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Gunderson and Tepper’s Clinical Radiation Oncology

  • 6th Edition - December 21, 2025
  • Latest edition
  • Editors: Robert L. Foote, Jeff M. Michalski, Akila Viswanathan, Joel E. Tepper
  • Language: English

Expertly written and meticulously edited to ensure scientifically accurate, accessible content throughout, Gunderson and Tepper’s Clinical Radiation Oncology, 6th Edition, provid… Read more

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Description

Expertly written and meticulously edited to ensure scientifically accurate, accessible content throughout, Gunderson and Tepper’s Clinical Radiation Oncology, 6th Edition, provides complete, multidisciplinary coverage of this complex and dynamic field. Concise, templated chapters cover the basic biology of oncologic disease processes as well as updated treatment algorithms, the latest clinical guidelines, and state-of-the-art techniques and modalities. User-friendly elements such as summarized key issues, full-color formatting, extensive use of tables and figures, and access to videos online make this reference an ideal resource for every member of the radiation oncology team.

Key features

  • Divides content into three distinct sections for quick access to information: Scientific Foundations, Techniques and Modalities, and Disease Sites. Disease Site chapters include overviews summarizing the most important issues and concluding discussions on controversies and problems
  • Provides expert guidance on single-modality and combined-modality approaches, as well as outcome data including disease control, survival, and treatment tolerance
  • Contains a new chapter on artificial intelligence in radiation, as well as up-to-date coverage of advancements in interventional radiology tumor ablation techniques and associated outcomes; updated guidance on using Intraoperative Radiation Therapy (IORT) as a radiation dose escalation tool; and increased coverage of proton therapy
  • Features more than 1,000 images―detailed anatomy drawings, radiographic images, and more - that provide outstanding visual support for every area of the text
  • Covers key topics such as brachytherapy, precision radiation therapy, palliative radiotherapy, quality and safety, image-guided radiotherapy (IGRT), and stereotactic radiosurgery
  • Includes access to videos on intraoperative irradiation, prostate brachytherapy, penile brachytherapy, and ocular melanoma
  • An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date

Readership

Radiation oncologists – practitioners, fellows, and residents

Table of contents

SECTION 1 Scientific Foundations of Radiation Oncology
PART A Radiobiology

1. The Biological Basis of Radiation Oncology

2. Molecular and Cellular Biology

3. Dose-Response Modifiers in Radiation Therapy

4. Interaction of Chemotherapy and Radiation

5. Modulation of Radiation Response with Molecularly Targeted Therapy

6. Cancer Immunity and Radiation

PART B Physics

7. Radiation Oncology Physics

8. Radiation Physics: Stereotactic

9. Radiation Physics: Charged Particle Therapy

10. Artificial Intelligence in Clinical Radiation Oncology

PART C related cancer Disciplines

11. Surgical Principles

12. Principles of Systemic Cancer Therapy

13. Imaging in Oncology

14. Nuclear Medicine and PET

15. Tumor Ablation in Interventional Radiology

16. Overview of Oncology Clinical Trial Design

17. Health Services Research in Radiation Oncology

18. Radiation Therapy in the Older Adult

19. Palliative Radiation Medicine

20. Late Effects After Radiation

SECTION 2 Techniques and Modalities

21. Quality and Safety in Radiation Oncology

22. Principles and Practice of Brachytherapy

23. Intensity-Modulated and Image-Guided Radiotherapy

24. Intraoperative Irradiation

25. Total Body Irradiation

26. Charged Particle Radiotherapy

27. Radiopharmaceutical Therapy

28. Radiotherapy and Immunotherapy

29. Stereotactic Irradiation: CNS Tumors

30. Stereotactic Body Irradiation: Extracranial Tumors

31. Metastatic Disease: Bone, Spinal Cord, Brain, Liver, and Lung

SECTION 3 Disease Sites
PART A central nervous System tumors

32. Central Nervous System Tumors: Overview

33. Low-Grade Gliomas

34. High-Grade Gliomas

35. Benign Brain Tumors: Meningiomas and Vestibular Schwannomas

36. Pituitary Tumors and Craniopharyngiomas

37. Spinal Cord Tumors

38. Ocular, Orbital, and Optic Nerve Tumors

PART B Head and neck tumors

39. Overview

40. Oral Cavity

41. Oropharyngeal Cancer

42. Nasopharyngeal Carcinoma

43. Larynx and Hypopharynx Cancer

44. Sinonasal Cancer

45. Salivary Gland Malignancies

46. Thyroid Cancer

47. Unknown Head and Neck Primary Site

48. Management of the Neck

49. Cutaneous Carcinoma

50. Melanoma

PART C thoracic neoplasms

51. Overview

52. Small-Cell Lung Cancer

53. Non-small Cell Lung Cancer

54. Uncommon Thoracic Tumors

PART D Gastrointestinal tumors

55. Gastrointestinal Tumors Overview

56. Esophagus-Gastric Cancer

57. Pancreatic Cancer

58. Hepatobiliary Cancer

59. Colon Cancer

60. Rectal Cancer

61. Anal Carcinoma

PART E Genitourinary tumors

62. Overview

63. Prostate Cancer

64. Bladder Cancer

65. Testicular Cancer

66. Kidney and Ureteral Carcinoma

67. Penile Cancer

PART F Gynecologic tumors

68. Overview

69. Cervical Cancer

70. Endometrial Cancer

71. Cancers of the Vulva and Vagina

72. Ovarian Cancer

PART G Breast cancer

73. Overview

74. Noninvasive Breast Cancer

75. Breast Cancer: Stages I and II

76. Locally Advanced and Inflammatory Breast Cancer

PART H Sarcoma and Benign Disease

77. Soft-Tissue Sarcoma

78. Benign Diseases

PART I childhood cancers

79. Overview

80. Central Nervous System Tumors in Children

81. Pediatric Soft Tissue Sarcomas

82. Pediatric Sarcomas of Bone

83. Wilms’ Tumor

84. Retinoblastoma

85. Neuroblastoma

86. Pediatric Leukemia and Lymphoma

87. Pediatric Hodgkin Lymphoma

88. Rare Pediatric Tumors

PART J Lymphoma and Hematologic Malignancies

89. Overview

90. Hodgkin Lymphoma

91. Non-Hodgkin Lymphoma

92. Multiple Myeloma and Other Plasma Cell Neoplasms

93. Mycosis Fungoides

INDEX

Product details

  • Edition: 6
  • Latest edition
  • Published: January 13, 2026
  • Language: English

About the editors

RF

Robert L. Foote

Affiliations and expertise
Hitachi Professor of Radiation Oncology Research, Mayo Clinic Alix School of Medicine, Department of Radiation Oncology Chair, Mayo Clinic Rochester Cancer Coordinating Committee, Mayo Clinic Cancer Center

JM

Jeff M. Michalski

Affiliations and expertise
Carlos A. Perez Distinguished Professor, Vice-Chairman and Director for Clinical Programs, Washington University School of Medicine Siteman Cancer Center, Department of Radiation Oncology

AV

Akila Viswanathan

Affiliations and expertise
Director, Johns Hopkins Radiation Oncology and Molecular Radiation Sciences, Professor of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine

JT

Joel E. Tepper

Affiliations and expertise
Hector MacLean Distinguished Professor of Cancer Research, Department of Radiation Oncology, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

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