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Handbook of Machine Learning in Oncology

Foundations and Advanced Techniques

  • 1st Edition - June 1, 2027
  • Latest edition
  • Authors: Sanjay Saxena, Jasjit S. Suri
  • Language: English

Machine learning (ML) is transforming oncology by introducing innovative methodologies for early detection, diagnosis, treatment planning, and predicting patient outcomes.… Read more

Description

Machine learning (ML) is transforming oncology by introducing innovative methodologies for early detection, diagnosis, treatment planning, and predicting patient outcomes. Handbook of Machine Learning in Oncology: Foundations and Advanced Techniques provides a detailed guide for applying ML-based methods to cancer research and treatment. The first half of this comprehensive guide covers the basics of cancer biology and ML, including key concepts, algorithms, and data processing techniques. It presents the methodology for supervised and unsupervised learning, Deep Learning, radiomics, radiogenomics, and natural language processing, highlighting their importance in oncology. The second half of the book focuses on practical applications, offering detailed case studies on various cancers such as breast, lung, prostate, colorectal, brain, and pancreatic. This applied handbook discusses predictive modeling, diagnostic applications, treatment planning, and emerging technologies. The book offers a thorough and insightful exploration of how Machine Learning and Deep Learning are revolutionizing oncology, providing readers with the knowledge and tools to contribute to this rapidly evolving field.

Key features

  • Includes coverage of foundational concepts of Machine Learning and Deep Learning, as they relate to modelling and AI algorithms for imaging, diagnosis and predictive modeling in oncology
  • Provides in-depth technical coverage of machine learning techniques such as supervised and unsupervised learning, neural networks, reinforcement learning, support vector machines, and natural language processing
  • Presents crucial technologies and software platforms, along with advanced techniques such as radiomics, radiogenomics, and omics approaches
  • Provides in-depth technical coverage of diagnostic, prognostic, and classification, predictive, and treatment applications of Machine Learning across a range of cancer types and organ systems

Readership

Graduate students and researchers in the fields of bioinformatics, machine learning, biomedical engineering, and computer science, as well as researchers and academics interested in integrating machine learning into cancer research

