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Growth, Nutrition, and Metabolism of Cells In Culture V3
- 1st Edition - January 1, 1977
- Editor: George Rothblat
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 5 9 8 3 0 3 - 7
- Paperback ISBN:9 7 8 - 0 - 1 2 - 4 1 4 2 8 2 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 1 4 5 9 8 - 5
Growth, Nutrition, and Metabolism of Cells in Culture, Volume 3, focuses on a number of specific, timely areas of research that make use of cell and tissue culture. The major theme… Read more
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Request a sales quoteGrowth, Nutrition, and Metabolism of Cells in Culture, Volume 3, focuses on a number of specific, timely areas of research that make use of cell and tissue culture. The major theme of this volume is growth and its regulation in animal cells. The book includes studies on the role of growth factors in cell culture systems; the effects of cyclic nucleotides in cell proliferation in culture; metabolic regulation during the cell cycle; and the role of the cell surface in growth and metabolic regulation. There are also separate chapters on aspects of abnormal cell growth and metabolism; DNA repair; genetic analysis using cell fusion techniques; the growth of vascular cells in culture for atherosclerosis research; the culture of haploid vertebrate cells for genetic analysis of cell function; data on haploid cell culture; and the value of using cell cultures to test for the possible toxicity of various pharmacologic agents.
List of Contributors
Preface
Contents of Other Volumes
I. Cell, Tissue, and Organoid Cultures of Blood Vessels
I. Introduction
II. Structural and Functional Heterogeneity of Vasculature
III. Tissue and Organoid Cultures
IV. Cell Cultures
References
2. Haploid Vertebrate Cell Cultures
I. Introduction
II. Culture Methods
III. Isolation of Variant Cell Lines
IV. Haploid-Diploid Comparisons as a Test for Mutation
V. The Nature of Haploidy in Vertebrate Cells
VI. Summary
References
3. Cell Fusion in Genetic Analysis
I. Introduction
II. Cell Fusion
III. Cell Hybridization
IV. Human Chromosome Mapping
V. Human Regional Chromosome Assignment
VI. Studies of Primate Evolution
VII. Regulation of Differentiated Functions in Somatic Cell Hybrids
VIII. Mapping of the Integration Sites of Oncogenic Viruses in Transformed Cells
IX. Genetic Control of Malignancy
X. Genetics of Cancer in Man
References
4. The Structural and Functional Roles of Lipids in the Surface of Animal Cells Grown In Vitro
I. The Fluid State of Lipid Bilayers
II. Probes of Membrane Structure
III. Lipid Alterations in Cultured Cells
IV. Lipid Structure-Function Relationships
References
5. Metabolic Regulation in the Cell Cycle
I. Introduction
II. The Methodology of Cell Cycle Analysis (Optimal Conditions, Choice of Cells, and Sampling Intervals)
III. Temporal Regulation of Gene Expression
IV. Changing Perspectives of the Cell Cycle
References
6. DNA Repair in Cultured Mammalian Cells
I. Introduction
II. Systems of DNA Repair in Prokaryotes
III. Measurement of DNA Repair in Cultured Mammalian Cells
IV. Concluding Remarks
References
7. Control of Animal Cell Proliferation
I. Introduction
II. Signals
III. Transmitters
IV. Receptors
V. Machines
VI. Programs and Clocks
References
8. Cyclic Nucleotides
I. Introduction
II. Cyclic Nucleotide Formation, Intracellular Interactions, and Degradation
HI. Role of Cyclic Nucleotides in Cellular Regulation
IV. Summary
References
9. Viral Transformation of Cultured Mammalian Cells as a Multistep Process
I. Introduction and Nomenclature
II. Transforming Agents
III. Initiation of Transformation
IV. Maintenance of Transformed Phenotype and Reversion
V. Consequences of Transformation
VI. Possible Pitfalls
VII. Conclusion
References
10. Chemical Carcinogenesis In Vitro
I. Introduction
II. Use of Cell Culture Systems to Study the Biological Effects of Chemical Carcinogens
III. Use of Cell Culture Systems to Study Mechanisms of Chemical Carcinogenesis
IV. Perspectives
References
11. Toxicity Testing In Vitro
I. Introduction
II. Toxicology and In Vitro Studies
III. Parameters and Methods for the Assessment of Toxicity
IV. Future Prospects
References
Author Index
Subject Index
- No. of pages: 562
- Language: English
- Edition: 1
- Published: January 1, 1977
- Imprint: Academic Press
- Hardback ISBN: 9780125983037
- Paperback ISBN: 9780124142824
- eBook ISBN: 9780323145985