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Handbook of Cancer Treatment-Related Symptoms and Toxicities
- 1st Edition - February 22, 2021
- Authors: Vamsidhar Velcheti, Salman R Punekar
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 6 7 2 4 1 - 2
Early recognition and management of adverse effects of cancer treatments are essential for optimal care of patients with cancer, and drastically different approaches are required… Read more
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Request a sales quoteEarly recognition and management of adverse effects of cancer treatments are essential for optimal care of patients with cancer, and drastically different approaches are required for different physiologic reactions. Handbook of Cancer Treatment-Related Symptoms and Toxicities is a focused, one-stop resource that enables clinicians to quickly find up-to-date, reliable information needed at the point of care. The high-yield approach prioritizes the most common toxicities associated with cancer treatment, and concise, templated chapters offer fast access to information needed in day-to-day practice.
- Presents a user-friendly overview of cancer treatment-related symptoms and toxicities management in a practical, easy-to-use format, allowing you to quickly find information in one convenient, concise resource.
- Covers systemic and radiation therapies, including chemotherapy, immunotherapy, targeted therapies, and radiation therapy, detailing symptoms of each toxicity to confirm your diagnosis.
- Overviews pharmacologic and non-pharmacologic approaches to symptom management.
- Offers recommendations for mitigating toxicities in high-risk patients.
- Discusses key topics such as management of infusion reactions, when the need for biopsy is warranted, and the unique challenges posed by novel immunotherapies.
- Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Medical oncologists and hematologists – practicing and trainee; emergency MDs and hospitalists
- Cover Image
- Title Page
- Copyright
- Dedication
- Contributors
- Preface
- Acknowledgments
- Table of Contents
- PART 1 Cytotoxic Chemotherapy
- CHAPTER 1 Mechanisms of Cancer-Directed Therapies
- Mechanisms of Cancer-Directed Therapies
- References
- CHAPTER 2 Neutropenic Complications of Chemotherapy
- Abstract
- Introduction
- Etiology of Neutropenia
- Risk Assessment of Adults With Chemotherapy-Induced Neutropenia
- Workup of Neutropenic Fever
- Pharmacological Approaches for Management and Treatment
- Nonpharmacological Approaches for Management and Treatment
- References
- CHAPTER 3 Chemotherapy-Induced Anemia
- Abstract
- Introduction
- Grading of Anemia
- Agents Causative of Anemia
- Supportive Care
- Pharmacologic Approaches to Anemia
- References
- CHAPTER 4 Cancer Treatment-Related Thrombocytopenia
- Abstract
- Introduction
- Mechanisms of Thrombocytopenia
- Diagnostic Workup of Thrombocytopenia
- Treatment of Thrombocytopenia
- References
- CHAPTER 5 Oral Mucositis
- Abstract
- Introduction
- Incidence of Oral Mucositis
- Differential Diagnoses
- Etiology and Mechanism of Action of Mucositis
- Grading of Mucositis
- Mucositis Management
- References
- CHAPTER 6 Gastrointestinal Complications of Chemotherapy
- Abstract
- Introduction
- Esophageal Complications of Chemotherapy
- Chemotherapy-Induced Nausea and Vomiting
- Classification of Chemotherapy-Induced Nausea and Vomiting
- Risk Factors for the Development of Chemotherapy-Induced Nausea and Vomiting
- Pathophysiology of Chemotherapy-Induced Nausea and Vomiting
- Management and Prevention of Chemotherapy-Induced Nausea and Vomiting
- Antiemetic Regimens Based on Emetogenicity of Chemotherapy
- Management of Anticipatory Emesis
- Management of Breakthrough and Refractory Emesis
- Nonpharmacological Approaches for Management of CINV
- Enterocolitis
- Constipation
- Chemotherapy-Induced Diarrhea (CID)
- Evaluation and Management of Chemotherapy-Induced Diarrhea
- Hepatotoxicity
- Conclusion
- References
- CHAPTER 7 Neurological Complications of Chemotherapy
- Abstract
- Introduction
- Chemotherapy-Related Neurotoxicity
