Human Microbiome in Health and Disease - Part A

1st Edition, Volume 191 - September 23, 2022
Editors: Bhabatosh Das, Vijai Singh
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 7 8 6 - 7
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 7 8 7 - 4

Human Microbiome in Health and Disease, Volume 191, Part A presents updated knowledge on human microbiome as covered by renowned science faculty across the globe. Chapters… Read more

Human Microbiome in Health and Disease - Part A

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Human Microbiome in Health and Disease, Volume 191, Part A presents updated knowledge on human microbiome as covered by renowned science faculty across the globe. Chapters in this volume include an introduction to human microbiome, Structure, functions and diversity of healthy human microbiome, Role of human microbiome in cancer, Gut microbiota and gastrointestinal cancer, Dysbiosis of human microbiome and metabolic diseases, Gut microbiome and type 2 diabetes, Gut microbiome and non-alcoholic fatty liver disease, Hepatic drug metabolism and intestinal microbiota, Emerging tools for understanding the human microbiome, and Microbiome therapeutics: Opportunity and challenges, and more.

These chapters cover the composition, diversity, dynamics and functions of human microbiome in health and disease. This book will form an excellent and informative text on keystone, autochthonous, and exogenous microbiota important for human health in a simple to understand and easy to read format.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter One: An introduction to human microbiome
Abstract
1: Introduction
2: Microbiome in different sites of human body
3: Microbiome diversity and dynamics
4: Key functions of microbiome in human physiology
5: Microbiome dysbiosis and associated diseases
6: Perspectives
Acknowledgment
Author contributions
Funding
Conflict of interest
7: Conclusion
References
Further reading
Chapter Two: Emerging tools for understanding the human microbiome
Abstract
1: Introduction
2: Questions addressed in a microbiome investigation
3: The advent of long-read and hybrid NGS
4: State-of-the-art data-analysis methodologies
5: Integrated OMICs for the microbiome
References
Chapter Three: Structure, functions, and diversity of the healthy human microbiome
Abstract
1: Introduction
2: Compositions and diversity of human microbiome
3: Functional diversity of human microbiome
4: Factors that modulate microbial diversity
5: Microbiome diversity-associated health disorders
6: Conclusion
Acknowledgments
References
Chapter Four: An overview of cancer and the human microbiome
Abstract
1: Introduction
2: Microbiome associated with cancers
3: Bacterial mechanisms of carcinogenesis
4: Virome and cancer
5: Parasites in cancer development
6: System biology tools to understand the complexity of human cancer microbiome interactions
7: A snapshot of microbial therapeutic approach in cancer
8: Future perspectives and challenges
9: Conclusions
Acknowledgments
Appendix A
Appendix B
References
Chapter Five: Gut microbiota in gastrointestinal diseases
Abstract
1: Introduction
2: Composition and identification of gut microbiota
3: Gastrointestinal diseases
4: Conclusion and future remarks
Acknowledgment
References
Chapter Six: Gut dysbiosis and metabolic diseases
Abstract
1: Introduction
2: The metabolic syndrome
3: Diet-mediated alteration of gut microbial population regulates obesity and associated metabolic syndrome
4: The triad of host genetics, gut dysbiosis and metabolic derangements
5: Circadian changes in gut microbiota and metabolic syndrome
6: Changes in the immune landscape in metabolic syndrome
7: Gut microbe derived metabolites in MetS progression
8: Gut microbial signature in type 2 diabetes mellitus
9: Gut microbial signature in NAFLD and NASH
10: Gut microbial signature in atherosclerosis
11: Promise of fecal microbiota transfer in metabolic diseases
12: Conclusion
References
Chapter Seven: Gut microbiome and type 2 diabetes
Abstract
1: Introduction
2: Involvement of bacterial bi-products
3: Prevention/treatment strategy involving microflora alterations by pre-biotic and pro-biotic
4: Conclusion and future remarks
References
Chapter Eight: Gut microbiome and non-alcoholic fatty liver disease
Abstract
1: Introduction
2: The healthy gut microbiome
3: The detangling metabolic disorder: NAFLD and its prevalence
4: The culprit of NAFLD: Gut dysbiosis
5: Microbiome signatures and their functional aspect
6: Lean NASH—An intriguing aspect
7: The fungal mycobiome—A synchronized component of the gut microbiome
8: The microbiome: Promising target to treat NASH
9: Conclusions and perspectives
Acknowledgments
Conflict of interest
References
Chapter Nine: Hepatic drug metabolism and gut microbiome
Abstract
1: Introduction
2: Gut microbiota composition and its association with diseases
3: Drug metabolism pathways
4: Gut microbiota modulating drug metabolism
5: Factors affecting the metabolism of drugs
6: Causes and imperative measures to tackle gut microbiota dysbiosis
7: Measures
8: Conclusion and perspective
Acknowledgments
Declaration
References
Chapter Ten: Microbiome-based therapeutics: Opportunity and challenges
Abstract
1: Introduction
2: Homeostasis and dysbiosis of human microbiome
3: Microbiome-based therapies
4: Microbiome as therapeutics in metabolic diseases
5: Microbiome as therapeutics in infectious diseases
6: Conclusion and future perspective
References
Index

