Handbook of Polymers in Medicine
- 1st Edition - August 23, 2023
- Editors: Masoud Mozafari, Narendra Pal Singh Chauhan
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 3 7 9 7 - 7
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 3 7 9 8 - 4
Handbook of Polymers in Medicine combines core concepts and advanced research on polymers, providing a better understanding of this class of materials in medicine. The book cove… Read more
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Request a sales quoteHandbook of Polymers in Medicine combines core concepts and advanced research on polymers, providing a better understanding of this class of materials in medicine. The book covers all aspects of medical polymers from characteristics and biocompatibility, to the diverse array of applications in medicine. Chapters cover an introduction to polymers in medicine and the challenges associated with biocompatibility in human tissue, polyurethane and supramolecular polymers and their specific applications in medicine, from tissue regeneration to orthopedic surgery and cancer therapeutics.
This book offers an interdisciplinary approach that will appeal to researchers in a range of disciplines, including biomedical engineering, materials science, chemistry, pharmacology and translational medicine. The book will also make a useful reference for clinicians and those in medical fields who are interested in materials for medical applications, as well as R&D groups involved in medical device design.
- Systematically covers individual polymer classes, from characteristics and biocompatibility to applications in biomedicine
- Covers a broad range of applications in medicine, such as cardiac tissue engineering, targeted drug delivery, dentistry, and more
- Provides an interdisciplinary review of polymers in medicine, allowing advanced students and experienced researchers in a range of biomedical and clinical fields to learn more about this fast-evolving area
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- 1. Natural and synthetic polymers in medicine
- Abstract
- 1.1 Introduction
- 1.2 Natural polymers and polymers derived from natural resources
- 1.3 Synthetic polymers used in medicine
- 1.4 Polymers in nanomedicine
- 1.5 Conclusion
- References
- 2. Cellular interactions and molecular signaling at the interface of cells and polymeric biomaterials
- Abstract
- 2.1 Introduction
- 2.2 Cells involved in the immune response
- 2.3 Cell biomaterials interactions
- 2.4 What influences cell behavior?
- 2.5 Methods for improving biocompatibility
- 2.6 Conclusion
- References
- 3. Protein adsorption on polymeric surfaces
- Abstract
- 3.1 Introdution
- 3.2 Fundamentals
- 3.3 Interaction between polymer and protein
- 3.4 Methods for analysis of protein interaction
- 3.5 Applications and advances
- 3.6 Conclusion
- References
- 4. Biocompatibility of polymers
- Abstract
- 4.1 Introduction
- 4.2 Biocompatibility
- 4.3 Biocompatible polymers
- 4.4 Applications of biocompatible polymers
- 4.5 Conclusions
- References
- 5. Hemocompatible polymers for medical applications
- Abstract
- 5.1 Introduction
- 5.2 Hemocompatibility of biomaterials
- 5.3 Hemocompatible polymeric surfaces
- 5.4 Polymers in blood-contacting applications
- 5.5 Conclusion
- References
- 6. Nanostructured polymeric materials for medicine
- Abstract
- 6.1 Introduction
- 6.2 Fabrication of nanostructured polymeric materials
- 6.3 Characterization of nanostructured polymeric materials
- 6.4 Properties of nanostructured polymer materials
- 6.5 Application of nanostructured polymeric materials
- 6.6 Biocompatibility and safety issues
- 6.7 Conclusions and future challenges
- References
- 7. Poly(ethylene glycol) based biomaterials
- Abstract
- 7.1 Introduction
- 7.2 Physical and chemical properties of poly (ethylene glycol)
- 7.3 Synthesis of PEG
- 7.4 Blending of PEG
- 7.5 PEGylation
- 7.6 The first-generation PEG chemistry
- 7.7 Second-generation PEG chemistry
- 7.8 Applications of polyethylene glycol as biomaterial
- 7.9 Polyethylene glycol in tissue engineering
- 7.10 Polyethylene glycol in drug delivery systems
- 7.11 Passive targeting