- Chemotherapy-Induced Neurocognitive Deficit (Chemo-Brain)
- References
- CHAPTER 8 Pulmonary Toxicities of Chemotherapy
- Abstract
- Introduction
- Subtypes of Chemotherapy-Associated Pulmonary Toxicity
- Diagnostic Workup of Suspected Chemotherapy-Associated Pulmonary Toxicity
- Cytotoxic Chemotherapy Agents and Mechanisms of Action
- Approach to Management
- Monitoring and Preventative Strategies
- References
- CHAPTER 9 Dermatological Toxicities of Chemotherapy
- Abstract
- Introduction
- Chemotherapy-Induced Alopecia
- Hypersensitivity Reactions
- Acral Erythema
- Extravasation
- Hyperpigmentation
- Photosensitivity
- Radiation Recall
- Nail Changes
- Conclusion
- References
- CHAPTER 10 Cardiovascular Toxicities of Chemotherapy
- Abstract
- Introduction
- Antineoplastic Antibiotics
- Alkylating Agents
- Microtubule-Directed Agents
- Antimetabolites
- Conclusion
- References
- CHAPTER 11 Cancer Treatment Infusion Reactions
- Abstract
- Introduction
- Recognition of Infusion Reactions
- Prevention and Treatment of Infusion Reactions
- Skin Testing
- Infusion Reactions Caused by Monoclonal Antibodies
- Infusion Reactions Caused by Chemotherapy Drugs
- Desensitization
- Conclusion
- References
- PART 2 Targeted Therapy
- CHAPTER 12 Mechanisms of Toxicities Associated With Targeted Therapy
- Abstract
- Introduction
- Receptor Tyrosine Kinases (RTKs)
- RAS/RAF/MEK/ERK Pathway
- Conclusion
- References
- CHAPTER 13 Gastrointestinal Toxicities of Targeted Therapy
- Abstract
- Introduction
- Diarrhea
- EGFR–Targeting Agents
- c-KIT–Targeting Agents
- VEGF–Targeting Agents
- CDK4/6 Inhibitors
- Mitogen-Activated Protein Kinase Inhibitors
- Management of Diarrhea
- Pharmacological Management of Diarrhea
- Targeted Therapy-Related Nausea and Vomiting
- ALK Targeted–Therapy and Nausea and Vomiting
- c-MET Targeted–Therapy and Gastrointestinal Side Effects
- Pharmacological Management
- Nonpharmacological Treatment
- Hepatotoxicity
- Assessment of Liver Toxicity
- Management
- Gastrointestinal Perforation
- References
- CHAPTER 14 Pulmonary Toxicities of Targeted Therapy
- Abstract
- Introduction
- Agents and Mechanism of Action
- Specific EGFR–Targeting Agents
- Anaplastic Lymphoma Kinase (ALK) Inhibitors
- BCR-ABL1 Tyrosine Kinase Inhibitors
- Vascular Endothelial Growth Factor (VEGF) Inhibitors
- Human Epidermal Growth Factor Receptor 2(HER2)-Targeting Antibodies
- CD20-Targeting Agents
- EGFR-Targeting Antibodies
- Mitogen-Activated Protein Kinase (MEK) Inhibitors
- Polyadenosine Diphosphate-Ribose Polymerase (PARP) Inhibitors
- Cyclin-Dependent Kinase (CDK) 4/6 Inhibitors
- Phosphatidylinositol-3-Kinase (PI3K) Inhibitors
- mTOR Inhibitors
- Pharmacological Approaches for the Management of Pulmonary Toxicities
- Rechallenge
- Nonpharmacological Approaches for Management of Pulmonary Toxicities
- References
- CHAPTER 15 Dermatological Toxicities of Targeted Therapy
- Abstract
- Introduction
- Acneiform Rash
- Mechanism of Rash and the EGFR Pathway
- Approved EGFR–Targeting Therapies
- Hand-Foot Skin Reaction
- Stomatitis
- Alopecia
- Cutaneous Squamous Cell Carcinoma
- References
- CHAPTER 16 Cardiovascular Toxicities of Targeted Therapy
- Abstract
- Introduction
- Targeted Therapies Associated With Cardiotoxicity
- Common Cardiotoxicities Caused by Targeted Therapies
- Hypertension
- Congestive Heart Failure
- Thromboembolic Events
- Venous Thromboembolic Events (VTEs)
- Arrhythmias
- Pleural Effusions
- References
- PART 3 Immunotherapy
- CHAPTER 17 Mechanisms of Immune-Related Adverse Events
- Abstract
- Introduction
- Physiological Pathways Involved in the Regulation of Immune Homeostasis
- Pathophysiology of Immune-Related Adverse Events (irAEs)
- Shared Antigens, Cross Presentation of Neoantigens and T Cell Epitope Spreading
- Dysregulation of Other Immune Cells
- Autoantibodies
- Cytokines
- Genetic Polymorphisms
- Environmental Modulation of Immune Responses
- Specific Immunotherapeutic Agents and their Associated Toxicities
- Conclusion
- References
- CHAPTER 18 Endocrine Toxicities of Immunotherapy
- Abstract
- Introduction