Table of contents

Section 1: Introduction and Basics

1. Introduction to Machine Learning and Oncology

1.1. Overview of Cancer Biology

1.2. Historical Perspective on Cancer Treatment

1.3. Introduction to Machine Learning

1.4. Importance of Machine Learning in Oncology

1.5. Key Objectives and Structure of the Book

1.6. Overview of Machine Learning Algorithms

1.7. Integration of Machine Learning in Oncology Workflows

1.8. Current Challenges in Oncology and How ML Can Help

1.9. Case Studies Highlighting ML Impact in Oncology

1.10. Future Prospects of Machine Learning in Cancer Research


2. Fundamentals of Machine Learning

2.1. Introduction to Supervised Learning

2.2. Introduction to Unsupervised Learning

2.3. Introduction to Reinforcement Learning

2.4. Common Algorithms in Supervised Learning (SVM, Decision Trees, Neural Networks)

2.5. Common Algorithms in Unsupervised Learning (Clustering, Dimensionality Reduction)

2.6. Evaluation Metrics for ML Models

2.7. Model Validation Techniques

2.8. Feature Engineering and Selection

2.9. Overfitting and Underfitting

2.10. Practical Considerations in ML Model Development


3. Neuroscience Data Types

3.1. Types of Cancer Data: Genomic, Imaging, Clinical

3.2. Genomic Data: Collection, Annotation, and Processing

3.3. Imaging Data: MRI, CT, PET, and X-rays

3.4. Clinical Data: Electronic Health Records, Pathology Reports

3.5. Data Collection Methods

3.6. Data Annotation Techniques

3.7. Data Cleaning and Normalization

3.8. Feature Selection and Extraction

3.9. Data Integration from Multiple Sources

3.10. Challenges and Best Practices in Data Management

Section 2: Supervised and Unsupervised Learning

4. Supervised Learning Techniques

4.1. Introduction to Classification Algorithms

4.2. Support Vector Machines (SVM) in Oncology

4.3. Decision Trees and Random Forests

4.4. Neural Networks and Deep Learning for Cancer Diagnosis

4.5. Regression Models for Predictive Analysis

4.6. Case Studies: Predictive Modelling for Cancer Outcomes

4.7. Model Evaluation and Performance Metrics

4.8. Cross-Validation Techniques

4.9. Feature Importance and Model Interpretability

4.10. Practical Applications in Cancer Research


5. Unsupervised Learning Techniques

5.1. Introduction to Clustering Methods

5.2. K-means Clustering in Cancer Research

5.3. Hierarchical Clustering Techniques

5.4. Dimensionality Reduction Techniques (PCA, t-SNE)

5.5. Patient Stratification Using Clustering

5.6. Biomarker Discovery through Unsupervised Learning

5.7. Case Studies: Applications in Oncology

5.8. Evaluating Unsupervised Learning Models

5.9. Practical Considerations and Challenges

5.10. Future Directions in Unsupervised Learning


6. Deep Learning Fundamentals

6.1. Introduction to Neural Networks

6.2. Convolutional Neural Networks (CNNs) for Imaging Data

6.3. Recurrent Neural Networks (RNNs) for Genomic Data Analysis

6.4. Autoencoders and Their Applications in Oncology

6.5. Transfer Learning and Pre-trained Models

6.6. Case Studies: Deep Learning in Cancer Research

6.7. Training Deep Learning Models: Best Practices

6.8. Model Evaluation and Performance Metrics

6.9. Overcoming Challenges in Deep Learning

6.10. Future Trends in Deep Learning for Oncology

Section 3: Advanced Techniques and Applications

7. Radiomics and Radiogenomics

7.1. Introduction to Radiomics

7.2. Feature Extraction from Medical Images

7.3. Linking Imaging Features with Genomic Data

7.4. Clinical Applications of Radiomics

7.5. Case Studies in Radiogenomics

7.6. Workflow for Radiomic Analysis

7.7. Machine Learning Models in Radiomics

7.8. Evaluating Radiomics Models

7.9. Challenges and Solutions in Radiomics

7.10. Future Directions in Radiogenomics


8. Natural Language Processing in Cancer Research

8.1. Introduction to Natural Language Processing (NLP)

8.2. Text Mining Techniques for Clinical Notes

8.3. Analyzing Research Publications Using NLP

8.4. Automated Diagnosis through NLP

8.5. Literature Review Automation

8.6. Case Studies: NLP Applications in Oncology

8.7. Challenges in NLP for Medical Data

