Gold Nanoparticles for Drug Delivery

1st Edition - November 29, 2023
Editor: Prashant Kesharwani
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 9 0 6 1 - 2
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 9 0 6 2 - 9

Gold Nanoparticles for Drug Delivery discusses the synthesis and characterization of gold nanoparticles (AuNPs), presenting an historical introduction to the developments in the ar… Read more

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Gold Nanoparticles for Drug Delivery discusses the synthesis and characterization of gold nanoparticles (AuNPs), presenting an historical introduction to the developments in the area, discussing methods and characterization parameters, covering targeted delivery strategies, treatment of cancer, CNS conditions, infectious diseases, HIV/AIDS infection, wound healing and tissue regeneration, dentistry, gene delivery, and its photo properties used in diagnostic and therapies, and finally presenting regulatory aspects such as theranostic applications, vaccine development, toxicity, and the translation of research to marketable products.

This book is a complete reference for researchers in nanotechnology drug delivery and pharmaceutical disciplines. Researchers in pharmaceutical industries, especially those involved in the use of gold nanoparticles in the field of drug delivery, diagnosis, targeted and early therapies will also benefit from this book.

Cover image
Title page
Table of Contents
Copyright
Dedication
List of contributors
About the editor
Preface
Acknowledgments
Part A: Synthesis and characterization of gold nanoparticles for drug delivery
Chapter 1. History, introduction, and physiochemical properties of gold nanoparticles
Abstract
1.1 History of development of gold nanoparticles
1.2 Introduction
1.3 Various types of nanoparticles
1.4 Synthesis of various types of gold nanoparticle
1.5 Physicochemical properties of gold nanoparticles
1.6 Conclusion
References
Chapter 2. Green synthesis and characterization parameters of gold nanoparticles
Abstract
2.1 Introduction
2.2 Green synthesis of AuNPs
2.3 Characterization of AuNPs
2.4 Conclusions and future prospects
Acknowledgements
References
Chapter 3. Cellular interactions and design principles of glyco-gold nanoparticles for drug delivery applications
Abstract
3.1 Introduction
3.2 Synthesis methodologies of GAuNPs
3.3 Design principles of GAuNPs
3.4 Development of GAuNPs for drug delivery applications
3.5 Concluding remarks
References
Part B: Application of gold nanoparticles in drug delivery
Chapter 4. Targeting strategies using gold nanoparticles for efficient drug delivery
Abstract
4.1 Introduction
4.2 Passive targeting
4.3 Active targeting
4.4 Magnetic iron oxide cores
4.5 Small molecules
4.6 Peptides and proteins
4.7 DNA and RNA
4.8 Conclusions
References
Chapter 5. Gold nanoparticles for delivery of nucleic acid constructs for cancer treatment
Abstract
5.1 Introduction
5.2 Delivery of RNA using AuNP constructs for cancer therapy
5.3 DNA delivery via AuNP constructs
5.4 Conclusion and future prospects
References
Chapter 6. Theranostic gold nanoparticle-assisted tumor radiosensitization and imaging
Abstract
6.1 Introduction
6.2 Gold nanoparticle-assisted radiation therapy
6.3 Gold nanoparticle-based molecular imaging: X-ray fluorescence imaging
6.4 Conclusion
Acknowledgement
References
Chapter 7. Potential therapeutic role of gold nanoparticles in inflammatory diseases
Abstract
7.1 Introduction
7.2 Gold nanoparticles
7.3 Inflammation
7.4 Gold nanoparticles in the treatment of inflammatory diseases
References
Chapter 8. The use of gold nanoparticles in the treatment of neurodegenerative diseases
Abstract
8.1 Introduction
8.2 Parkinson’s disease
8.3 Alzheimer’s disease
8.4 Duchenne muscular dystrophy
8.5 Multiple sclerosis
References