Bhabatosh Das

Dr Bhabatosh Das is an Associate Professor in Translational Health Science and Technology Institute, an autonomous institute of the Department of Biotechnology, Government of India. He received his MSc degree (2000) from Visva-Bharati University, MTech degree (2002) from IIT-Kharagpur and PhD (2008) from IICB-Kolkata. He moved to France for his postdoctoral training and joined I2BC, France. Dr. Das is recipient of two international fellowships (i) CNRS, Govt. of France (ii) JSPS, Govt. of Japan and three national fellowships (i) IIT (ii) ICMR (iii) CSIR, Govt. of India. He has published 71 research articles 12 book chapters and received more than 2150 citations. Currently, he is Adjunct Visiting Faculty at MAHE-Manipal; Visiting Faculty at NIPER-Guwahati; Adjunct Faculty at RCB-Faridabad; Guest Lecturer at AIIMS-New Delhi. Dr. Das is Editorial Board Member in (i) Microbial Ecology (Springer group) (ii) Gut Microbiome (Cambridge University Press) and (iii) Current Indian Science (Bentham Science). He is guest associate editor in (i) Frontiers in Microbiology (ii) Frontiers in Genetics and (iii) Progress in Molecular Biology and Translational Research. He is a member in (i) GTFCC, WHO (ii) The Nutrition Society, London, UK and (iii) American Society for Microbiology, USA (Former). His current research focuses is Human microbiome and Bacterial antimicrobial resistance.

Affiliations and expertise

Associate Professor, Translational Health Science and Technology Institute (THSTI), NCR-BSC, India

Vijai Singh

Dr Vijai Singh is a Professor and Dean (Research & Innovation) at School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. He was an Associate Professor in the Department of Biosciences, School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. Prior this this, he was an Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, India and also an Assistant Professor in the Department of Biotechnology at the Invertis University, Bareilly, India. Prior to that, he was a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He received his Ph.D. in Biotechnology from the National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India with a research focus on the development of molecular and immunoassays for diagnosis of Aeromonas hydrophila. His research interests are focused on building novel biosynthetic pathways for production of medically and industrially important biomolecules. Additionally, his laboratory is working on CRISPR-Cas9 tools for genome editing. He has more than 11 years of research and teaching experience in synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has published 100 articles, 70 chapters, 15 books and 3 patents. He serves as an associate editor, editorial board member, and reviewer of several peer-reviewed journals. He is also a member of the Board of Study and Academic Council of Indrashil University and is the Member Secretary of the Institutional Biosafety Committee (IBSC) at the same University.

Affiliations and expertise

Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, India

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health