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Human Chorionic Gonadotropin (hCG)

Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to pr… Read more

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Description

Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs.

The book describes the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions.

Key features

  • It provides comprehensive information on hCG from basic science to clinical medicine

  • Written by specialists in the field

Readership

Researchers and clinicians in obstetrics, gynecology, clinical chemistry, endocrinology, reproductive medicine and oncology

Table of contents

INTRODUCTION

Chapter 1: THE EXPANDING WORLD OF hCG

Robert Hussa

Chapter 2: HISTORY AND INTRODUCTION TO HUMAN CHORIONIC GONADOTROPIN (hCG): ONE NAME FOR AT LEAST THREE INDEPENDENT MOLECULES Laurence Cole

Chapter 3: INTRODUCTION TO PREGNANCY IMPLANTATION, VILLOUS FORMATION, AND HEMOCHORIAL PLACENTATION Laurence Cole

GENETICS, SYNTHESIS, SECRETION, STRUCTURE, AND DEGRADATION OF hCG

Chapter 4: THE MOLECULAR GENETICS OF hCG Stephen Butler

Chapter 5: STRUCTURE, SYNTHESIS, SECRETION, AND FUNCTION OF hCG Laurence Cole, PhD and Stephen Butler

Chapter 6: COMPARISSON OF STRUCTURES OF hCG AND HYPERGLYCOSYLATED hCG Laurence Cole

Chapter 7: STRUCTURES OF FREE α-SUBUNIT AND FREE ß-SUBUNIT Laurence Cole

Chapter 8: GLYCOBIOLOGY OF hCGAkira Kobata

Chapter 9: DEGRADATION PRODUCTS OF hCG, HYPERGLYCOSYLATED hCG, AND FREE ß-SUBUNITLaurence Cole

Chapter 10: THE THREE DIMENSIONAL STRUCTURE OF hCGLaurence Cole

BIOLOGICAL FUNCTION OF hCG

Chapter 11: PARADIGM SHIFT ON THE TARGETS OF hCG ACTIONS

CV Rao

Chapter 12: THE hCG RECEPTOR

Laurence Cole and Stephen Butler

Chapter 13: BIOLOGICAL FUNCTIONS OF HYPERGLCOSYLATED hCGLaurence Cole

Chapter 14: BIOLOGICAL FUNCTION OF THE FREE BETA SUBUNIT: EXPRESSION AND TREATMENT TARGET IN CANCER

Steven Butler and Ray Iles

CLINICAL APPLICATIONS

Chapter 15: USE OF hCG IN REPRODUCTIVE DYSFUNCTIONCisco Byrn

Chapter 16: hCG IN THE IVF CLINICErvin Jones,

Chapter 17: ILLICIT USE OF hCG IN DIETARY PROGRAMS AND USE TO PROMOTE ANABOLISM Laurence Cole

hCG TESTS

Chapter 18: ANTIBODYS FOR INTACT hCG, TOTAL hCG, FREE SUBUNITS, GLYCOSYLATION VARIANTS, AND hCG FRAGMENTSLaurence Cole

Chapter 19: QUANTITATIVE hCG ASSAYSLaurence Cole

Chapter 20: FALSE-POSITIVE hCG ASSAYS Laurence Cole

Chapter 21: SPECIFICITY OF DIFFERENT hCG ASSAYSLaurence Cole

Chapter 22: POINT-OF-CARE PREGNANCY TESTS Laurence Cole

Chapter 23: OVER-THE-COUNTER PREGANCY TESTS Laurence Cole

Chapter 24: hCG STANDARDS Ulf Stenman

TEST APPLICATIONS

Chapter 25: BACKGROUND hCG Laurence Cole

Chapter 26: PREGNANCY TESTINGLaurence Cole

Chapter 27: PREDICTING SPONTANEOUSLY ABORTED (SAB) PREGNANCIES Laurence Cole

Chapter 28: hCG, HYPERGLYCOSYLATED hCG, AND FREE ß-SUBUNIT IN PREDICTING DOWN SYNDROME PREGNANCIES AND PREECLAMPSIA Laurence Cole

Chapter 29: hCG IN MONITORING GESTATIONAL TROPHOBLASTIC DISEASES

Laurence Cole

Chapter 30: USE OF HYPERGLYCOSYLATED hCG AS A UNIQUE MARKER OF GESTATIONAL TROPHOBLASTIC NEOPLASMS

Laurence Cole and Carolyn Muller

Chapter 31: PITUITARY hCG AND FAMILIAL hCG Laurence Cole

Chapter 32: hCG, FREE ß-SUBUNIT AND ß-CORE FRAGMENT AS MARKERS OF MALIGNANCIES Laurence Cole

BASIC METHODS

Chapter 33: hCG AND HYPERGLYCOSYLATED HCG PURIFICATION FROM SERUM, URINE, AND CULTURE FLUIDS

Laurence Cole

Chapter 34: DISSOCIATION, DESIALYLATION, AND CLEAVAGE OF HCG

Laurence Cole

Chapter 35: hCG AND FREE ß-SUBUNIT PRODUCING CELL LINES

Laurence Cole

EVOLUTION, SUMMARY AND THE FUTURE

Chapter 36: EVOLUTION OF hCG, EVOLUTION OF HUMANS, EVOLUTION OF HUMAN PREGNANCY DISORDERS AND CANCERLaurence Cole

Chapter 37: SUMMARY: hCG A REMARKABLE MOLECULELaurence Cole

Chapter 38: hCG AND THE FUTURE Laurence Cole

Product details

About the author

LC

Laurence A. Cole

Dr. Cole has served on the journal editorial board from 1994-2001 as the Editor of "Trophoblast Disease Update". He has written more than 100 articles on hCG structure, physiology and immunoassay and on clinical applications of hCG or hCG-related molecules. He has a 1.17 FWCI in the Medicine category of SciVal where he has published throughout the various disciplines and maintains an average of 12.6 citations per article from 2009-2014. He has experience with international, single, and institutional collaboration. Awards and recognition for Dr. Cole include the Institute for Anticancer Research, Biannual Prize for best research; American Association for Clinical Chemistry, Most Outstanding Research Contributor to Clinical Chemistry Prize; Gynecology Oncology, Outstanding Speaker Award; and International Society for Study of Trophoblastic Disease, Gold Medal for most outstanding research.
Affiliations and expertise
Director, USA hCG Reference Service, Santa Fe, New Mexico, USA

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