Heart Development and Disease

1st Edition, Volume 156 - March 22, 2024
Editor: Nicole Dubois
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 2 9 7 - 2
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 2 9 8 - 9

Heart Development and Disease, Volume 156 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting c… Read more

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Heart Development and Disease, Volume 156 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters including Macrophages during heart valve development, Computational models of cardiovascular biology, Mechanisms of early sarcomere assembly, Role of RNA binding proteins during heart development and disease, Early heart development and morphogenesis, PSC models for development and disease, ECM or SHF development, Role of metabolism during heart development, Cellular ploidy in cardiac biology, and Genetics of CHD in the human population.

Cover image
Title page
Table of Contents
Series Page
Copyright
Contributors
Preface: Pushing the boundaries of cardiovascular research through interdisciplinary approaches, innovative thinking and new technologies
Chapter One: Macrophage lineages in heart development and regeneration
Abstract
1 Introduction
2 Macrophage lineage transitions in the developing heart
3 Contributions of macrophage lineages to cardiac organogenesis
4 Macrophages in cardiomyocyte maturation and heart regeneration after birth
5 Summary and conclusions
Acknowledgements
References
Chapter Two: Computational approaches for mechanobiology in cardiovascular development and diseases
Abstract
1 Introduction
2 Fundamental concepts in computational cardiovascular modeling
3 Computational modeling to investigate mechanobiology in cardiac development
4 Computational hemodynamic modeling for treatment planning in congenital heart
5 Computational predictive modeling of tissue growth and remodeling
6 Challenges and future opportunities
References
Chapter Three: RNA binding proteins in cardiovascular development and disease
Abstract
1 RNA binding proteins
2 Role of RBPs in mRNA life cycle
3 RNA binding protein-RNA complexes
4 RBPs in heart development
5 RBPs in congenital heart defects
6 Septation defects with RBP involvement
7 Outflow track/blood vessel/valve related congenital heart defects with RBP involvement
8 Other congenital heart defects with RBP involvement
9 Cardiomyopathy/heart failure with RBP involvement
10 Dilated cardiomyopathy
11 Complex congenital diseases with RBP involvement
12 RBPs in congenital heart diseases
13 RBFOX2/RBM9 and RBFOX1/A2BP1 (RNA binding Fox-1 homolog 1 & 2)
14 GATA4 (GATA binding protein 4)
15 DiGeorge syndrome critical region 8 (DGCR8)/Pasha
16 CPSF6: cleavage and polyadenylation specific factor 6 (CFlm68 or CPSF68)
17 NONO/ Non-POU domain containing octamer binding
18 RBM20/ RNA binding motif protein 20
19 RBM10/RNA binding motif protein 10
20 hnRNPA1/heterogeneous nuclear ribonucleoprotein A1
21 DDX3X/ DEAD-box helicase 3 X-linked
22 ADAR/adenosine deaminase RNA specific
23 hnRNPU/heterogeneous nuclear ribonucleoprotein U/scaffold attachment factor A (SAF-A)
24 PUF60/Poly(U) binding splicing factor 60
25 LRPPRC/leucine rich pentatricopeptide repeat containing/leucine-rich PPR motif-containing protein, mitochondrial
26 RBM8A (RNA binding motif protein 8A)
27 Ribosomal proteins
28 RPL3L/ribosomal protein L3 like
29 RBPs associated with congenital heart defects in animal models
30 QKI/quaking
31 PCBP1/poly(RC) binding protein1/ hnRNPE1/heterogeneous nuclear ribonucleoprotein E1
32 RBPs involved in heart development
33 Polypyrimidine tract binding protein 1
34 RNA binding motif protein 15
35 Concluding remarks
References
Chapter Four: Cardiac construction—Recent advances in morphological and transcriptional modeling of early heart development
Abstract
1 Introduction
2 Early heart development: specification, differentiation and assembly
3 Feel the beat: the intersection of form and function in the early heart
4 Stem cells, organoids, and cardioids: in vitro technologies to investigate early heart development
5 Challenges and future perspectives
Acknowledgments
References
Chapter Five: The cardiac conduction system: History, development, and disease
Abstract
1 Introduction
2 History of the CCS: Discovery and nomenclature
3 Development of the CCS: Key genes and transcriptional networks
4 Major diseases of CCS development
5 Concluding summary
References
Chapter Six: The role of metabolism in cardiac development
Abstract
1 Introduction
2 The metabolic environment during embryonic development
3 Metabolism as a source of energy and biomass
4 Metabolites as signaling molecules
5 Mitochondria
6 Conclusion
References
Chapter Seven: The genetics of cardiomyocyte polyploidy
Abstract
1 Introduction
2 Polyploidization mechanisms and timing
3 Speculated need for polyploidization
4 Methods for measuring polyploidy
5 Genes that impact cardiomyocyte ploidy
6 Ploidy and basal heart function or other non-injury phenotypes
7 Ploidy and injury response
8 Conclusions
Acknowledgements
References
Chapter Eight: Genetics and etiology of congenital heart disease
Abstract
1 Introduction: genetic etiologies of congenital heart disease
2 Aneuploidies
3 Structural variants
4 Single gene variants
5 Noncoding variants: common, rare, and de novo CHD risk
6 Conclusions
References

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Nicole Dubois