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Elsevier

Handbook of Epigenetics

The New Molecular and Medical Genetics

Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical applicati… Read more

Description

Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging.

The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders.

Key features

  • Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field
  • Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine
  • Written at a verbal and technical level that can be understood by scientists and college students
  • Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials

Readership

Researchers working in genetics, biology, molecular biology, pharmaceutical science, and clinical therapy; advanced undergraduate students, graduate students, university researchers, pharmaceutical company and biotechnology researchers interested in drug development and therapies

Table of contents

1. An Overview of Epigenetics

SECTION I: Molecular Mechanisms of Epigenetics

2. Mechanisms of DNA Methylation

3. Molecular Mechanisms of Histone Modification

4. The Epigenetics of Non-coding RNA

SECTION II: Additional Epigenetic Processes

5. Prions in Epigenetic Inheritance

6. Chromosomal Position Effects

7. Polycomb-group Proteins and Epigenetics

SECTION III: Epigenetic Technology

8. Analyses of Gene-specific DNA Methylation

9. Methods for Assessing Genome-wide DNA Methylation

10. Determination of Histone Modifications of Specific Genes

11. Analyses of Genome-wide Histone Modifications

12. Techniques for Genome-wide Expression of Non-coding RNA

13. Computational Epigenetics

SECTION IV: Model Organisms of Epigenetics

14. Epigenetics of Lower Organisms

15. Drosophila Epigenetics

16. Models of Mouse Epigenetic Inheritance

17. Plant Epigenetics

SECTION V: Metabolism and Epigenetics

18. Metabolic Effects on DNA Methylation

19. Metabolism and Chromatin Dynamics

SECTION VI: Functions of Epigenetics

20. Epigenetics, Stem Cells and Cellular Differentiation

21. Regeneration Epigenetics

22. Epigenetics of X-chromosome Inactivation

23. Genomic Imprinting

24. Epigenetics of Memory Processes

25. Transgenerational Epigenetics

26. Aging Epigenetics

SECTION VII: Evolutionary Epigenetics

27. Evolution of Epigenetic Mechanisms

28. Adaptive Evolution and Epigenetics

SECTION VIII: Epigenetic Epidemiology

29. The Effects of Diet on Epigenetic Processes

30. Environmental Agents and Epigenetic Effects

31. Impact of Infective Agents on the Epigenome

32. Population Pharmacoepigenomics

SECTION IX: Epigenetics and Human Disease

33. Cancer Epigenetics

34. The Role of Epigenetics in Immune Disorders

35. Epigenetics of Brain Disorders

36. The Epigenetics of Metabolic Diseases

37. Imprinting Defects in Humans

SECTION X: Epigenetic Therapy

38. DNA Demethylating Agents in Clinical Medicine

39. Clinical Applications of Histone Deacetylase Inhibitors

40. Combination Epigenetic Therapy

SECTION XI: The Future of Epigenetics

41. New Directions for Epigenetic Research

Product details

About the editor

TO

Trygve O. Tollefsbol

Dr. Tollefsbol is a Distinguished Professor at the University of Alabama at Birmingham. He holds doctorates in molecular biology and osteopathic medicine, trained with National Academy of Science members and has over 200 peer-reviewed publications. Reports highlighting the translatability to the lay public of the discoveries made in his laboratory have appeared in international media representing >50 million readers. Dr. Tollefsbol has been featured as an Investigator in the Spotlight by the NIH as well as a Scientist in the Spotlight by ScienceNow. He is an Associate Editor for Frontiers in Genetics, a contributor to Lewin’s GENES classic textbook and Lead Editor for Elsevier’s Translational Epigenetics Series. Dr. Tollefsbol has been named a “Highly Ranked Scholar” worldwide (ScholarGPS). He has been invited for numerous endowed keynote presentations, his research has been highlighted in eScience News and ScienceDaily and he has published 20 scholarly books on topics related to his research.
Affiliations and expertise
Distinguished Professor of Biology, University of Alabama at Birmingham, AL, USA

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