Human and Related Viruses

List of Contributors

Preface

Contents of Volume I

Part I Unclassified Viruses

Chapter 1 Marburg Virus Disease

I. Introduction

II. Description of Virus

III. Comparative Biology

IV. Immunity

V. Epidemiology

VI. Comparative Diagnosis

VII. Prevention and Control

References

Chapter 2 Diagnosis of Hepatitis Viral Infections

I. Introduction

II. The Pathology of Viral Hepatitis

III. Hepatitis B

IV. Hepatitis A

V. Immunization against Hepatitis

References

Chapter 3 Slow Virus Infections: Comparative Aspects and Diagnosis

I. Introduction

II. Progressive Multifocal Leukoencephalopathy

III. Subacute Sclerosing Panencephalitis

IV. Creutzfeldt-Jakob Disease

V. Concluding Remarks

References

Part II Cancer Viruses

Chapter 4 Human Proliferative Diseases and Viruses

I. Introduction

II. Viruses Associated with Neoplasia of Animals

III. Biochemical and Molecular Methods in Studies of Viral Involvement in Animal and Human Neoplasia

IV. Search for Human Tumor Viruses

V. Molecular and Biochemical Studies in Human Neoplasia

VI. Immunological Approaches to the Study of Viruses in Human Neoplasia

VII. Herpesviruses and Human Neoplasia

VIII. Concluding Remarks

References

Part III Control of Viral Diseases: Vaccines and Chemotherapy

Chapter 5 Control of Viral Diseases by Vaccines

I. Introduction

II. Vaccines in Current Use

III. Combined and Simultaneous Administration of Viral Vaccines

IV. Immunization Practices against Viral Diseases in the United States and Canada

V. Immunization Recommendations for Travelers

VI. Prospects for New Viral Vaccines

References

Chapter 6 Chemotherapy of Viral Diseases: Present Status and Future Prospects

I. Introduction

II. General Considerations

III. Nucleoside Analogs

IV. The Interferons

V. Miscellaneous Antivirais

VI. Immune Potentiators

VII. Antiviral Perspectives

References

Part IV Virus Information System

Chapter 7 The World Health Organization Virus Information System

I. Introduction

II. Development of the Reporting System

III. Objectives

IV. Data Input from Laboratories

V. Limitations to the Input

VI. Data Processing

VII. Output

VIII. Limitations of the Output

IX. Noncomputerized Information

X. Information System for Influenza Surveillance

XI. Use of Excess Mortality from Respiratory Diseases in the Study of Influenza

XII. Arboviruses, Rickettsiae, and Chlamydiae

XIII. Future of the WHO Virus Reporting System

XIV. World Health Organization [Collaborating Centres (Virus Diseases)]

References

Part V Diagnostic Reagents and Newer Methods

Chapter 8 Viral Diagnostic Reagents

I. Introduction

II. Historical Background

III. Inactivation

IV. Adenoviruses

V. Herpesvirus hominis (Simplex)

VI. Varicella-Zoster Virus

VII. Cytomegaloviruses

VIII. Poxviruses

IX. Orthomyxoviruses (Influenza)

X. Paramyxoviruses (Parainfluenza)

XI. Mumps

XII. Measles

XIII. Respiratory Syncytial Virus

XIV. Arboviruses

XV. Rubella

XVI. Rotaviruses (Infantile Gastroenteritis Virus)

References

Chapter 9 Immunoperoxidase Technique in Diagnostic Virology and Research: Principles and Application

I. Introduction

II. Reagents

III. Methods of Conjugation

IV. Procedures for Detection of Viral Antigens in Cells

V. Applications and Perspectives in Diagnosis and Research

VI. Conclusions

References

Chapter 10 Enzyme Immunoassays and Their Potential in Diagnositc Virology

I. Introduction

II. Materials and Methods

III. Results

IV. Conclusions

References

Chapter 11 Radioimmunoassay in Viral Diagnosis

I. Introduction

II. Methods and Reagents

III. Applications

References

Chapter 12 Cytohybridization Techniques in Virology

I. Introduction

II. Basic Principles of Hybridization

III. Requirements in Cytohybridization

IV. Preparation of the Radioactive Probes

V. Procedures for in Situ Hybridization

VI. Applications in Research and Diagnosis

VII. Conclusions and Prospects

VIII. Glossary

References

Chapter 13 Electron and Immunoelectron Microscopic Procedures for Diagnosis of Viral Infections

I. Introduction

II. Establishing an EM Unit for Virology

III. Direct Examination of Clinical Specimens by Negative Staining

IV. Direct Examination of Clinical Specimens by Thin Sectioning

V. Identification of Viruses Isolated in Tissue Cultures, Eggs, and Animals

VI. Screening Cell Cultures and Virus Pools for Adventitious Agents

VII. Immunoelectron Microscopy

VIII. Safety Precautions

References

Index