Haemonchus Contortus and Haemonchosis – Past, Present and Future Trends

1st Edition, Volume 93 - May 25, 2016
Editors: Robin Gasser, Georg v. Samson-Himmelstjerna
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 1 0 3 9 5 - 1
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 0 3 9 6 - 8

Haemonchus Contortus and Haemonchosis – Past, Present and Future Trends, the latest in the Advances in Parasitology series first published in 1963, contains comprehensive an… Read more

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Haemonchus Contortus and Haemonchosis – Past, Present and Future Trends, the latest in the Advances in Parasitology series first published in 1963, contains comprehensive and up-to-date reviews on all areas of interest in contemporary parasitology. The series includes medical studies of parasites of major influence, such as Plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which help to shape current thinking and applications. The 2014 impact factor is 6.226.

Series Editor
- Editorial Board
Preface
Chapter One. Evolution and Biogeography of Haemonchus contortus: Linking Faunal Dynamics in Space and Time
- 1. Introduction
- 2. Haemonchus: History and Biodiversity
- 3. Phylogeny and Biogeography: Out of Africa
- 4. Domestication, Geographical Expansion and Invasion
- 5. Host Range for Haemonchus contortus
- 6. Host and Geographical Colonization in Faunal Assembly
- 7. Climate Impacts Integrating Historical Perspectives
- 8. Understanding Diversity: Some Recommendations
Chapter Two. Genetic Diversity and Population Structure of Haemonchus contortus
- 1. Introduction
- 2. Background Information on Reproduction and Genetics
- 3. Genetic Diversity and Population Structure of Haemonchus contortus in the Field
- 4. Consequences of Haemonchus contortus Population Structure for the Emergence and Spread of Anthelmintic Resistance in the Field
- 5. Genetic and Phenotypic Variation in Laboratory Strains
- 6. Concluding Remarks
Chapter Three. The Biochemistry of Haemonchus contortus and Other Parasitic Nematodes
- 1. Introduction
- 2. Ecosystems of Haemonchus contortus Life Cycle Stages
- 3. Gene Expression in Parasitic Life Cycle Stages
- 4. Energy Metabolism in Nematodes
- 5. Amino Acid Metabolism
- 6. Nucleic Acid Metabolism
- 7. Lipid Metabolsim
- 8. Structure and Biochemical Composition of the Cuticle
- 9. Tubulin as a Major Structural Component and Drug Target
- 10. Nervous System in Nematodes
- 11. Biochemistry of Drug Resistance
- 12. Conclusions
Chapter Four. The Pathophysiology, Ecology and Epidemiology of Haemonchus contortus Infection in Small Ruminants
- 1. Introduction
- 2. Occurrence and Importance
- 3. Pathogenesis and Disease
- 4. Ecology
- 5. Epidemiology
- 6. Prediction of the Occurrence of H. contortus
- 7. Conclusions
Chapter Five. The Identification of Haemonchus Species and Diagnosis of Haemonchosis
- 1. Introduction
- 2. Morphological Approaches for Identifying Haemonchus contortus
- 3. Molecular Methods for Identifying Haemonchus
- 4. Immunological Methods for Diagnosing Haemonchosis
- 5. Final Thoughts
Chapter Six. Diagnosis, Treatment and Management of Haemonchus contortus in Small Ruminants
- 1. Introduction
- 2. Diagnosis and Disease Monitoring
- 3. Anthelmintic Treatment
- 4. Nonchemical Control
- 5. Preventative Programmes
- 6. Conclusions
Chapter Seven. Interactions Between Nutrition and Infections With Haemonchus contortus and Related Gastrointestinal Nematodes in Small Ruminants
- 1. Introduction
- 2. Quantitative Aspects
- 3. Qualitative Aspects
- 4. Conclusions
Chapter Eight. Immunity to Haemonchus contortus and Vaccine Development
- 1. Introduction
- 2. The Immunology of Host Protection Against Haemonchus contortus
- 3. Development of Vaccines
- 4. Recombinant Subunit Vaccines
- 5. Concluding Remarks
Chapter Nine. Anthelmintic Resistance in Haemonchus contortus: History, Mechanisms and Diagnosis
- 1. Introduction
- 2. History of Anthelmintic Resistance
- 3. Mechanisms of Resistance
- 4. Diagnosis of Resistance
- 5. Conclusions
Chapter Ten. Haemonchus contortus: Applications in Drug Discovery
- 1. Introduction
- 2. Drug Discovery
- 3. Perspectives on H. contortus and Drug Discovery
- 4. Challenges and Research Opportunities
Chapter Eleven. Gaining Insights Into the Pharmacology of Anthelmintics Using Haemonchus contortus as a Model Nematode
- 1. Introduction
- 2. Background on the Pharmacology of Anthelmintic Drugs
- 3. Assessment of Parasite Exposure to Anthelmintic Drugs Using Haemonchus contortus as a Target Nematode
- 4. Modulation of Drug Efflux Transport: Impact on Clinical Response Against Resistant Haemonchus contortus
- 5. Pharmacological Evaluation of Drug-Combined Therapy Against Resistant Haemonchus contortus
- 6. Concluding Remarks
Chapter Twelve. Understanding Haemonchus contortus Better Through Genomics and Transcriptomics
- 1. Introduction
- 2. Background on Haemonchus and Haemonchosis
- 3. Caenorhabditis elegans and WormBase: Key Resources for Understanding the Molecular Biology of H. contortus
- 4. Pregenomic Transcriptomic Studies of H. contortus
- 5. Genomes and Transcriptomes of H. contortus – a Window to Understanding the Molecular Biology of the Worm
- 6. Prospects
Chapter Thirteen. Haemonchus contortus: Genome Structure, Organization and Comparative Genomics
- 1. Introduction
- 2. From Draft Assembly to Reference Genome
- 3. Genome Structure
- 4. Genome Content
- 5. Future Directions
Chapter Fourteen. Functional Genomics Tools for Haemonchus contortus and Lessons From Other Helminths
- 1. Introduction
- 2. Gene Silencing by RNAi
- 3. How to Progress RNAi as a Functional Genomics Tool for H. contortus
- 4. Transgenic Approaches to Identify Essential Gene Function
- 5. Functional Genomics Using CRISPR/CAS Genome Editing
- 6. Concluding Remarks
Index
Contents of Volumes in This Series
- Volume 41
- Volume 42
- Volume 43
- Volume 44
- Volume 45
- Volume 46
- Volume 47
- Volume 48
- Volume 49
- Volume 50
- Volume 51
- Volume 52
- Volume 53
- Volume 54
- Volume 55
- Volume 56
- Volume 57
- Volume 58
- Volume 59
- Volume 60
- Volume 61
- Volume 62
- Volume 63
- Volume 64
- Volume 65
- Volume 66
- Volume 67
- Volume 68
- Volume 69
- Volume 70
- Volume 71
- Volume 72
- Volume 73
- Volume 74
- Volume 75
- Volume 76
- Volume 77
- Volume 78
- Volume 79
- Volume 80
- Volume 81
- Volume 82
- Volume 83
- Volume 84
- Volume 85
- Volume 86
- Volume 87
- Volume 88
- Volume 89
- Volume 90
- Volume 91
- Volume 92

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Haemonchus Contortus and Haemonchosis – Past, Present and Future Trends

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Robin Gasser

Georg v. Samson-Himmelstjerna