8.8. Best Practices for NLP Model Development

8.9. Evaluating NLP Models

8.10. Future Trends in NLP for Cancer Research


9. Integrative Omics Approaches

9.1. Introduction to Omics Data

9.2. Genomic Data Integration

9.3. Transcriptomic Data Analysis

9.4. Proteomic Data Integration

9.5. Metabolomic Data Analysis

9.6. Multi-Omics Data Integration Techniques

9.7. Case Studies in Precision Oncology

9.8. Machine Learning Models for Multi-Omics Data

9.9. Challenges in Integrative Omics

9.10. Future Directions in Omics Research

Section 4: Ethical Considerations and Future Directions

10. Ethical and Practical Considerations

10.1. Data Privacy and Security in ML Models

10.2. Ethical Issues in Machine Learning for Oncology

10.3. Bias and Fairness in Machine Learning Models

10.4. Regulatory and Compliance Issues

10.5. Ensuring Patient Consent and Data Anonymization

10.6. Addressing Disparities in Cancer Research

10.7. Case Studies on Ethical Considerations

10.8. Best Practices for Ethical Machine Learning

10.9. Legal Considerations in ML for Healthcare

10.10. Future Directions in Ethical Machine Learning


11. Future Directions in Machine Learning for Cancer Research

11.1. Emerging Trends in Machine Learning

11.2. Integration of AI with Other Technologies (IoT, Blockchain)

11.3. Advances in Computational Techniques

11.4. Machine Learning in Precision Medicine

11.5. Case Studies of Innovative Applications

11.6. Future Research Opportunities and Challenges

11.7. Collaborative Research and Data Sharing

11.8. Innovations in Cancer Treatment Planning

11.9. The Role of AI in Early Cancer Detection

11.10. The Future of Machine Learning in Oncology

Section 5: Predictive Modelling and Diagnostic Applications

12. Predictive Modelling for Cancer Diagnosis and Prognosis

12.1. Building Predictive Models

12.2. Evaluating Predictive Models

12.3. Case Studies: Predicting Cancer Onset

12.4. Case Studies: Classifying Cancer Stages

12.5. Applications: Risk Assessment

12.6. Applications: Early Detection

12.7. Challenges in Predictive Modelling

12.8. Best Practices for Model Development

12.9. Model Validation Techniques

12.10. Future Directions in Predictive Modelling


13. Diagnostic Applications of Machine Learning

13.1. Imaging-Based Diagnosis: MRI, CT, X-rays

13.2. Molecular and Genetic Diagnosis

13.3. Tumor Classification Techniques

13.4. Metastasis Detection

13.5. Case Studies: Diagnostic Applications

13.6. Challenges in Diagnostic ML Applications

13.7. Best Practices for Diagnostic Model Development

13.8. Integrating ML into Clinical Workflows

13.9. Evaluating Diagnostic Models

13.10. Future Trends in Diagnostic Applications


14. Survival Analysis and Prognostic Models

14.1. Techniques for Survival Analysis

14.2. Predicting Patient Outcomes

14.3. Case Studies: Survival Prediction for Different Cancer Types

14.4. Challenges in Survival Analysis

14.5. Best Practices for Prognostic Model Development

14.6. Evaluating Prognostic Models

14.7. Integrating Prognostic Models into Clinical Practice

14.8. Case Studies: Prognostic Applications

14.9. Future Directions in Survival Analysis

14.10. Advances in Prognostic Modelling Techniques

Section 6: Treatment Planning and Response Prediction

15. Personalized Treatment Recommendations

15.1. Building Treatment Planning Models

15.2. Predicting Treatment Outcomes

15.3. Predicting Treatment Toxicity

15.4. Case Studies: Chemotherapy

15.5. Case Studies: Radiation Therapy

15.6. Challenges in Treatment Planning

15.7. Best Practices for Personalized Treatment

15.8. Integrating ML into Treatment Planning

15.9. Evaluating Treatment Planning Models

15.10. Future Directions in Personalized Treatment


16. Breast Cancer: Diagnosis, Classification, and Predictive Models for Treatment Response

16.1. Diagnosis Using Imaging and Genomic Data

16.2. Classification Techniques for Breast Cancer

16.3. Predictive Models for Treatment Response

16.4. Case Studies: Early Detection

16.5. Case Studies: Survival Prediction

16.6. Challenges in Breast Cancer Modelling

16.7. Best Practices for Breast Cancer Research

