How to Optimize Fluid Bed Processing Technology

Chapter 1. Introduction

• Abstract
• 1.1 Introduction
• 1.2 Advantages and Challenges of Fluidized Bed Granulation

Chapter 2. Fluidization Theory

• Abstract
• 2.1 How Does Fluidization Take Place?
• 2.2 Understanding the Particles
• 2.3 Types of Fluid Beds
• 2.4 Controlling Gas Velocity
• 2.5 Addressing Fluidization Challenges
• 2.6 Summary
• References

Chapter 3. Fluid Bed Processor Equipment and Its Functionality

• Abstract
• 3.1 Introduction
• 3.2 Questions Before Specifying the Equipment
• 3.3 Fluid Bed Processor Components
• 3.4 Summary

Chapter 4. Process Development

• Abstract
• 4.1 Process Selection
• 4.2 Quality by Design
• 4.3 Processing in Fluid Bed
• 4.4 Risk Assessment and Management
• 4.5 Process Control
• 4.6 Case Study
• 4.7 Summary
• Reference

Chapter 5. Granulation

• Abstract
• 5.1 Theory
• 5.2 Binders
• 5.3 Nozzles
• 5.4 Process Parameters
• 5.5 Challenges in Fluid Bed Granulation
• 5.6 Granulation End Point
• 5.7 Granulation Characterization
• 5.8 Summary
• References

Chapter 6. Drying

• Abstract
• 6.1 Theory
• 6.2 Drying Granulated Product
• 6.3 Summary
• References

Chapter 7. Coating

• Abstract
• 7.1 Introduction
• 7.2 Top-Spray Coating
• 7.3 Wurster Coating
• 7.4 Other Coating Modules
• 7.5 Dry Powder Coating
• 7.6 Problems in Coating in Fluid Bed
• 7.8 Characterization of the Coating
• 7.9 Selection of the Process for Coating
• 7.10 Summary
• References

Chapter 8. Pelletization

• Abstract
• 8.1 Introduction
• 8.2 Pelletization With Wurster Coating Module
• 8.3 Pelletization in Rotary Fluid Bed
• 8.4 Case Studies
• 8.5 Characterization of Pellets
• 8.6 Summary
• References

Chapter 9. Other Fluid Bed Processes and Applications

• Abstract
• 9.1 Introduction
• 9.2 Fluidized Hot Melt Granulation (FHMG)
• 9.3 Spray Congealing
• 9.4 Pressure Swing Granulation (PSG)
• 9.5 Wurster Module for Granulation
• 9.6 Foam Granulation
• 9.7 Steam Granulation
• 9.8 Rotary Fluid Bed Agglomeration
• 9.9 Spray-Drying Granulation
• 9.10 Continuous Granulation
• References

Chapter 10. Process Control and PAT

• Abstract
• 10.1 Background
• 10.2 Process Control
• 10.3 Temperature Measurement
• 10.4 NIR
• 10.5 Chord Length Determination (FBRM and SFV)
• 10.6 The Lighthouse Probe
• 10.7 Image analysis
• 10.8 Other methods
• 10.9 Summary
• References

Chapter 11. Process Scale-Up

• Abstract
• 11.1 Introduction
• 11.2 Various Scale-Up Considerations and Approaches
• 11.3 Scale-Up of Fluid Bed Granulation and Drying
• 11.4 Case Studies—Granulation Scale-Up
• 11.5 Fluid Bed Coating Scale-Up
• 11.6 Rotary Fluid Bed Coating
• 11.7 Summary
• References

Chapter 12. Integrated Systems

• Abstract
• 12.1 Material Handling
• 12.2 Integrated Systems for Nonpotent Compounds
• 12.3 Integrated Systems for Potent Compounds
• 12.4 Summary
• Reference

Chapter 13. Process Troubleshooting

• Abstract
• 13.1 Troubleshooting the Granulation Process
• 13.2 Troubleshooting the Drying Process
• 13.3 Troubleshooting the Coating Process
• 13.4 Summary
• References

Chapter 14. Fluid Bed Safety

• Abstract
• 14.1 Introduction
• 14.2 Safety From Solvents
• References