Hematopoiesis
- 1st Edition, Volume 118 - April 29, 2016
- Latest edition
- Editor: Emery Bresnick
- Language: English
Hematopoiesis, the latest volume in the Current Topics in Developmental Biology, covers hematopoiesis, with contributions from an international board of authors. Its chapters pro… Read more
Hematopoiesis, the latest volume in the Current Topics in Developmental Biology, covers hematopoiesis, with contributions from an international board of authors. Its chapters provide a comprehensive set of reviews covering such topics as the regulation of blood stem cell development, epigenetic mechanisms controlling erythropoiesis, and regulatory RNAs/HSCs.
- Covers the area of hematopoiesis
- International board of authors
- Provides a comprehensive set of reviews covering such topics as regulation of blood stem cell development, epigenetic mechanisms controlling erythropoiesis, and regulatory RNAs/HSCs
Researchers in cell, developmental and molecular biology and in genetics.
- Preface
- Chapter One: Regulation of Blood Stem Cell Development
- Abstract
- 1 Introduction
- Chapter Two: Hematopoietic Stem Cell and Its Bone Marrow Niche
- Abstract
- 1 Introduction
- 2 Evolution of the Stem Cell Niche Concept
- 3 Location Matters
- 4 Cellular Participants in the Bone Marrow Microenvironment
- 5 The Sympathetic Nervous System
- 6 HSC Mobilization from the BM Niche
- 7 Niche of Hematopoietic Malignancies
- 8 Perspectives
- Chapter Three: The Hematopoietic Stem and Progenitor Cell Cistrome: GATA Factor-Dependent cis-Regulatory Mechanisms
- Abstract
- 1 cis-Regulatory Mechanisms
- 2 GATA Factor Interactions with DNA and Chromatin
- 3 Components of Scl/TAL1 and GATA Factor Complexes at E-box–GATA Elements
- 4 HSPC Cistrome
- 5 Perspective
- Chapter Four: ETS Transcription Factor ETV2/ER71/Etsrp in Hematopoietic and Vascular Development
- Abstract
- 1 Introduction
- 2 Etv2 Is Transiently Expressed in the Hemangiogenic Progenitors
- 3 ETV2 Is Sufficient to Induce Hematopoietic and Endothelial Cell Formation
- 4 Nonredundant and Transient Role of ETV2 in Hematopoietic and Endothelial Cell Formation
- 5 ETV2, VEGF, and FLK1 in Hematopoietic and Endothelial Cell Formation
- 6 ETV2 Regulates Hemangiogenic versus Cardiac Mesoderm Outcome
- 7 ETS Hierarchy and ETS Switching Mechanisms in Hematopoietic and Vascular Development
- 8 ETV2 in Definitive Hematopoietic Program and Function
- 9 Regulation of Etv2 Expression
- 10 Closing Thoughts and Future Directions
- Acknowledgments
- Chapter Five: Taking the Leap: Runx1 in the Formation of Blood from Endothelium
- Abstract
- 1 The Three Waves of Blood Cell Formation
- 2 The Role of Runx1 in the Formation of Embryonic Progenitors and HSCs
- 3 The Temporal Requirement for Runx1 in Hemogenic Endothelium
- 4 Downstream Runx1 Targets That Execute the Endothelial to Hematopoietic Cell Transition
- 5 Epigenetic Regulation by Runx1
- 6 Cis-Acting Sequences Regulating Runx1 Transcription
- 7 The Gene Regulatory Network Upstream of Runx1
- 8 Signaling Pathways Regulating Runx1 Expression in the Aorta
- 9 Conclusions and Future Directions
- Chapter Six: SCL/TAL1 in Hematopoiesis and Cellular Reprogramming
- Abstract
- 1 Introduction
- 2 SCL Function During Development
- 3 The Long, the Intermediate, and the Short (Term): HSC Function and Scl
- 4 The SCL Complex
- 5 SCL and Cellular Reprogramming
- 6 Concluding Remarks
- Acknowledgments
- Chapter Seven: Navigating Transcriptional Coregulator Ensembles to Establish Genetic Networks: A GATA Factor Perspective
- Abstract
- 1 Introduction
- 2 The GATA Factor Coregulator Repertoire
- 3 GATA Factor Posttranslational Modifications
- 4 Transcription Factor Cooperation
- 5 Assembling and Deciphering a Coregulator Matrix Governing GATA Factor Function
- Chapter Eight: Noncoding Regulatory RNAs in Hematopoiesis
- Abstract
- 1 Introduction
- 2 Emerging Importance of Regulatory RNAs in Hematopoiesis
- 3 Regulatory RNAs in Normal Hematopoiesis
- 4 ncRNAs in Hematopoietic Malignancies
- 5 ncRNAs as Biomarkers
- 6 LncRNA Databases
- 7 Conclusions
- Acknowledgments
- Index
Praise for the Series:
"Outstanding both in variety and in the quality of its contributions." —Nature
"Outstanding both in variety and in the quality of its contributions." —Nature
- Edition: 1
- Latest edition
- Volume: 118
- Published: April 29, 2016
- Language: English
EB
Emery Bresnick
Professor, Cell & Regenerative Biology, Director, UW Madison Blood Research Program, University of Wisconsin Madison, USA
Affiliations and expertise
Cell & Regenerative Biology, UW Madison Blood Research Program, University of Wisconsin Madison, USARead Hematopoiesis on ScienceDirect