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Elsevier

Histopathology Atlas of Acute Radiation Syndrome and Delayed Effects in Rhesus Macaques

Kidney, Lung, Heart, Intestine and Mesenteric Lymph Node

  • 1st Edition - August 3, 2022
  • Latest edition
  • Author: George Parker
  • Language: English

Histopathology Atlas of Acute Radiation Syndrome and Delayed Effects in Rhesus Macaques: Kidney, Lung, Heart, Intestine and Mesenteric Lymph Node provides a thoroughly illustrat… Read more

Description

Histopathology Atlas of Acute Radiation Syndrome and Delayed Effects in Rhesus Macaques: Kidney, Lung, Heart, Intestine and Mesenteric Lymph Node provides a thoroughly illustrated review of the tissue damage and reparative changes associated with standardized irradiation doses in rhesus macaques. In addition to time-sequenced, routinely stained histologic sections, the book presents results of numerous histochemical, immunohistochemical and chromogenic in-situ stains that provide insights into the pathogenesis of radiation-associated tissue injury and repair. This book is compiled and written by a board-certified veterinary pathologist with more than 40 years of experience in the interpretation of experimentally induced tissue alterations in laboratory animals.

This is an important resource for researchers in the field of animal science radiation injury, including radiation oncologists and individuals involved in disaster preparedness related to accidental or deliberate radiation exposure in large populations.

Key features

  • Addresses the chronological sequence of tissue alterations following defined radiation doses in rhesus macaques
  • Provides photo-documentation of a broad range of histochemical and immunohistochemical stains that illustrate tissue damage and reparative changes following irradiation
  • Presents insights into the involvement of various signaling and effector molecules in the development of radiation-associated injury

Readership

Researchers in nonhuman primate radiation (animal science and animal oncology). Radiation oncologists seeking translatable research for humans

Table of contents

Chapter 1: Kidney
Routine histology stain-
Hematoxylin & eosin
Histochemical stains-
Periodic acid-Schiff/hematoxylin
Phosphotungstic acid/hematoxylin
Chromotrope-aniline blue
Masson’s trichrome
Immunohistochemical stains-
von Willebrand factor
Collagen 1
Alpha smooth muscle actin
Connective tissue growth factor
CD3
CD20
CD31
CD38
CD68
CD163
Myeloperoxidase
Tryptase
Galectin-3
Pro-renin receptor

Chapter 2: Lung
Routine histology stain-
Hematoxylin & eosin
Histochemical stains-
Masson’s trichrome
Toluidine blue
Immunohistochemical stains-
Collagen 1
Alpha smooth muscle actin
Connective tissue growth factor
CD31
CD163
CD206
Myeloperoxidase
Tryptase
Galectin-3
Transforming growth factor-beta
Caspase 3

Chapter 3: Heart
Routine histology stain-
Hematoxylin & eosin
Histochemical stains-
Masson’s trichrome
Immunohistochemical stains-
Caspase 3
Galectin-3
Alpha smooth muscle actin

Chapter 4: Jejunum
Routine histology stain-
Hematoxylin & eosin
Histochemical stains-
Masson’s trichrome
Alcian blue/periodic acid-Schiff
Immunohistochemical stains-
MxA
Ki67
Connective tissue growth factor
Collagen 1
CD13
CD163
Lipopolysaccharide

Chapter 5: Colon
Routine histology stain-
Hematoxylin & eosin
Histochemical stains-
Masson’s trichrome
Alcian blue/periodic acid-Schiff
Immunohistochemical stains
Ki67
Collagen 1
Connective tissue growth factor
CD163
Lipopolysaccharide

Chapter 6: Mesenteric lymph node
Routine histology stain-
Hematoxylin & eosin
Histochemical stains-
Masson’s trichrome
Immunohistochemical stains-
Collagen 1
Myeloperoxidase
MxA
Lipopolysaccharide
Transforming growth factor-beta
Tryptase
CD163

Review quotes

*4 stars* "...a detailed morphologic description of radiation-induced injury in selected tissues of rhesus macaques. The text is highly illustrated with histopathologic images of both conventional and special stained sections as well as immunohistochemistry,...providing a database in support of future studies that account for the 3Rs (reduce, refine, and replace) in the use of research animals…. [for] researchers in the field of radiation injury, including radiation oncologists and individuals involved in disaster preparedness related to radiation exposure… [and] the wider pathology and research community…. [A] unique publication that includes a detailed histopathology database in a pivotal animal model."—©Doody’s Review Service, 2023, Wanda Haschek-Hock, BVSc, PhD (University of Illinois College of Veterinary Medicine)

Product details

  • Edition: 1
  • Latest edition
  • Published: August 3, 2022
  • Language: English

About the author

GP

George Parker

Dr. George Parker currently serves as Senior Scientific Director, Global Pathology, at Charles River Laboratories. He received the Doctor of Veterinary Medicine (DVM) degree from the Auburn University College of Veterinary Medicine, completed a veterinary pathology residency at the Armed Forces Institute of Pathology, and received a PhD degree in immunology from Rutgers University. He is a diplomate of the American College of Veterinary Pathologists as well as the American Board of Toxicology, and a Fellow of the International Academy of Toxicologic Pathology. He has more than 30 years of experience as a toxicologic pathologist and has served as study pathologist on several hundred drug and chemical safety studies. He has published numerous book chapters and peer-reviewed journal articles that have been focused primarily on toxicologic pathology.
Affiliations and expertise
Senior Scientific Director, Global Pathology, Charles River Laboratories, Durham, NC, USA

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