Glaucoma: A Neurodegenerative Disease of the Retina and Beyond: Part A
- 1st Edition, Volume 256 - September 21, 2020
- Imprint: Elsevier
- Editors: Giacinto Bagetta, Carlo Nucci
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 1 0 6 - 9
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 1 0 7 - 6
Glaucoma: A Pancitopatia of the Retina and Beyond, Volume 257, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volu… Read more
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Request a sales quoteGlaucoma: A Pancitopatia of the Retina and Beyond, Volume 257, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this volume include the Genetics of glaucoma, Artificial intelligence and deep learning in glaucoma detection and monitoring, The role of commensal microflora-induced T cells responses in glaucoma neurodegeneration, Retinal cell death in experimental glaucoma, Experimental and clinical evidence on the neuroprotective properties of Citicoline in glaucoma, Glaucoma neurodegeneration and myopia, Neuronal regeneration with pluripotent stem cells in glaucoma, and more.
- Covers all key aspects of current research on glaucoma
- Provides extensively referenced chapters, giving readers a comprehensive list of resources on topics covered
- Includes comprehensive and in-depth background information written in a clear form that is accessible to both specialists and non-specialists
Researchers, academics and all others interested in or involved in study of glaucoma
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter 1: Functional and morphological alterations in a glaucoma model of acute ocular hypertension
- Abstract
- 1: Introduction
- 2: Methods
- 3: Results
- 4: Discussion
- Financial support
- Chapter 2: Genetics of primary open-angle glaucoma and its endophenotypes
- Abstract
- 1: Introduction
- 2: Genome-wide association studies on POAG endophenotypes
- 3: Disc area and vertical cup-to-disc ratio (VCDR)
- 4: Intraocular pressure (IOP)
- 5: Summary
- Chapter 3: A broad perspective on the molecular regulation of retinal ganglion cell degeneration in glaucoma
- Abstract
- 1: Complexity of RGC degeneration in glaucoma
- 2: Injury of RGC axons at the optic nerve head
- 3: Molecularly distinct compartmentalized processes for RGC degeneration
- 4: Mitochondrial dysfunction, a key pathogenic event in RGC degeneration at different compartments
- 5: Glia-driven neuroinflammation, a widespread outcome promoting RGC degeneration
- 6: Molecular signaling for degeneration of RGC axons
- 7: Molecular signaling for RGC soma death
- 8: Loss of RGC synapses at dendrites and axon terminals
- 9: Conclusions
- Acknowledgments
- Chapter 4: The role of commensal microflora-induced T cell responses in glaucoma neurodegeneration
- Abstract
- 1: Introduction
- 2: Microbiota in neuroinflammation
- 3: Heat shock proteins in glaucomatous neurodegeneration
- 4: Interactions between T cells and microglia
- 5: Conclusion
- Chapter 5: The role of neuroinflammation in the pathogenesis of glaucoma neurodegeneration
- Abstract
- 1: Introduction
- 2: The link between neuroinflammation and oxidative stress in glaucoma neurodegeneration
- 3: Genetics and omics in glaucoma neuroinflammation
- 4: Update on uveitic glaucoma
- 5: Imaging methods for ocular inflammation and glaucoma
- 6: Clues in glaucoma neuroprotection
- 7: Closing remarks
- Acknowledgments
- Chapter 6: Microglial changes in the early aging stage in a healthy retina and an experimental glaucoma model
- Abstract
- 1: Introduction
- 2: Material and methods
- 3: Results
- 4: Discussion
- Acknowledgments
- Chapter 7: Molecular changes in glaucomatous trabecular meshwork. Correlations with retinal ganglion cell death and novel strategies for neuroprotection
- Abstract
- 1: Introduction
- 2: Oxidative stress
- 3: The Nrf2 and NF-κB systems
- 4: Aging
- 5: The aqueous humor proteome: Its importance in glaucoma
- 6: Neuroprotective strategies
- 7: Conclusions
- Acknowledgments
- Chapter 8: Effects of caloric restriction on retinal aging and neurodegeneration
- Abstract
- 1: Introduction
- 2: Glaucoma: An ocular neurodegenerative disease
- 3: Caloric restriction and fasting in brief
- 4: The effect of caloric restriction in retinal aging and neurodegeneration
- 5: Autophagy: Mechanism and function
- 6: Autophagy and glaucoma
- 7: The effect of caloric restriction on autophagy
- 8: Conclusion
- Chapter 9: Is stagnant cerebrospinal fluid involved in the pathophysiology of normal tension glaucoma
- Abstract
- 1: Summary
- Edition: 1
- Volume: 256
- Published: September 21, 2020
- No. of pages (Hardback): 232
- No. of pages (eBook): 232
- Imprint: Elsevier
- Language: English
- Hardback ISBN: 9780128211069
- eBook ISBN: 9780128211076
GB
Giacinto Bagetta
Giacinto Bagetta is Professsor of Pharmacology and works in the Department of Pharmacy, Health Science and Nutrition
at University of Calabria, Arcavata di Rende, Italy.
Affiliations and expertise
Professsor of Pharmacology, University of Calabria, Arcavata di Rende, ItalyCN
Carlo Nucci
Carlo Nucci is Professor of Ophthalmology in the Ophthalmology Unit, Department of Experimental Medicine at the University of Rome Tor Vergata, Italy.
Affiliations and expertise
Professor of Ophthalmology, Ophthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, ItalyRead Glaucoma: A Neurodegenerative Disease of the Retina and Beyond: Part A on ScienceDirect