16.8. Integrating ML in Breast Cancer Treatment

16.9. Evaluating Breast Cancer Models

16.10. Future Directions in Breast Cancer Research


17. Lung Cancer: Machine Learning in Imaging and Personalized Treatment

17.1. ML in CT and PET Imaging

17.2. Molecular Subtypes and Personalized Treatment

17.3. Tumor Segmentation Techniques

17.4. Outcome Prediction Models

17.5. Case Studies: Lung Cancer Applications

17.6. Challenges in Lung Cancer Modelling

17.7. Best Practices for Lung Cancer Research

17.8. Integrating ML in Lung Cancer Treatment

17.9. Evaluating Lung Cancer Models

17.10. Future Directions in Lung Cancer Research


18. Prostate Cancer: MRI-based Diagnosis and Predictive Models for Treatment Planning

18.1. MRI-based Diagnosis Techniques

18.2. Risk Stratification Models

18.3. Predictive Models for Treatment Planning

18.4. Case Studies: Active Surveillance

18.5. Case Studies: Prognosis

18.6. Challenges in Prostate Cancer Modelling

18.7. Best Practices for Prostate Cancer Research

18.8. Integrating ML in Prostate Cancer Treatment

18.9. Evaluating Prostate Cancer Models

18.10. Future Directions in Prostate Cancer Research


19. Colorectal Cancer: Imaging Analysis and Integrative Genomic Approaches

19.1. Endoscopic Imaging Techniques

19.2. Genomic Data Integration

19.3. Predictive Models for Early Detection

19.4. Recurrence Prediction Techniques

19.5. Case Studies: Colorectal Cancer Applications

19.6. Challenges in Colorectal Cancer Modelling

19.7. Best Practices for Colorectal Cancer Research

19.8. Integrating ML in Colorectal Cancer Treatment

19.9. Evaluating Colorectal Cancer Models

19.10. Future Directions in Colorectal Cancer Research

Section 7: Advanced Cancer Applications

20. Brain Cancer: MRI and fMRI Analysis, Genomic and Radiomic Data Integration

20.1. MRI Analysis Techniques

20.2. fMRI Analysis Techniques

20.3. Genomic Data Integration for Brain Cancer

20.4. Radiomic Data Integration for Brain Cancer

20.5. Case Studies: Glioma Classification

20.6. Case Studies: Survival Analysis

20.7. Challenges in Brain Cancer Modelling

20.8. Best Practices for Brain Cancer Research

20.9. Integrating ML in Brain Cancer Treatment

20.10. Future Directions in Brain Cancer Research


21. Pancreatic Cancer: Early Detection, Diagnosis, and Predictive Models

21.1. Early Detection Techniques

21.2. Imaging Data Analysis

21.3. Predictive Models for Surgical Outcomes

21.4. Prognostic Biomarkers Identification

21.5. Case Studies: Pancreatic Cancer Applications

21.6. Challenges in Pancreatic Cancer Modelling

21.7. Best Practices for Pancreatic Cancer Research

21.8. Integrating ML in Pancreatic Cancer Treatment

21.9. Evaluating Pancreatic Cancer Models

21.10. Future Directions in Pancreatic Cancer Research


22. Applications in Less Common Cancers

22.1. ML Applications in Rare Cancers

22.2. Predictive Models for Rare Cancers

22.3. Diagnostic Tools for Less Common Cancers

22.4. Case Studies: Advances in Rare Cancers

22.5. Challenges in Rare Cancer Modelling

22.6. Best Practices for Rare Cancer Research

22.7. Integrating ML in Rare Cancer Treatment

22.8. Evaluating Models for Less Common Cancers

22.9. Future Directions in Rare Cancer Research

22.10. Innovations in Rare Cancer Applications


23. Brain-Computer Interfaces in Oncology

23.1. Overview of Brain-Computer Interfaces (BCIs)

23.2. ML Techniques for BCIs

23.3. Case Studies: Communication Aids for Cancer Patients

23.4. Challenges in BCI Development for Oncology

23.5. Best Practices for BCI Research

23.6. Integrating ML in BCI Systems

23.7. Evaluating BCI Models

23.8. Future Directions in BCI Research

23.9. Innovations in BCI Applications for Oncology

23.10. Case Studies: Advances in BCI for Cancer Care

Section 8: Clinical Trials and Future Innovations

24. AI in Cancer Care Delivery

24.1. Workflow Automation in Oncology

24.2. Virtual Assistants in Cancer Care

24.3. Decision Support Systems

24.4. Implementing AI in Clinical Settings

24.5. Case Studies: AI in Cancer Care

24.6. Challenges in AI Implementation

