High-LET Radiations in Clinical Radiotherapy

Proceedings of the 3rd Meeting on Fundamental and Practical Aspects of the Application of Fast Neutrons and Other High-LET Particles in Clinical Radiotherapy, The Hague, Netherlands, 13—15 September 1978

1st Edition - January 1, 1979

Editors: G. W. Barendsen, J. J. Broerse, K. Breur

eBook ISBN:

9 7 8 - 1 - 4 8 3 1 - 8 9 0 8 - 6

High-LET Radiations in Clinical Radiotherapy covers the proceedings of the 3rd Meeting on Fundamental and Practical Aspects of the Application of Fast Neutrons and other High-LET… Read more

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High-LET Radiations in Clinical Radiotherapy covers the proceedings of the 3rd Meeting on Fundamental and Practical Aspects of the Application of Fast Neutrons and other High-LET Particles in Clinical Radiotherapy. The title presents papers that report the experiences in utilizing High-LET radiations in clinical radiotherapy. The coverage of the text includes observations on the reactions of normal and malignant tissues to a standard dose; and clinical observations of early and late normal tissue injury and tumor control in patients receiving fast neutron irradiation. The selection also covers results of fast neutron radiotherapy at Amsterdam; and results of clinical applications with fast neutrons in Edinburgh. The book will be of great use to students and practitioners of medical technology.

Introduction to the Proceedings

Sessions I and II. Reports on Clinical Experience

Second Preliminary Report of the M. D. Anderson Study of Neutron Therapy for Locally Advanced Gynecological Tumors

Observations on the Reactions of Normal and Malignant Tissues to a Standard Dose of Neutrons

Results of Fast Neutron Radiotherapy at Amsterdam

Results of Fast Neutron Beam Radiotherapy Pilot Studies at the University of Washington

Results of Clinical Applications with Fast Neutrons in Edinburgh

Fast Neutron Project at Fermilab

Clinical Observations of Early and Late Normal Tissue Injury and Tumor Control in Patients Receiving Fast Neutron Irradiation

Results of Clinical Applications of Fast Neutrons at Hamburg-Eppendorf

Results of Clinical Applications of Negative Pions at Los Alamos

Results of Tumor Treatments with Alpha Particles and Heavy Ions at Lawrence Berkeley Laboratory

Results of Clinical Applications of Fast Neutrons in Japan

Five Years of Clinical Experience with a Combination of Neutrons and Photons

Hyperbaric Oxygen and Hypoxic Cell Sensitizers in Clinical Radiotherapy: Present State and Prospects

Treatment at Low Dose Rate, by Low-LET Radiation: Present Status and Prospects

Combined Chemo/Radiotherapy of Cancer: Present State and Prospects for Use with High-LET Radiotherapy

Sessions III and IV. Physical Aspects and Radiobiology

Review of Performance of High-LET Radiation Sources Used in Clinical Applications

Dose Distributions of Clinical Fast Neutron Beams

Dosimetry Intercomparisons and Protocols for Therapeutic Applications of Fast Neutron Beams

Characteristics of Fast Neutron Sources

Contributions on Characteristics of Fast Neutron Sources

Neutron Dosimetry, Radiation Quality and Biological Dosimetry

Contributions on Neutron Dosimetry, Radiation Quality and Biological Dosimetry

Review of RBE Data for Cells in Culture

RBE Values of Fast Neutrons for Responses of Experimental Tumors

Neutron RBE for Normal Tissues

Fast Neutron Radiobiology

Contributions on fast Neutron Radiobiology

Dosimetry and Radiobiology of Negative Pions and Heavy Ions

Contributions on Dosimetry and Radiobiology of Negative Pions and Deavy Ions

The Committee on Radiation Oncology Studies Plan for a Program in Particle Therapy in the United States

Sessions V and VI. Evaluation of Present Results and Future of High LET Radiotherapy

Evaluation of Clinical Experience Concerning Evaluation of Tumor Response to High-LET Radiation

Evaluation of Normal Tissue Responses to High-LET Radiations

The Application of RBE Values to Clinical Trials of High-LET Radiations

Doses and Fractionation Schemes to Be Employed in Clinical Trials of High-LET Radiations

Review of Protocols for High-LET Radiotherapy in the United States

Clinical Trials with Fast Neutrons in Europe

Summary of Discussion on Multi-Center Collaboration in Clinical Trials with High-LET Radiations

Concluding Remarks on the Future of High-LET Radiotherapy

List of Participants of the 3rd Meeting on Fundamental and Practical Aspects of the Application of Fast Neutrons and Other High-LET Particles in Clinical Radiotherapy