Handbook of Proteolytic Enzymes, Two-Volume Set with CD-ROM
- 2nd Edition - May 27, 2004
- Editors: Alan J. Barrett, Neil D. Rawlings, J. Fred Woessner
- Language: English
Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecu… Read more
Description
Description
Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold.
Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing fully searchable text, specialised scissile bond searches, 3-D color structures and much more.
Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing fully searchable text, specialised scissile bond searches, 3-D color structures and much more.
Key features
Key features
- The only comprehensive book on proteolytic enzymes
- Includes 671 chapters, each written by experts in their field, on proteolytic enzymes from all groups of living organisms and the viruses, including those that are currently major targets of pharmaceutical research
- Accompanying CD-ROM provides fully searchable text, 2D structures of peptidases in color and links directly to PubMed and MEROPS databases
- Each chapter describes in detail the enzyme name, its history, activity and specificity, structural chemistry, preparation, biological aspects and distinguishing features
- Over 1000 peptidases included
Readership
Readership
Biochemists, Biotechnologists, Molecular and Cell Biologists, Biophysicists, Pharmaceutical Researchers, Biomedical Researchers, and Food Science Researchers
Table of contents
Table of contents
Sample of chapters listed according to catalytic type (chapter order will be reorganized by time of publication):
Aspartic Peptidases: Introduction: aspartic peptidases and their clans; Rous sarcoma virus retropepsin and avian myeloblastosis virus retropepsin; Pepsin F
Cysteine Peptidases: Introduction: the clans and families of cysteine peptidases; Coronavirus picornain-like cysteine proteinase; Calicivirus endopeptidases
Metallopeptidases: Introduction: metallopeptidases and their clans; Ophiolysin; Philodryas venom metalloproteinases
Serine Peptidases: Introduction: unsequenced serine peptidases; Muramoyl-pentapeptide carboxypeptidase; Tail-specific protease
Threonine Peptidases: Introduction: clan PB containing N-terminal nucleophile peptidases; HslVU protease; Glycosylasparaginase and other self-processing N-terminal nucleophile amidohydrolases
Unclassified Peptidases: Introduction: peptidases of unknown catalytic type; Murein tetrapeptide LD-carboxypeptidases; Tubulinyl-Tyr carboxypeptidase
Aspartic Peptidases: Introduction: aspartic peptidases and their clans; Rous sarcoma virus retropepsin and avian myeloblastosis virus retropepsin; Pepsin F
Cysteine Peptidases: Introduction: the clans and families of cysteine peptidases; Coronavirus picornain-like cysteine proteinase; Calicivirus endopeptidases
Metallopeptidases: Introduction: metallopeptidases and their clans; Ophiolysin; Philodryas venom metalloproteinases
Serine Peptidases: Introduction: unsequenced serine peptidases; Muramoyl-pentapeptide carboxypeptidase; Tail-specific protease
Threonine Peptidases: Introduction: clan PB containing N-terminal nucleophile peptidases; HslVU protease; Glycosylasparaginase and other self-processing N-terminal nucleophile amidohydrolases
Unclassified Peptidases: Introduction: peptidases of unknown catalytic type; Murein tetrapeptide LD-carboxypeptidases; Tubulinyl-Tyr carboxypeptidase
Review quotes
Review quotes
Praise for the second edition:
"The clear goal of these volumes is to provide complete coverage of proteases. All known enzymes of this class are described. As a reference, this is a very worthwhile contribution. The goals of this book are well met...The major strength of this book is the comprehensive coverage...An essential reference for scientific research...A very impressive offering…Any investigator with a protease question should start here."—Doody’s (2005)
"This handbook would be very useful a reference for a library that serves graduate and post-graduate researchers in molecular biology and related fields."—E-STREAMS (2005)
Doody's 4-star review-
“A very impressive offering. While many of the chapters are short, they provide essential information as well as appropriate references. Any investigator with a protease question should start here."—Eugene A. Davidson, PhD, Georgetown University School of Medicine in DOODYS
“The Handbook of Proteolytic Enzymes, second edition provides a structured and systematic, up-to-date account of the information about proteolytic enzymes...an indispensable reference for all researchers utilizing such enzymes in areas of organic chemistry, biochemistry, biotechnology and molecular biology."—John F. Kennedy and Menh M. He, Chembiotech Laboratories in CARBOHYDRATE POLYMERS, April 2005
“This handbook would be a very useful reference for a library that serves graduate and post-graduate researchers in molecular biology and related fields. However, the CD-ROM version may be significantly more useful than the print version, especially for workers adept with bioinformatics."—Rafael Garcia, Chemical Engineer USDA for E-STREAMS, March 2005
Praise for the first edition:
