Handbook of Proteolytic Enzymes
Volume 5: Inhibitors of Proteolytic Enzymes
- 4th Edition - September 1, 2026
- Latest edition
- Editor: Neil D. Rawlings
- Language: English
The Handbook of Proteolytic Enzymes stands as the most comprehensive work in the field of applied enzymology and biocatalysis since the first edition published in 1998. Extensive… Read more
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The Handbook of Proteolytic Enzymes stands as the most comprehensive work in the field of applied enzymology and biocatalysis since the first edition published in 1998. Extensively revised and updated, the new, fourth edition is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. Edited by world-renowned experts in the field and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.
This volume offers a thorough discussion of known naturally-occurring and synthetic inhibitors of proteolytic enzymes. Each chapter includes enzyme inhibitor names, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with 2D and 3D structures of inhibitors in color, extensive references, and links to PubMed and MEROPS databases.
- The only comprehensive book on naturally-occurring and synthetic inhibitors of proteolytic enzymes
- Each chapter written by experts in their field, on proteolytic enzymes from all groups of living organisms and viruses, including those that are currently major targets of pharmaceutical research
- Fully searchable text, 2D and 3D structures of peptidases in color, and links directly to PubMed and MEROPS databases
- Details the latest proteotases used in therapeutic research, and discusses recent drug trials
Primary market/audience: Active researchers in biochemistry, medical chemistry, organic chemistry, molecular biology, cell biology, pharmacology; clinician scientists; researchers in industry and pharma
Secondary market/audience: Students of biochemical sciences; clinicians across disease specialties
1. Protein Inhibitors and Their Clans
2. Mechanisms of Inhibition
3. SPINK1
4. Aprotinin
5. Alpha-1-Peptidase Inhibitor
6. Antithrombin
7. Plasminogen Activator Inhibitor-1
8. C1 Inhibitor
9. SerpinA12
10. Sunflower Cyclic Trypsin Inhibitor
11. Elafin
12. Cystatin B
13. Cystatin C
14. Cystatin F
15. Phytocystatin
16. Timp-1
17. Timp-2
18. Alpha-2-Macroglobulin
19. SPINK5 Protein
20. Tissue Factor Pathway Inhibitor-1
21. Hepatocyte Growth Factor Activator Inhibitor Type 2
22. Secretory Leukocyte Peptidase Inhibitor
23. Calpastatin
24. Synthetic Inhibitors of Metallopeptidases
25. Synthetic Inhibitors of Cysteine Peptidases
26. Synthetic Inhibitors of Serine Peptidases
27. Synthetic Inhibitors of Other Peptidases
- Edition: 4
- Latest edition
- Published: September 1, 2026
- Language: English
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