24.7. Best Practices for AI in Oncology

24.8. Evaluating AI Systems in Clinical Use

24.9. Future Directions in AI for Cancer Care

24.10. Innovations in AI-driven Cancer Care


25. Clinical Trials and Translational Research

25.1. Machine Learning in Clinical Trial Design

25.2. Patient Recruitment and Monitoring

25.3. Case Studies of Successful Implementations

25.4. Challenges in ML for Clinical Trials

25.5. Best Practices for ML in Translational Research

25.6. Evaluating ML Models in Clinical Trials

25.7. Integrating ML into Clinical Trial Workflows

25.8. Future Directions in ML for Clinical Trials

25.9. Innovations in Translational Research

25.10. Case Studies: Advances in Clinical Trials


26. Future Directions and Innovations

26.1. Advances in Computational Techniques

26.2. Integration with Emerging Technologies (VR/AR, Robotics)

26.3. Future Research Challenges and Opportunities

26.4. Innovations in Cancer Research Methodologies

26.5. Collaborative Research and Data Sharing

26.6. Case Studies of Innovative Applications

26.7. Future Trends in Machine Learning for Oncology

26.8. The Role of AI in Future Cancer Research

26.9. Innovations in Cancer Treatment Planning

26.10. Future Prospects for ML in Oncology


27. Conclusion and Final Comments

27.1. Summary of Key Applications

27.2. Impact of Machine Learning on Cancer Research and Treatment

27.3. Encouragement for Continued Innovation and Research

27.4. Final Thoughts and Insights

27.5. Resources for Further Learning

27.6. Future Prospects for Researchers and Practitioners

27.7. Addressing Ongoing Challenges in Oncology

27.8. The Role of Interdisciplinary Research

27.9. Building a Collaborative Research Environment

27.10. Closing Remarks and Vision for the Future

Product details

  • Edition: 1
  • Latest edition
  • Published: June 1, 2027
  • Language: English

About the authors

Sanjay Saxena

Author

Dr. Sanjay Saxena is an Assistant Professor in the Department of Computer Science and Engineering at IIIT Bhubaneswar, India. He obtained his Ph.D. from the Indian Institute of Technology (BHU), Varanasi, and completed his postdoctoral research at the Artificial Intelligence in Biomedical Imaging Lab, University of Pennsylvania, USA. Dr. Saxena's primary research area involves developing AI-based methods for brain cancer analysis, with a broader focus on Data Science, Machine Learning, Deep Learning, and the emerging fields of Radiomics and Radiogenomics. His tenure under Prof. Davatzikos at the University of Pennsylvania was instrumental in his significant learning about Radiomics/Radiogenomics. Dr. Saxena is a member of prestigious organisations such as IEEE, the Society of Neuro-Oncology, ACM, and the New York Academy of Science. He has presented his work at globally recognised universities such as like Imperial College London, Stony Brook University, and Vienna University of Technology. and has made substantial scholarly contributions, with several peer-reviewed Journals, conference publications, book chapters, and two books to his name, advancing the intersection of AI and human cancer research.

Affiliations and expertise
Assistant Professor, Department of Computer Science and Engineering, International Institute of Information Technology, Bhubaneswar, India

Jasjit S. Suri

Author

Dr. Jasjit Suri, PhD, MBA, is a renowned innovator and scientist. He received the Director General’s Gold Medal in 1980 and is a Fellow of several prestigious organizations, including the American Institute of Medical and Biological Engineering and the Institute of Electrical and Electronics Engineers. Dr. Suri has been honored with lifetime achievement awards from Marcus, NJ, USA, and Graphics Era University, India. He has published nearly 300 peer-reviewed AI articles, 100 books, and holds 100 innovations/trademarks, achieving an H-index of nearly 100 with about 43,000 citations. Dr. Suri has served as chairman of AtheroPoint, IEEE Denver section, and as an advisory board member to various healthcare industries and universities globally.

Affiliations and expertise
Chairman, AtheroPoint LLC, USA