Heavy Particle Radiotherapy

ForewordAcknowledgmentsIntroductionChapter 1 Radiobiological Phenomena I Introduction II Oxygen Effect III Cell-Cycle Sensitivity IV Recovery from Damage ReferencesChapter 2 Biological Effects of High-LET Radiations I Introduction II Interaction of Heavy Particles with Tissue III Sources of High-LET Radiations IV Cell Survival for High-LET Radiations V OER vs LET VI RBE and OER for High- and Low-LET Radiations VII Cell-Cycle Sensitivity Variation vs LET VIII Recovery from Sublethal Injury Inflicted by Radiations of Different LET IX Recovery from Potentially Lethal Damage Inflicted by High-LET Radiations X Hypoxic Cell Sensitizers and High-LET Radiations ReferencesChapter 3 Neutrons I Introduction II Early Experiences with Fast Neutrons and Their Implications for Future Use of High-LET Radiations in Therapy III Fast Neutron Sources IV Physical Aspects of Fast Neutrons V Effects of Neutrons on Cultured Cells VI Effects of Neutrons on Normal Tissues VII Effects of Neutrons on Tumors VIII Neutron Dosimetry and Radiobiology Intercomparisons IX Current Neutron Radiotherapy X Neutron Capture Therapy XI Radiotherapy with Californium-252 ReferencesChapter 4 Protons I Introduction II Physical Aspects III Biological Effects IV Clinical Experiences with Protons ReferencesChapter 5 Helium Ions I Introduction II Physical Aspects III Biological Effects IV Clinical Experiences with Helium Ions ReferencesChapter 6 Heavy Ions I Introduction II Physical Aspects III Heavy Ion Radiobiology IV Clinical Studies with Heavy Ions ReferencesChapter 7 Negative Pions I Introduction II Physical Aspects III Biological Effects of Negative Pions IV Clinical Results ReferencesChapter 8 Comparison of Heavy Particles I Introduction II A Radiobiological Comparison of Heavy Particles ReferencesAppendix Radiobiological Techniques I Introduction II Mammalian Cell Survival Curves (In Vitro) III Mammalian Cell Survival Curves (In Vivo) IV Solid Tumors V Skin Reactions VI Late Reactions in Normal Tissues ReferencesIndex