- 7.12 Active targeting
- 7.13 Other medical applications
- 7.14 Conclusion
- References
- 8. Polyurethane as biomaterials for biomedical applications
- Abstract
- 8.1 Introduction
- 8.2 Chemical structure of polyurethanes
- 8.3 Biomedical applications
- 8.4 Conclusion
- References
- 9. Polymer–protein conjugates as therapeutic
- Abstract
- 9.1 Introduction
- 9.2 Protein–polymer conjugate synthesis methods
- 9.3 Clinical applications
- 9.4 Treatment of various diseases
- 9.5 Biotechnology
- 9.6 Protein purification and separation
- 9.7 Conclusion
- References
- 10. Oxazoline and caprolactone based polymeric materials
- Abstract
- 10.1 Introduction
- 10.2 Oxazoline-based polymers for biomedical applications
- 10.3 Caprolactone-based polymers for biomedical applications
- 10.4 Oxazoline and caprolactone-based composite materials
- 10.5 Conclusion
- References
- 11. Conductive polymers for medical applications
- Abstract
- 11.1 History of conductive polymers
- 11.2 Conduction mechanism
- 11.3 Conductive polymers and their composites
- 11.4 Medical applications of conductive polymers
- 11.5 Future prospective of conductive polymers in medical applications
- 11.6 Conclusion
- References
- 12. Biodegradable/bioresorbable polymers for medical applications
- Abstract
- 12.1 Introduction to biodegradable polymers
- 12.2 Degradation of biopolymer
- 12.3 Classification of biodegradable polymers
- 12.4 Biodegradation test methods
- 12.5 Applications of biodegradable polymers in medicine
- 12.6 Conclusions
- References
- 13. Bioresorbable polymers for medical applications
- Abstract
- 13.1 Introduction to bioresorbable polymers
- 13.2 Bioresorption and bioresorbable polymers
- 13.3 Processing of bioresorbable polymers for medical applications
- 13.4 Conventional processing methods
- 13.5 Medical applications
- 13.6 Conclusion
- Refrences
- 14. Stimuli-responsive polymers for biomedical applications
- Abstract
- 14.1 Introduction
- 14.2 Endogenous stimuli-responsive polymers
- 14.3 pH-responsive polymers
- 14.4 Redox-responsive polymers
- 14.5 Ion-responsive polymers
- 14.6 Enzyme-responsive polymers
- 14.7 Glucose-responsive polymers
- 14.8 Exogenous stimuli-responsive polymers
- 14.9 Temperature-responsive polymers
- 14.10 Photo/Light-responsive polymers
- 14.11 Magnetic-responsive polymers
- 14.12 Electrical-responsive polymers
- 14.13 Ultrasound-responsive polymers
- 14.14 Conclusion
- References
- 15. Polycaprolactone as biomaterial
- Abstract
- 15.1 Introduction
- 15.2 Basic synthesis methods of polycaprolactone
- 15.3 Recent developments in PCL-based materials and their application
- 15.4 Conclusion
- References
- 16. Silicon-based polymers for biomedical application
- Abstract
- 16.1 Silicones
- 16.2 Composition
- 16.3 Structure
- 16.4 Properties
- 16.5 Biomedical applications
- 16.6 Interaction of silicone biomaterial with host tissue
- 16.7 Antimicrobial approaches of silicone biomaterial
- 16.8 Conclusion
- References
- 17. Polymers in tissue engineering and regenerative medicine
- Abstract
- 17.1 Introduction
- 17.2 Natural polymers in regenerative medicine and tissue engineering
- 17.3 Synthetic polymers applied in regenerative medicine and tissue engineering
- 17.4 Conclusion
- References
- 18. Polymers in wound repair and skin regeneration
- Abstract
- 18.1 Introduction
- 18.2 Polymeric biomaterials in wound-healing
- 18.3 Conclusion and future prespectives
- References
- 19. Polymers in bone and orthopedic surgery
- Abstract
- Abbreviations
- 19.1 Introduction
- 19.2 Polymers
- 19.3 Biodegradable polymers
- 19.4 Polymers used in bone and orthopedic surgery
- 19.5 Applications of polymers in bone and orthopedic surgery
- 19.6 Conclusion
- Acknowledgment
- References
- 20. Emerging polymers in dentistry
- Abstract
- 20.1 Introduction
- 20.2 Tooth structure and natural polymers in the tooth
- 20.3 Polymers used in dentistry applications
- 20.4 Polymers in dentistry
- 20.5 Novel developments
- 20.6 Conclusion
- References
- 21. Polymers in cancer research and clinical oncology
- Abstract
- 21.1 Introduction
- 21.2 Conducting polymers
- 21.3 Biodegradable polymers