"The CD-ROM format is ideal for the presentation of this mass of structured information. There are a number of useful search facilities, including the unique Specificity Search procedure developed for this project.....Nethertheless with excellent diagrams, useful search facilities and extensive hyperlinks, the CD-ROM is far too useful a resource for any reader who is used to the vagaries of software to be put off by minor glitches...." —BIOCHEMICAL EDUCATION
"The Handbook of Proteolytic Enzymes is a much needed reference book in the field of peptidases. Not only does it provide a wealth of information for the vast majority of the individual enzymes discussed, but also it shows vividly the relationships among members of families and clans within the 4 major classes."—Michael N.G. James, MRC Canada, Group in Protein Structure and Function, Department of Biochemistry in PROTEIN SCIENCE
"...a massive and definitive compilation of information on proteolytic enzymes and will no doubt be the standard work for years to come...the information collected here will be of great value to scientists working in practically the whole of biology as well as to the biotechnology industry..."—BIOCHEMICAL EDUCATION
"The clear goal of these volumes is to provide complete coverage of proteases. All known enzymes of this class are described. As a reference, this is a very worthwhile contribution. The goals of this book are well met...The major strength of this book is the comprehensive coverage...An essential reference for scientific research...A very impressive offering…Any investigator with a protease question should start here."—Doody’s (2005)
"This handbook would be very useful a reference for a library that serves graduate and post-graduate researchers in molecular biology and related fields."—E-STREAMS (2005)
Doody's 4-star review-
“A very impressive offering. While many of the chapters are short, they provide essential information as well as appropriate references. Any investigator with a protease question should start here."—Eugene A. Davidson, PhD, Georgetown University School of Medicine in DOODYS
“The Handbook of Proteolytic Enzymes, second edition provides a structured and systematic, up-to-date account of the information about proteolytic enzymes...an indispensable reference for all researchers utilizing such enzymes in areas of organic chemistry, biochemistry, biotechnology and molecular biology."—John F. Kennedy and Menh M. He, Chembiotech Laboratories in CARBOHYDRATE POLYMERS, April 2005
“This handbook would be a very useful reference for a library that serves graduate and post-graduate researchers in molecular biology and related fields. However, the CD-ROM version may be significantly more useful than the print version, especially for workers adept with bioinformatics."—Rafael Garcia, Chemical Engineer USDA for E-STREAMS, March 2005
Praise for the first edition:
"The CD-ROM format is ideal for the presentation of this mass of structured information. There are a number of useful search facilities, including the unique Specificity Search procedure developed for this project.....Nethertheless with excellent diagrams, useful search facilities and extensive hyperlinks, the CD-ROM is far too useful a resource for any reader who is used to the vagaries of software to be put off by minor glitches...." —BIOCHEMICAL EDUCATION
"The Handbook of Proteolytic Enzymes is a much needed reference book in the field of peptidases. Not only does it provide a wealth of information for the vast majority of the individual enzymes discussed, but also it shows vividly the relationships among members of families and clans within the 4 major classes."—Michael N.G. James, MRC Canada, Group in Protein Structure and Function, Department of Biochemistry in PROTEIN SCIENCE
"...a massive and definitive compilation of information on proteolytic enzymes and will no doubt be the standard work for years to come...the information collected here will be of great value to scientists working in practically the whole of biology as well as to the biotechnology industry..."—BIOCHEMICAL EDUCATION
Product details
Product details
- Edition: 2
- Published: June 30, 2004
- Language: English
About the editors
About the editors
AB
Alan J. Barrett
Affiliations and expertise
Wellcome Trust Sanger Institute, Cambridge, U.K.NR
Neil D. Rawlings
Currently Dr. Neil Rawlings is a Senior Scientist in the Proteins Department at the EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. Dr. Rawlings has been an active researcher at the Wellcome Trust Sanger Institute for over twenty years. He is extremely well known in the proteolytic enzyme community for his work curating the MEROPS database, an information resource covering peptidases and the proteins that inhibit them, which is used by expert researchers and students worldwide. Dr. Rawlings has published widely in such peer reviewed journals as Genome Research, BMC Bioinformatics, PloS ONE, Nucleic Acids Research, the Journal of Biological Chemistry, and Science.
Affiliations and expertise
Senior Scientist, Proteins Department, EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UKJW
J. Fred Woessner
Affiliations and expertise
University of Miami, Florida, U.S.A.