GPCR Signaling in Cancer
- 1st Edition, Volume 145 - February 20, 2020
- Imprint: Academic Press
- Editor: Arun K. Shukla
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 0 2 3 0 - 2
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 0 2 3 1 - 9
GPCR Signaling in Cancer, Volume 145, the latest release in the Advances in Cancer Research series, highlights recent developments in the area of GPCRs and cancer biology. Chapter… Read more
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Request a sales quoteGPCR Signaling in Cancer, Volume 145, the latest release in the Advances in Cancer Research series, highlights recent developments in the area of GPCRs and cancer biology. Chapters included in this volume cover several GPCRs and their downstream effectors as case examples to highlight their fundamental understanding and therapeutic potential. Specific chapters address the Role of GRKs and beta-arrestins in cancer, Atypical GPCRs in cancer, the Role of a chemokine receptor (CCR) 5 in cancer, Targeting G protein-coupled receptors for therapeutics in cancer, Emerging GPCR signaling pathways in cancer, and more.
G protein-coupled receptors (GPCRs) constitute a large family of cell surface receptors which are involved in nearly every cellular and physiological event. These receptors can recognize a broad array of ligands and they are targeted by nearly one third of the currently prescribed drugs including anti-cancer therapeutics.
- Covers the latest concepts in GPCR signaling and their relevancy to cancer biology
- Presents new indications for anti-cancer therapeutic programs
- Includes sections on cross-talk and signaling networks of GPCRs and effectors in molecular oncology and therapeutics
Primary researchers and clinicians involved in molecular oncology research and cancer therapeutics
1. HERs Transregulation in Cancer Progression: From Discovery to 2020 and Beyond
Rakesh Kumar
2. RTKs in Cancer Biology
Paul Fisher
3. Advances in EGFR Biochemistry and Biology
Yosef Yarden
4. Mouse Models of RTKs/HERs: Lessons and Implications to Biology and Therapy
William Joseph Muller
5. MET Receptor in Oncology: From Biomarker to Therapeutic Target
Ravi Salgia
6. RTKs in Pathobiology of Head & Neck Cancer
Radhakrishna Pillai
7. HER2 or Nuclear HER/RTK in Cancer
Mien-Chie Hung
8. FLT3 in Hematopietic Malignancies: From Pathobiology to Therapeutics
Premkumar Reddy
9. Advances in IGF1R Biology and –directed Cancer Therapeutics
Douglas Yee
10. Advances in Bcr-Abl in Cancer Therapy and Biology
Nandini Verma
11. EphRs in Cancer Development and Progression
Renata Pasqualini
12. RTK-directed Clinical Advances: Trials and Treatments
Masakazu Toi
- Edition: 1
- Volume: 145
- Published: February 20, 2020
- No. of pages (Hardback): 164
- No. of pages (eBook): 164
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780128202302
- eBook ISBN: 9780128202319
AS
Arun K. Shukla
Dr. Arun K. Shukla is a world leader in the field of GPCR biology and he is currently a Professor in the Department of Biological Sciences and Bioengineering at the Institute of Technology, Kanpur in India. Dr. Shukla’s research program is focused on understanding the structure, function and regulation of G protein-coupled receptors with a long-term of designing novel therapeutics with minimized side-effects.
Affiliations and expertise
Indian Institute of Technology, Kanpur, IndiaRead GPCR Signaling in Cancer on ScienceDirect