Good and Bad Testosterone

1st Edition - November 6, 2023
Author: Ilpo Huhtaniemi
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 3 4 3 2 - 6
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 3 4 3 1 - 9

Good and Bad Testosterone is a unique reference to understand and learn about the biology and psychophysical aspects of this hormone.Unlike most other hormones, testostero… Read more

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Good and Bad Testosterone is a unique reference to understand and learn about the biology and psychophysical aspects of this hormone.
Unlike most other hormones, testosterone regulates not only the biological functions of the body but also many psychological functions. This wide spectrum of effects, influencing nearly all biological and behavioral features of a males, makes testosterone particularly interesting.
This book takes a historical approach to understanding testosterone. It provides is a comprehensive description of the functions of testosterone and its role in determining the biological, medical, psychological, behavioral, and cultural features of the male sex/gender and the male/female differences. Sex/gender issues are of great interest for a wide readership, including the general public and experts from various disciplines.

Cover image
Title page
Table of Contents
Copyright
Foreword
Acknowledgments
Acknowledgments to the Finnish edition
Acknowledgments to the English edition
Chapter 1 Introduction
Chapter 2 History of testosterone—From mysticism to molecule
Abstract
The principles of hormonal action begin to unfold
Race for isolation and unraveling the structure of testosterone
Causes and consequences of testosterone deficiency discovered; some milestones
From molecule to medicine
Solving the mechanism of androgen action
References
Chapter 3 Basics—The synthesis and actions of testosterone
Abstract
Endocrine glands and hormones
Biochemistry of testosterone
Regulation of testosterone synthesis
How much testosterone is needed?
Mechanism of testosterone action at the cellular level
The multitude of testosterone actions in the body
References
Chapter 4 How is testosterone measured and investigated?
Abstract
Immunoassays
Mass spectrometry
Issues to be considered in the measurement of testosterone
Research of testicular endocrine function
References
Chapter 5 Testosterone production and actions at different phases of life
Abstract
Fetal life
Newborn and minipuberty
Puberty
Adult life and senescence
References
Chapter 6 Testosterone and male sexual function
Abstract
Male sexual anatomy
Male sexual act
Does size matter?
Male sexual behavior
References
Chapter 7 Psychological effects of testosterone
Abstract
Sex differences in brain function
Cognitive functions
Testosterone and dominance
Testosterone in fathers and during social bonding
Testosterone and mental health
Diverse and unexpected behavioral effects of testosterone
References
Chapter 8 Testosterone and aggression
Abstract
What is aggression?
Examples from the animal kingdom
Aggression in men
Differences between male and female aggression
Testosterone, violence, and crime
References
Chapter 9 Sexual orientation, gender identity, and LGBTQ+
Abstract
The multifaceted concepts of sex and gender
The different phases of sexual differentiation
Testosterone and sexual orientation
Testosterone and gender identity
References
Chapter 10 Testosterone and risk-taking in stock market
Abstract
How are stock traders made?
Effect of testosterone and cortisol on risk-taking
Risk-taking in laboratory conditions
Risk-taking in animal experiments
Men and women as decision-makers
References
Chapter 11 Anabolic effects of testosterone
Abstract
Anabolic effects of testosterone from fetal period until puberty
Anabolic effects of testosterone in adult men
Effect of physical stress on testosterone
References
Chapter 12 Testosterone, sports, and doping
Abstract
What are the doping substances?
History of doping
Doping with anabolic steroids
Adverse effects of anabolic steroids
Doping control
Ho do athletes cheat in doping tests: Collected explanations
Female athletes’ testosterone: Difficult if not impossible equation
The doping saga of the DDR
References
Chapter 13 Why are men healthier but die younger than women?
Abstract
Health differences between men and women
Why are women more resilient than men?
Diseases occurring only in men
Diseases more common in men
Diseases where testosterone protects men
Sex difference in life expectancy
Mortality of men and women
Biological reasons for the sex difference in life expectancy
Behavioral and environmental effects on life expectancy
References
Chapter 14 Testosterone as elixir of life—A short history of quackery
Abstract
Charles-Édouard Brown-Séquard and the first odyssey of rejuvenation treatment
Eugen Steinach and the second odyssey of male rejuvenation
Serge Voronoff and the third odyssey of male rejuvenation
More steam: Voronoff's followers in the United States
Paul Niehans: Echoes from the past
What have we learned?
References
Chapter 15 Lack of testosterone or hypogonadism
Abstract
What is hypogonadism?
Different types of hypogonadism
Diagnosis of hypogonadism
Treatment of hypogonadism
Follow-up of testosterone treatment
Contraindications of testosterone treatment
References
Chapter 16 The aging man and testosterone
Abstract
Sexuality and fertility of the aging male
Does testosterone production decrease in men with aging?
Why does testosterone of some men decrease with aging?
Testosterone for old men—Real progress or a new wave of quackery?
Contraindications and risks of testosterone treatment in older men
References
Chapter 17 The good, the bad, and the ugly: Correct, questionable, and misuse of testosterone
Abstract
Testosterone use according to good clinical practice
Questionable use of testosterone
Misuse of testosterone
Testosterone preparations in clinical use
Anabolic steroids
Selective androgen receptor modulators
References
Chapter 18 Male pill—What’s the holdup?
Abstract
Why is a contraceptive method needed for men?
The currently available male contraception methods
New hormonal male contraceptive methods under development
Nonhormonal methods
Pharmacological contraception with targeted drugs
The future of male contraception
References
Chapter 19 Castration and eunuchs: Men without testosterone
Abstract
Long history of castration
Religious fanaticism and castration
Eunuchs of the Chinese court
Arab slave trade and castration
Mythology, history, and art
Medical effects of castration
Castration and life expectancy
Castration as medical treatment
References
Chapter 20 Women's testosterone
Abstract
Testosterone production in women
The wide spectrum of testosterone actions in women
When there is too much or too little testosterone
Is androgen action necessary for life?
Facts, fiction, and legends
References
Chapter 21 Conclusions
Subject Index
Name Index
Glossary
Abbreviations

