Medicine

1st Edition - November 13, 2023
Imprint: Academic Press
Authors: Javier Ramón-Azcón, Artur Rydosz
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 3 8 4 - 6
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 3 8 5 - 3

Human Organs-on-Chip: Novel Organ-on-a-Chip Techniques in Medicine paves the way for novel approaches that push forward in-vitro and in-vivo studies and fills a gap between l… Read more

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Human Organs-on-Chip: Novel Organ-on-a-Chip Techniques in Medicine paves the way for novel approaches that push forward in-vitro and in-vivo studies and fills a gap between laboratory and clinical use. The book's experienced authors share the knowledge they’ve developed with over a decade of research with organ-on-chips and multi-organ-on-chips. The book collects all of the developments in the field and sheds new light on possibilities to develop human on-chip measurement methods with the utilization of currently available measurement techniques including both invasive and non-invasive tests. This book will serve as a starting point for young researchers who are beginning their scientific journeys.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Acknowledgements
Chapter 1. Introduction
1.1. Introduction
1.2. The difference between cells in 2D and 3D applications
1.3. 3Rs transform to 4Rs
1.4. The concept of the organ-on-a-chip
1.5. Concept of the human-on-a-chip
1.6. Conclusions
Chapter 2. Technology for organ-on-chip applications
2.1. Introduction
2.2. Integration with other technologies
2.3. Conclusions
Chapter 3. Microfluidic technology in organ-on-a-chip applications
3.1. Introduction
3.2. The fabrication of microfluidic devices
3.3. Modelling and simulations
3.4. Conclusions
Chapter 4. Fundamentals
4.1. Introduction
4.2. Conclusions
Chapter 5. Measurement and analytical techniques
5.1. Introduction
5.2. Sensors in organ-on-a-chip platforms
5.3. Measurement techniques
5.4. Molecular recognition method
5.5. Conclusions
Chapter 6. Major on-chip applications
6.1. Introduction
6.2. Pancreas-on-chip
6.3. Muscle-on-chip
6.4. Liver-on-chip
6.5. Heart-on-chip
6.6. Blood vessel-on-chip
6.7. Lung-on-chip
6.8. Kidney-on-a-chip
6.9. Skin-on-chip
6.10. Others
6.11. Miscellaneous
6.12. Cancer-on-a-chip or tumour-on-a-chip
6.13. Conclusions
Chapter 7. Multi-organ-on-chip applications
7.1. Introduction
7.2. Drug toxicity and efficacy profiling using multi-organ-on-chip platforms
7.3. Metabolic crosstalk
7.4. Conclusions
Chapter 8. Organ-on-chip-based disease models
8.1. Introduction
8.2. Skeletal–muscle disease models
8.3. Metabolic disease models
8.4. Conclusions
Chapter 9. Commercial achievements resulting from multi-organ-on-a-chip applications
9.1. Introduction
9.2. Pharmacokinetic and pharmacodynamic models with organ-on-a-chip devices
9.3. Organ-on-a-chip impact on drug development
9.4. Drug development to target civilisation diseases
9.5. Drug development to target rare diseases
9.6. Organ-on-a-chip implementation for the development of antibiotics
9.7. Organ-on-a-chip implementation for cosmetics
9.8. Adverse drug reaction
9.9. High-throughput drug screening
9.10. Death Valley of commercialisation
9.11. Regeneration medicine
9.12. Conclusions
Chapter 10. Further perspectives – New drugs, new tissues, new organs
10.1. Introduction
10.2. New drugs
10.3. New tissues/cells
10.4. Further perspectives
10.5. Conclusions
Chapter 11. Conclusions
Index

Javier Ramón-Azcón

In 2011, Prof. Javier Ramón-Azcón was hired by the Advanced Institute for Materials Research (AIMR) at Tohoku University (Japan) as Assistant Researcher to develop new biomaterials with engineered tissue. After two years, he was promoted to Assistant Professor in AIMR, leading a research group focused on integrating biosensor technology with stem cell, biomaterials, and tissue engineering. In 2017, he became Junior Group Leader at the Institute of Bioengineering of Catalonia (IBEC) after obtaining the prestigious ERC- Starting Grant. In 2020, he was appointed Professor by the Institució Catalana de Recerca i Estudis Avançats (ICREA) and Senior Group Leader based on their successful and promising scientific trajectory. From 2017 and 2020, he has attracted more than €3.5M in competitive funding, including the coordination of a FET-Open project. Currently, he is supervising five postdocs, for Ph.D. students, and three MSC students

Affiliations and expertise

ICREA Research Professor, Institute of Bioengineering of Catalonia, Barcelona, Spain

Artur Rydosz

Artur Rydosz received his degrees in electronics engineering from the AGH University of Science and Technology, Krakow, Poland. In 2019 he obtained D.Sc. degree and since 2023 is a full professor at the Institute of Electronics AGH. His current research interests include gas sensors and organ-on-a-chip platforms. He's also interested in the PVD method of the fabrication of various sensing materials with a special emphasis on the detection of volatile organic compounds in exhaled human breath, for example, as a potential tool for the noninvasive measurement of several diseases, such as diabetes; as well as metallic layers for SPR-based sensors for gas-sensing and bio-sensing applications. Prof. Rydosz serves as the Vice-Chair of the Joint Chapter AP03/AES10/MTT17, IEEE Poland Section and is the Head of the Biomarkers Analysis LAB. In 2022, his book entitled Diabetes Without Needles (Elsevier) was published.

Affiliations and expertise

Postdoctoral Researcher, Institute for Bioengineering of Catalonia (IBEC), Spain; Professor, AGH University of Science and Technology, Poland

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health