Hematological Insights and Clinical Implications of Platelet Functions in Lymphatic Filariasis

1. Introduction to lymphatic filariasis
Tuhina Banerjee and Shruti Kaushal
Introduction
History
Epidemiology
Causative agent
Host
Pathogenesis of lymphatic filariasis
Clinical presentations
Laboratory diagnosis
Treatment
Prevention and control
Conclusion
References


2. Global burden of lymphatic filariasis
Awadhesh Kumar Yadav
Introduction
Country‑wise burden of lymphatic filariasis
Lymphatic filariasis burden in other Asian countries
The efforts that have been made to control lymphatic filariasis over the past few decades and related potential concerns
Conclusion
References


3. Pathogenesis and hematological findings in lymphatic filariasis
Vikas Kailashiya
Introduction
Life cycle of the filarial parasite
Periodicity of microfilaremia
Transmission
Pathogenesis of clinical manifestations in lymphatic filariasis
Symbiosis with Wolbachia


4. Immunology related to chronic edema, inflammation, and their cardiovascular effects
Shruti Gupta
Introduction
Involvement of the immune system in chronic edema
Immunology related to chronic edema and inflammation
Lymphatic filariasis‑associated edema
Effects on cardiovascular system
Conclusion
References


5. Platelet biology and functions
Paresh P. Kulkarni
Introduction
Overview of platelets' role in clot formation or “hemostasis”
Platelet morphology
Platelet megakaryopoiesis
Platelet shape change, spreading, contraction, and clot retraction
Platelets, inflammation, and infection
Signaling pathways in stimulated platelets
Conclusion
All disclosure
Reference


6. Impact of lymphatic filariasis on platelet count and functions and their biochemical and molecular mechanisms
Jyotsna Kailashiya
Introduction
Platelet count
Platelet size
Platelet size distribution
Platelet aggregation
Platelet surface markers
Plasma markers of platelet functions
Clinical implications
Conclusion
References


7. Role of immunomodulation in the pathogenesis of filariasis
Anu Singh
Introduction
Immune system modulation by filarial parasites
Immunomodulation strategies of filarial parasite
Clinical implications
Conclusion
All disclosure
References


8. Prevention and therapeutic interventions of lymphatic filariasis
Abhijit Chaudhary and K.R. Subash
Introduction
Prevention of lymphatic filariasis
Therapeutic interventions for lymphatic filariasis
Conclusion
References


9. Future directions of research on platelet function in lymphatic filariasis
Vijay Kumar Sonkar and Debabrata Rout
Introduction
Future research prospects
Policy translation for future research on platelets in lymphatic filariasis
Conclusion
All disclosure
References