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Hemophilia and Von Willebrand Disease

Factor VIII and Von Willebrand Factor

  • 1st Edition - June 14, 2018
  • Latest edition
  • Author: David Green
  • Language: English

Hemophilia and Von Willebrand Disease: Factor VIII and Von Willebrand Factor serves as a must-have reference on the important role these essential blood-clotting proteins play in r… Read more

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Description

Hemophilia and Von Willebrand Disease: Factor VIII and Von Willebrand Factor serves as a must-have reference on the important role these essential blood-clotting proteins play in research and clinical medicine. Clinicians and researchers face the daily challenge of staying current on the vast amounts of research that is now generated. The reference to Janus in the title refers to the two roles of the Factor VIII/Von Willebrand Factor Complex: initiation of coagulation and propagation of clot formation. The complex prevents bleeding in hemophilia and Von Willebrand disease but also augments arterial and venous thrombosis.

Key features

  • Presents one source of information on Hemophilia and Von Willebrand Disease, as well as Factor VIII and Von Willebrand Factor, eliminating the search through hundreds of journal articles
  • Combines the multi-disciplinary research that is generated from Factor VIII/Von Willebrand Factor – hematology, drug discovery, genetics, cell biology, and oncology
  • Delves into unanswered questions and future directions of this important blood-clotting complex

Readership

Residents, fellows and professionals in hematology, genetics, cell biology, oncology, and drug discovery

Table of contents

1. Historical Background2. Factor VIII: Anatomy and PhysiologyA. Isolation & Relationship to the Von Willebrand FactorB. StructureC. Cell of Origin, Secretion, & ClearanceD. Participation in Hemostasis & Inactivation

3. Genetic Basis of HemophiliaA. Factor VIII geneB. MutationsC. Hemophilia in WomenD. Carrier Detection & Prenatal Diagnosis

4. Factor VIII Therapy for BleedingA. Plasma and CryoprecipitateB. Recombinant Factor VIIIC. Gene Therapy

5. Complications of TherapyA. Allergic ReactionsB. ThrombosisC. Alloantibodies

6. Acquired Disorders of Factor VIIIA. AutoantibodiesB. Non-immunologic

7. Factor VIII and ThrombosisA. Genetic disordersB. HormonesC. Role in ThrombosisD. Antithrombotic Therapy

8. Factor VIII: Future DirectionsA. Re-engineering FVIII for oral or topical administrationB. Decreasing FVIII immunogenicityC. Anti-thrombotics that block FVIII D. Genetic and cell-based approaches

Product details

  • Edition: 1
  • Latest edition
  • Published: June 14, 2018
  • Language: English

About the author

DG

David Green

David Green, MD, PhD, is Professor Emeritus in Medicine, Division of Hematology/Oncology, at Northwestern University Feinberg School of Medicine in Chicago, Illinois. He received his medical degree from Jefferson Medical College in Philadelphia, Pennsylvania and Doctorate in Biochemistry from Northwestern University, Evanston, Illinois. He is a clinician-investigator and author of more than 300 published scientific articles. His most recent book, Linked by Blood: Hemophilia and AIDS, describes the AIDS epidemic in the early 1980s that ravaged the hemophilia community and led to major changes in the collection and processing of blood and blood products. He is a Master of American College of Physicians and recipient of many other awards.
Affiliations and expertise
Professor of Medicine Emeritus, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

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