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Hematology
A Pathophysiologic Approach (Mosby Physiology Series)
- 2nd Edition - June 12, 2023
- Author: S. David Hudnall
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 5 9 5 8 3 - 4
Gain a foundational understanding of complex hematology concepts with this thoroughly revised text. Hematology: A Pathophysiologic Approach, 2nd Edition, a volume in the Mosby… Read more
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Request a sales quoteGain a foundational understanding of complex hematology concepts with this thoroughly revised text. Hematology: A Pathophysiologic Approach, 2nd Edition, a volume in the Mosby Physiology Series, explains the fundamentals of this multi-faceted area in a clear and concise manner. It offers masterful explanations of hematopoiesis, immunology, hemostasis, hemoglobinopathy, metabolic disorders, genetics, and neoplasia from S. David Hudnall, MD, Professor Emeritus of Pathology and Laboratory Medicine at Yale University School of Medicine. Prof. Hudnall, who has practiced laboratory hematology and hematopathology for more than 30 years, has taught the principles of hematology to thousands of pre-medical undergraduates and medical students. Rich, clinically oriented coverage from cover to cover makes this text an ideal, problem-based way to learn about this complex subject.
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Offers an accessible yet thorough understanding of hematolymphoid physiology and pathophysiology, helping you easily master the material in a systems-based curriculum with learning objectives, Clinical Concept boxes, highlighted key words and concepts, chapter summaries, and end-of-chapter review questions.
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Clearly explains interrelationships between the diverse factors that can give rise to disease.
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Covers a wide range of subjects, including platelets and coagulation, transfusion medicine, cytotoxic chemotherapy, infections, the immune system, and bone marrow transplantation.
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Shows how hematologic disorders are evaluated through blood counting, histopathology, immunohistochemistry, cytogenetics, and coagulation testing.
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Features 150 full-color photomicrographs to help you visualize a wide spectrum of hematologic pathology.
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An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Medical students
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Preface
- Preface to the second edition
- Acknowledgments
- List of Illustrations
- List of Tables
- 1. Brief overview of the hematolymphoid system
- Key words and concepts
- 2. Hematopoiesis
- Technical considerations
- Key words and concepts
- 3. Erythropoiesis and oxygen transport
- Oxygen transport
- Key words and concepts
- 4. Iron, heme, and hemoglobin
- Iron uptake in the duodenum
- Iron storage and regulation: Hepatocytes
- Iron storage and recycling: Macrophages
- Iron-deficiency anemia
- Hemochromatosis
- Heme
- Porphyria
- Sideroblastic anemia
- Hemoglobin
- Hemoglobin oxygen affinity
- Key words and concepts
- 5. Hemoglobinopathy
- Nonfunctional hemoglobin variants
- Beta-globin mutations
- Thalassemia
- Unstable hemoglobin variants
- Key words and concepts
- 6. Red blood cell metabolism and enzyme defects
- Red blood cell enzyme defects
- Key words and concepts
- 7. Hemolytic anemia
- Extrinsic hemolytic anemia
- Intrinsic hemolytic anemia
- Key words and concepts
- 8. Aplastic anemia and related disorders
- Anemia secondary to nonhematopoietic disease
- Key words and concepts
- 9. Megaloblastic anemia
- Key words and concepts
- 10. Myeloid cells
- Neutrophils
- Eosinophils
- Basophils and mast cells
- Monocytes
- Key words and concepts
- 11. Immune system and related disorders
- T cells
- B cells
- Immunoglobulin structure and function
- Complement
- T-cell receptor signaling
- T-cell subsets
- Immunodeficiency
- Lymphoid tumors
- Key words and concepts
- 12. Genetic basis of hematologic neoplasia
- Cell proliferation
- Apoptosis
- Specific genetic defects in hematologic cancer
- Molecular and cytogenetic techniques
- Key words and concepts
- 13. Leukemia and related disorders
- Introduction
- Acute myeloid leukemia
- Acute lymphoblastic leukemia (precursor lymphoblastic leukemia)
- Chronic lymphocytic leukemia
- Myelodysplastic syndromes
- Myeloproliferative neoplasms
- Myelodysplastic/myeloproliferative diseases
- Key words and concepts
- 14. Lymphoma and related disorders
- B-cell non-hodgkin lymphoma
- T-cell and natural killer cell lymphoma
- Hodgkin lymphoma
- Classic hodgkin lymphoma
- Histiocytic and dendritic cell neoplasms
- Key words and concepts
- 15. Blood coagulation
- Blood coagulation
- Fibrinolysis
- Bleeding disorders
- Hereditary thrombophilia
- Anticoagulation
- Coagulation testing
- Key words and concepts
- 16. Platelets
- Thrombocytopenia and thrombocytosis
- Platelet function defects
- Key words and concepts
- 17. Benign conditions of lymphoid organs
- Spleen
- Thymus
- Key words and concepts
- 18. Blood transfusion and stem cell transplantation
- Blood transfusion
- Blood groups
- Transfusion reactions
- Stem cell transplantation
- Complications of allogeneic stem cell transplantation
- Human leukocyte antigens
- Key words and concepts
- 19. Hematologic cancer therapy
- Cell-cycle active agents
- Non–cell-cycle active agents
- Key words and concepts
- Appendix A. Answers to review questions
- Appendix B. Complete blood count
- Appendix C. Some useful immunophenotypic markers for hematologic diagnosis
- Index
- No. of pages: 240
- Language: English
- Edition: 2
- Published: June 12, 2023
- Imprint: Elsevier
- Paperback ISBN: 9780323595834
SH
S. David Hudnall
Affiliations and expertise
Professor of Pathology and Laboratory Medicine, Division Chief of Hematopathology, University of Texas Medical Branch, Galveston, TX