Chapter 9. Gold nanoparticles for treatment of cerebral diseases
Abstract
9.1 Introduction
9.2 Blood-brain barrier
9.3 Gold nanoparticle for treatment of cerebral diseases
9.4 Brian disease diagnosis
9.5 Outlook and conclusion
Acknowledgment
References
Chapter 10. Gold nanoparticles for treatment of infectious diseases
Abstract
10.1 Introduction
10.2 Bacterial infection
10.3 Viral infection
10.4 Fungal infection
10.5 Parasitic infection
10.6 Conclusion and future prospects
Acknowledgments
References
Chapter 11. Gold nanoparticles as a recent nanocarrier against HIV/AIDS
Abstract
11.1 Introduction
11.2 Definition of AuNPs
11.3 AuNP synthesis
11.4 AuNP application in biomedicine
11.5 Nanotechnology approaches for HIV/AIDS therapy
11.6 Inhibition of HIV by AuNPs
11.7 AuNPs to improve HIV drug delivery
11.8 Recent breakthroughs in AuNP technology
11.9 Conclusion and future perspective
Acknowledgment
References
Chapter 12. Gold nanoparticles in tissue engineering and regeneration
Abstract
12.1 Introduction
12.2 Tissue regeneration
12.3 Heart
12.4 Skin
12.5 Bone
12.6 Neural tissues
12.7 Chemical synthesis
12.8 Future perspectives
12.9 Challenges
12.10 Conclusion
References
Chapter 13. Applications of gold nanoparticle in regenerative medicine
Abstract
13.1 Regenerative medicine and nanotechnology
13.2 Main characteristics of gold nanoparticle used in regenerative medicine
13.3 AuNP in regenerative medicine
13.4 Conclusion
References
Chapter 14. Gold nanoparticles in photodynamic and photothermal therapy
Abstract
14.1 Introduction
14.2 Photo-induced therapy
14.3 Versatility of AuNPs as multifunction photoactive tools
14.4 Limitations
References
Chapter 15. Polymeric gold nanoparticles for gene therapy
Abstract
15.1 Introduction
15.2 Gold nanoparticles synthesis
15.3 Characterization of gold nanoparticles
15.4 Role of ligand in nanoparticles stability
15.5 Surface functionalization of gold nanoparticles for gene delivery
15.6 Role of size and shapes of gold nanoparticles as nucleic acid delivery carrier
15.7 Stimuli-responsive gold nanoparticles in gene therapy
15.8 Gold nanoparticles-based theranostics
15.9 Conclusion and future perspective
References
Part C: Recent advances and regulatory aspects of gold nanoparticles
Chapter 16. Hybrid gold nanoparticles as advanced drug delivery and theranostics application
Abstract
16.1 Introduction
16.2 Hybrid AuNPs for drug delivery application
16.3 Hybrid AuNPs for theranostics application
16.4 Conclusion
References
Chapter 17. Application of gold nanoparticles in vaccine development
Abstract
17.1 Introduction
17.2 Synthesis of AuNPs
17.3 The Turkevich method
17.4 The Frens method
17.5 The Brust method
17.6 Characterization of AuNPs
17.7 Spectrophotometry
17.8 Dynamic light scattering
17.9 Electron microscopy
17.10 Functionalization of AuNPs
17.11 Physisorption
17.12 Chemisorption
17.13 Vaccine studies using AuNPs
17.14 Model antigens
17.15 Viral antigens
17.16 Bacterial or parasitic antigens
17.17 Cancer antigens
17.18 Recent studies on the safety of AuNPs and ongoing clinical trials
17.19 Perspectives and conclusive remarks
References
Chapter 18. Clinical translation of gold nanoparticles: obstacles and perspectives
Abstract
18.1 Introduction
18.2 Obstacles and failures
18.3 Standardization of research to enhance clinical translation
18.4 Concluding remark
References
Chapter 19. Conclusion and future perspective of gold nanoparticles
Abstract
19.1 Introduction
19.2 AuNPs—an important tool to treat various diseases
19.3 Theranostic applications of AuNPs and associated toxicity
19.4 Synthesis and characterization parameters of AuNPs
19.5 Targeting and uptaking of AuNPs for drug delivery
19.6 Conclusion and future prospects of AuNPs
Acknowledgement
References
Index

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Prashant Kesharwani