- Agents and Mechanism of Action
- Pharmacological Management of Toxicities
- References
- CHAPTER 19 Gastrointestinal Toxicities of Immunotherapy
- Abstract
- Introduction
- Description
- Agents and Mechanism of Action
- Pharmacologic Approaches for Management and Treatment
- Nonpharmacological Approaches for Management and Treatment
- References
- CHAPTER 20 Neurological Toxicities of Immunotherapy
- Abstract
- Introduction
- Agents
- Clinical Approach and Pharmacological Management of Toxicity
- Nonpharmacological Management of Toxicities
- References
- CHAPTER 21 Pulmonary Toxicities of Immunotherapy
- Abstract
- Introduction
- Immunotherapy-related Pneumonitis
- Agents
- Pharmacological Approaches for Management and Treatment
- Nonpharmacological Approaches for Management and Treatment
- References
- CHAPTER 22 Dermatologic Toxicities of Immunotherapy
- Abstract
- Introduction
- Description
- Diagnostic Workup
- Agents and Mechanisms of Action
- Pharmacological Approaches for Management and Treatment
- Nonpharmacological Approaches for Management and Treatment
- References
- CHAPTER 23 Cardivascular Toxicities of Immunotherapy
- Abstract
- Introduction
- Description
- Agents and Mechanism of Action
- Pharmacological Approaches for Management and Treatment
- Nonpharmacological Approaches for Management and Treatment
- References
- CHAPTER 24 Rheumatological Toxicities of Immunotherapy
- Abstract
- Introduction
- Mechanism of Action
- The Agents
- Prevalence
- Specific Rheumatic Immune-Related Adverse Events
- Diagnosis and Management Strategies
- Use of Immune Checkpoint Inhibitors in Patients With Preexisting Autoimmune Diseases
- Conclusion
- References
- PART 4 Radiation Therapy
- CHAPTER 25 Mechanisms of Radiation-Related Toxicities
- Abstract
- Introduction
- Types of Radiation-Related Toxicities
- Genetic Determinants of Radiation Toxicity
- Technical Advances in Precision Radiotherapy Can Reduce Toxicity
- Medical Therapies Alter Radiation Response
- Conclusions
- References
- CHAPTER 26 Mucosal and Esophageal Toxicites of Radiation Therapy
- Abstract
- Introduction
- Description
- Risk Factors
- Mechanism of Action
- Pharmacological Approaches for Management and Treatment
- Nonpharmacological Approaches for Management and Treatment
- References
- CHAPTER 27 Dermatologic Toxicities of Radiation Therapy
- Abstract
- Introduction
- Description
- Pathogenesis
- Factors Influencing the Onset, Duration, and Intensity of the Radiation Dermatitis
- Pharmacological Approaches for Management and Treatment
- Nonpharmacological Approaches for Management and Treatment
- References
- CHAPTER 28 Pulmonary Toxicities of Radiation Therapy
- Abstract
- Introduction
- Characteristics of Radiation-induced Lung Injury
- Risk of Pneumonitis With Various Treatment Modalities
- Pharmacological Approaches for Management and Treatment
- Nonpharmacological Approaches for Management and Treatment
- References
- CHAPTER 29 Cardiovascular Toxicities of Radiation Therapy
- Abstract
- Introduction
- Description
- Symptoms
- Screening and Diagnostic Workup
- Imaging
- Grading
- Mechanisms of Action
- Pharmacological Approaches for Management and Treatment
- Nonpharmacological Approaches for Management and Treatment
- References
- Index
- No. of pages: 352
- Language: English
- Edition: 1
- Published: February 22, 2021
- Imprint: Elsevier
- Paperback ISBN: 9780323672412
VV
Vamsidhar Velcheti
Dr. Vamsidhar (Vamsi) Velcheti is Associate Professor and Medical Director of the Thoracic Oncology Program at
NYU Langone/Laura and Isaac Perlmutter Cancer Center In New York, New York. He is the author of Velcheti Handbook of Cancer Treatment-Related Symptoms and Toxicities, a new title in Elsevier’s oncology list that published in March 2021.
Affiliations and expertise
Associate Professor, NYU Grossman School of Medicine; Medical Director, Thoracic Oncology Program, NYU Langone Health, Perlmutter Cancer Center, New York, New YorkSP
Salman R Punekar
Affiliations and expertise
Fellow at NYU Langone Health, Perlmutter Cancer Center, Department of Hematology and Oncology, New York, New York