Heat Shock Proteins in the Nervous System
- 1st Edition - July 13, 1994
- Latest edition
- Editors: Peter Jenner, R. J. Mayer, I. R. Brown
- Language: English
Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences.Cells respond to temper… Read more
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Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences.Cells respond to temperature elevation and other traumas by inducing a set of genes (cell stream genes) encoding cell stress (heat shock) proteins which may play important roles in cellular repair and/or protective mechanisms.This book surveys the current state of knowledge concerning the expression of heat shock genes and proteins in the nervous system following such traumatic events as hyperthermia, ischemia, and tissue wounding. The possible neuroprotective effects of the heat shock response are discussed. In addition to reviewing progress in animal model systems, this book discusses heat shock proteins such as ubiquitin in relation to human neurodegenerative diseases. Each chapter presents an overview of a specific subject area and includes current results from each authors laboratory and a viewpoint on future research directions.The book is organized in two parts: the first part deals with cell stress genes and their protein products; the second part deals with ubiquitin and the nervous system. The chapters are grouped so that each of the two sections begins with a description of the basic molecular cell biology of heat shock proteins or ubiquitin.Whether you are a new recruit to neuroscience or an established expert, look to this series for one-stop sources for the historical, physiological, pharmacological, biochemical, molecular biology and therapeutic aspects of your chosen research areas.
Research-level neuroscientists, pharmacologists, and neurologists from postgraduate to senior scientists in academia and industry.
L.E. Hightower and T. Li, Structure and Function of the Mammalian hsp70 Family.
I.R. Brown, Induction of Heat Shock Genes in the Mammalian Brain by Hyperthermia and Tissue Injury.
T.S. Nowak, Jr., S. Suga, and N.Saito, The Heat Shock Response and Gene Expression in Brain after Ischaemia.
M. Tytell, Heat Shock Proteins in the Retina and Optic Nerve.
B.E. Dwyer and R.N. Nishimura, Heat Shock Proteins and Neuroprotection in CNS Culture.
D. Walsh, K. Li, F. Zeng, L. Zhe, and M. Edwards, Heat Shock Genes and Cell Regulation in Early Mammalian Development.
A-P. Arrigo and P. Mehlen, Expression, Cellular Location and Function of Low Molecular Weight Heat Shock Proteins (hsp20s) during Development of the Nervous System.
M.E. Cheetham, J-P. Brion, and B.H. Anderton, Neuronal Homologues of the Bacterial Heat Shock Protein DnaJ.
K.D. Wilkinson, Cellular Roles of Ubiquitin.
D.W. Dickson and S-H.C. Yen, Ubiquitin, the Cytoskeleton and Neurodegenerative Diseases.
M. Landon, J. Lowe, and R.J. Mayer, Ubiquitin, Endosomes-Lysosomes and Neurodegenerative Diseases.
Subject Index.
I.R. Brown, Induction of Heat Shock Genes in the Mammalian Brain by Hyperthermia and Tissue Injury.
T.S. Nowak, Jr., S. Suga, and N.Saito, The Heat Shock Response and Gene Expression in Brain after Ischaemia.
M. Tytell, Heat Shock Proteins in the Retina and Optic Nerve.
B.E. Dwyer and R.N. Nishimura, Heat Shock Proteins and Neuroprotection in CNS Culture.
D. Walsh, K. Li, F. Zeng, L. Zhe, and M. Edwards, Heat Shock Genes and Cell Regulation in Early Mammalian Development.
A-P. Arrigo and P. Mehlen, Expression, Cellular Location and Function of Low Molecular Weight Heat Shock Proteins (hsp20s) during Development of the Nervous System.
M.E. Cheetham, J-P. Brion, and B.H. Anderton, Neuronal Homologues of the Bacterial Heat Shock Protein DnaJ.
K.D. Wilkinson, Cellular Roles of Ubiquitin.
D.W. Dickson and S-H.C. Yen, Ubiquitin, the Cytoskeleton and Neurodegenerative Diseases.
M. Landon, J. Lowe, and R.J. Mayer, Ubiquitin, Endosomes-Lysosomes and Neurodegenerative Diseases.
Subject Index.
- Edition: 1
- Latest edition
- Published: July 13, 1994
- Language: English
PJ
Peter Jenner
Professor Peter Jenner is a specialist in preclinical aspects of neurodegenerative diseases, notably Parkinson’s disease. He has spent the major part of his career at King’s College London where he was Head of Pharmacology for 14 years before returning to his research roots and subsequently becoming Emeritus Professor of Pharmacology. Peter has expertise in drug metabolism and pharmacokinetics but neuropharmacology based on functional models of neurodegenerative diseases has formed the major focus of his work. Peter holds a BPharm, PhD and DSc degree from the University of London. He has published well over 1000 articles with more than 700 peer reviewed papers. He is a Fellow of the Royal Pharmaceutical Society, the British Pharmacological Society, the Royal Society of Medicine and of King’s College London. Peter was recently honoured with a Doctor Honoris Causa degree from Carol Davila University of Medicine and Pharmacy, Bucharest and made an Honorary Fellow of The British Pharmacological Society for his contribution to research in to movement disorders.
Peter has worked closely with the pharmaceutical industry for many years and acts as an adviser and consultant to both major pharma and biotech companies. He has a wide knowledge of the drug discovery and drug development process and has been involved from molecule synthesis through to drug registration for use in man. Peter was the Founder, Director and Chief Scientific Officer of Proximagen, a biotech focussed on the treatment and cure of neurodegenerative diseases that was listed on AIMs and subsequently purchased by a US based healthcare company. He is a regular speaker at international meetings and also takes time to speak at Parkinson’s disease patient-carer groups across the UK.
Affiliations and expertise
Emeritus Professor of Pharmacology, Institute of Pharmaceutical Sciences, King’s College London, London, UKRM
R. J. Mayer
Affiliations and expertise
University of Nottingham, U.K.IB
I. R. Brown
Affiliations and expertise
University of Toronto, Scarborough Campus, West Hill, Ontario, Canada