Ilpo Huhtaniemi

Dr Ilpo Huhtaniemi is an Emeritus Professor of Reproductive Endocrinology in the Institute of Reproductive and Developmental Biology, Imperial College London (London, UK) and Emeritus Professor of Physiology at Department of Physiology, University of Turku (Turku, Finland). His clinical specialty is in chemical pathology. He is an author of about seven hundred peer-reviewed publications as well as several book chapters on basic and clinical reproductive endocrinology and laboratory diagnosis of endocrine diseases. He currently serves as an editorial board member for several academic journals, including as editor-in-chief of Molecular and Cellular Endocrinology (Elsevier). Dr. Huhtaniemi has also edited several books in the field of reproductive endocrinology and physiology. He has received many honours for his research activities, such as the NIH International Postdoctoral Research Fellow (Fogarty Foundation), Senior Fellowship of The Academy of Finland, Young Investigator Award of The American Society of Andrology, Matti Äyräpää Award of the Finnish Medical Society DUODECIM, Honorary Membership of The Romanian Academy of Medical Sciences, Doctor h.c. of Medical University of Lodz, Poland and Doctor h.c. of Albert Szent-György Medical University, Szeged, Hungary, The Egon Diczfalusy Foundation Lifetime Achievement Award, Iain McIntyre Medal (Queen Mary University, London), and Society for Endocrinology (UK), The European Medal. Named lectures: German Endocrine Society, The Berthold Medal and Prize Lecture; Australian Society for Reproductive Biology (The Goding Lecture); Nordic Association for Andrology (The Erik Blom Lecture); The American Society of Andrology (EAA Exchange Lecture). Dr. Huhtaniemi has been elected to The Finnish Academy of Science and Letters, The Academy of Medical Sciences, UK, and he is Knight, First Class, of the Order of the White Rose of Finland.

Affiliations and expertise

Department of Metabolism, Digestion and Reproduction, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, UK