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Handbook of Process Chromatography
Development, Manufacturing, Validation and Economics
- 2nd Edition - December 8, 2007
- Authors: Gunter Jagschies, Gail K. Sofer, Lars Hagel
- Language: English
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 5 5 4 5 1 - 8
This book will update the original edition published in 1997. Since the publication of the first edition, the biotechnology and biologics industries have gained extensive knowledge… Read more
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Request a sales quoteThis book will update the original edition published in 1997. Since the publication of the first edition, the biotechnology and biologics industries have gained extensive knowledge and experience in downstream processing using chromatography and other technologies associated with recovery and purification unit operations. This book will tie that experience together for the next generation of readers.
Updates include:
- sources and productivity
- types of products made today
- experiences in clinical and licensed products
- economics
- current status of validation
- illustrations and tables
- automated column packing
- automated systems
New topics include:
- the use of disposables
- multiproduct versus dedicated production
- design principles for chromatography media and filters
- ultrafiltration principles and optimization
- risk assessments
- characterization studies
- design space
- platform technologies
- process analytical technologies (PATs)
- biogenerics
- comparability assessments
Updates include:
- sources and productivity
- types of products made today
- experiences in clinical and licensed products
- economics
- current status of validation
- illustrations and tables
- automated column packing
- automated systems
New topics include:
- the use of disposables
- multiproduct versus dedicated production
- design principles for chromatography media and filters
- ultrafiltration principles and optimization
- risk assessments
- characterization studies
- design space
- platform technologies
- process analytical technologies (PATs)
- biogenerics
- comparability assessments
Key Features:- new approaches to process optimiaztion- use of patform technologies- applying risk assessment to process design
This book is suitable for practitioners, consultants and students in Biotechnology.
PrefaceAcknowledgements1. Biopharmaceuticals Today2. Process Capability and Production Scenarios3. Process Design Concepts4. Separation Technologies5. Analysis6. Cleaning and Sanitization7. Validation8. Economics9. Basic Properties of Peptides, Proteons, Nucleic Acids, and Virus Particles10. Optimization of Chromatographic Separations11. Equipment12. Column PackingAppendix A. Symbols and Definitions in Liquid ChromatographyAppendix B. Dimensionless NumbersAppendix C. Activities for Biopharmaceutical Production from Genetically Engineered Mammalian CellsAppendix D. Simulations Using the Supplied Software
- No. of pages: 382
- Language: English
- Edition: 2
- Published: December 8, 2007
- Imprint: Academic Press
- eBook ISBN: 9780080554518
GJ
Gunter Jagschies
Dr. Jagschies is a 30-plus year employee at GE Healthcare Life Sciences and a globally recognized expert in bioprocessing. He has published numerous papers and two books on the development, manufacturing and economics of biotherapeutics, and in 2012 he received the BioProcess International award “Thought Leader of the Decade”.
Affiliations and expertise
Strategic Customer Relations Leader, GE Healthcare, Freiburg im Breisgau, GermanyGS
Gail K. Sofer
Gail Sofer has been consulting with biotechnology and pharmaceutical companies for the past five years through the Fast Trak Validation(r) group of PharmaciaBiotech as the Director of International Validation Development. A series of publications on validation have provided guidance to many in this arena. She is active in organizations such as PDA and ASTM.
Affiliations and expertise
GE HealthcareLH
Lars Hagel
Lars Hagel is a Ph.D. in analytical chemistry and also Associate Professor at the University of Uppsala. Dr. Hagel has held different management positions within the R&D department and is now a senior scientific consultant of Pharmacia Biotech. He is a member of the board for The Swedish Centre for Bioseparations, and he chairs the Centre for Bioprocess Technology. Dr. Hagel's research has focused upon practical implications of chromatography theory and he has published a vast number of papers and chapters, with special reference to gel filtration.
Affiliations and expertise
Pharmacia Biotech AB