- 21.4 Determination and treatment of cancer using conducting and biodegradable polymers
- 21.5 Conclusion
- Acknowledgment
- References
- 22. Polymers in drug delivery and targeting
- Abstract
- 22.1 Introduction
- 22.2 Biodegradable polymers and their types
- 22.3 Biodegradable polymers in targeted drug delivery
- 22.4 Future perspectives
- 22.5 Conclusions
- References
- 23. Polymer-based biosensors for medical applications
- Abstract
- Abbreviations
- 23.1 Introduction
- 23.2 Biosensors
- 23.3 Working principle of biosensors
- 23.4 Conducting polymer-based biosensors
- 23.5 PANI-based sensors
- 23.6 PPY-based sensors
- 23.7 PTH-based sensors
- 23.8 PEDOT-based sensors
- 23.9 Other CP-based sensors
- 23.10 Conclusion
- Acknowledgment
- References
- 24. Processing and characterization of polymeric biomaterials
- Abstract
- 24.1 Introduction
- 24.2 Processing techniques of polymeric biomaterials
- 24.3 Injection molding
- 24.4 Suitable thermal management and motion accuracy
- 24.5 Spinning techniques
- 24.6 Air-jet spinning
- 24.7 Additive manufacturing
- 24.8 Fused deposition modeling
- 24.9 Selective laser sintering/melting
- 24.10 Stereolithography
- 24.11 Binder jetting
- 24.12 Subtractive manufacturing
- 24.13 Leaching
- 24.14 Freeze drying
- 24.15 Characterization of polymeric biomaterials
- 24.16 Stress strain calculations
- 24.17 Impact test
- 24.18 Dynamic mechanical analysis
- 24.19 Thermal characterization of polymeric biomaterials
- 24.20 Differential scanning calorimetry
- 24.21 Differential scanning calorimetry
- 24.22 Differential thermal analysis
- 24.23 Thermomechanical analysis
- 24.24 Chemical characterization of polymeric biomaterials
- 24.25 Nuclear magnetic resonance spectroscopy
- 24.26 Nuclear magnetic resonance spectroscopy
- 24.27 X-ray diffraction
- 24.28 Energy dispersive x-ray spectroscopy
- 24.29 Biological characterization
- 24.30 In-vivo assays
- 24.31 Implantation
- 24.32 Biodegradation
- 24.33 In-vitro assays
- 24.34 Physical characterization
- 24.35 Mercury porosimetry
- 24.36 Mercury intrusion porosimetry
- 24.37 Gas adsorption
- 24.38 Brunauer, Emmett, and Teller
- 24.39 Zeta potential
- 24.40 Surface characterization of polymeric biomaterials
- 24.41 Microscopic analysis methods: SEM, TEM, AFM
- 24.42 Spectroscopic analysis methods
- 24.43 Other techniques
- 24.44 Microstructural characterization
- 24.45 Fourier transform infrared spectroscopy
- 24.46 Fourier transform infrared spectroscopy
- 24.47 Raman
- 24.48 Confocal laser spectroscopy microscopy
- 24.49 Wide and small angle x-ray scattering
- 24.50 Conclusion
- References
- 25. Regulations and standards for polymers in medicine
- Abstract
- 25.1 Introduction
- 25.2 Why regulations and standards are necessary?
- 25.3 Definitions
- 25.4 United States
- 25.5 European Union
- 25.6 Japan
- 25.7 Canada
- 25.8 Medical device definition by World Health Organization
- 25.9 Definition of “Medical Grade”
- 25.10 How materials earn the “medical grade” designation
- 25.11 Regulation for medical devices
- 25.12 Risk classification by region
- 25.13 United States
- 25.14 European Union
- 25.15 Japan
- 25.16 Others
- 25.17 Australia
- 25.18 Canada
- 25.19 New Zealand
- 25.20 Usage and their standards of polymers in medicine
- 25.21 Standards for polymeric materials used in medicine
- 25.22 ISO
- 25.23 USP
- 25.24 Systemic toxicity test
- 25.25 Intracutaneous (skin reaction) reactivity test
- 25.26 Implantation test
- 25.27 American society for testing and materials
- 25.28 What is the medical device regulation [MDR (EU) 2017/745]?
- 25.29 Why new regulation was necessary?
- 25.30 What changes will “the medical device regulation [MDR (EU) 2017/745]” bring?
- 25.31 Notified body
- 25.32 Detailed examination procedure
- 25.33 Clinical evaluation
- 25.34 Unique device identification
- 25.35 European database on medical devices
- 25.36 Notified bodies and the impact of Brexit
- 25.37 Conclusion
- References
- Index
- No. of pages: 800
- Language: English
- Edition: 1
- Published: August 23, 2023
- Imprint: Woodhead Publishing
- Paperback ISBN: 9780128237977
- eBook ISBN: 9780128237984
MM
Masoud Mozafari
NS