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Elsevier

Genomic and Precision Medicine

Foundations, Translation, and Implementation

  • 3rd Edition - November 22, 2016
  • Latest edition
  • Editors: Geoffrey S. Ginsburg, Huntington F Willard
  • Language: English

Genomic and Precision Medicine: Foundations, Translation, and Implementation highlights the various points along the continuum from health to disease where genomic informati… Read more

Description

Genomic and Precision Medicine: Foundations, Translation, and Implementation highlights the various points along the continuum from health to disease where genomic information is impacting clinical decision-making and leading to more personalization of health care.

The book pinpoints the challenges, barriers, and solutions that have been, or are being, brought forward to enable translation of genome based technologies into health care. A variety of infrastructure (data systems and EMRs), policy (regulatory, reimbursement, privacy), and research (comparative effectiveness research, learning health system approaches) strategies are also discussed. Readers will find this volume to be an invaluable resource for the translational genomics and implementation science that is required to fully realize personalized health care.

Key features

  • Provides a comprehensive volume on the translation and implementation of biology into health care provision
  • Presents succinct commentary and key learning points that will assist readers with their local needs for translation and implementation
  • Includes an up-to-date overview on major ‘translational events’ in genomic and personalized medicine, along with lessons learned

Readership

Medical students, life sciences and engineering graduate students, advanced undergraduate students, residents and fellows working with any aspect of genomic research in the life sciences and/or medicine, educators, and translational scientists. This volume will also be of interest to translational researchers, implementation scientists, outcomes researchers, policy analysts and policy makers

Table of contents

1. Application of Human Genome Information to Clinical Practice

1a. Genome sequencing: new technologies, approaches, applications

1b. Clinical applications of whole-genome chromosomal microarray analysis

1c. Transcriptomics in the age of ultra high-throughput sequencing

1d. Quantitative Proteomics in Genomic Medicine

2. Translating genome information into clinical practice and human health

3. Big Data and Translational Bioinformatics Genomic and Personalized Medicine

3a. Biospecimen Banking linked to phenotype data

3b. Electronic Health Records

3c. Data Sharing and Privacy

4. Designing Genome-Based Clinical Studies

5. Developing the Evidence to Support Clinical Use Genomic Biomarkers as Diagnostics

5a. Strategies in the Adoption of Genome-Based Diagnostics

5b. Companion Diagnostics

6. Health Risk Assessment and Family History

7. Clinical Decision Support

8. Implementation Science and Integration into Healthcare Systems

9. Pharmacogenetics and Pharmacogenomics

10. Drug Repurposing and Repositioning

11. Point of Care Devices

12. Overview of Policy, Ethical and Social Considerations

13. Educational Issues and Strategies for Genomic Medicine:

13a. For Professionals

13b. For The Public

14. Regulation of Genomic Technologies

15. Economic Value of Genomic Medicine

16. Reimbursement

17. Impact of Patents on Genomic Medicine

Review quotes

"...I believe there is nothing similar on the market. This book is unique as a well-done and clearly presented compilation of information. It is easy to read and captures the inquisitive minds of readers. Further editions will be well received. Score: 98 - 5 Stars"—Doody's

Product details

  • Edition: 3
  • Latest edition
  • Published: November 22, 2016
  • Language: English

About the editors

GG

Geoffrey S. Ginsburg

Dr. Ginsburg is the founding Director of the Center for Applied Genomics & Precision Medicine in the Duke Institute for Genome Sciences & Policy. He is also Professor of Medicine and of Pathology at Duke University Medical Center, Professor of Biomedical Engineering at Duke Pratt School of Engineering, and Co-Director of the Duke Translational Medicine Institute.
Affiliations and expertise
Chief Medical and Scientific Officer, All of Us Research Program, National Institutes of Health, Bethesda, Maryland, USA

HW

Huntington F Willard

Huntington Willard is on the faculty of the Department of Human Genetics at the University of Chicago. Prior to this appointment, Willard was the President and Director of the Marine Biological Laboratory and Professor of Human Genetics at the University of Chicago. He was previously on the faculty at Duke University, where he was founding director of the university-wide Duke Institute for Genome Sciences & Policy from 2003 to 2014, the Nanaline H. Duke Professor of Genome Sciences, and the Arts & Sciences Professor of Biology & Genome Sciences.
Affiliations and expertise
Chief Scientific Officer, Genome Medical, Inc., South San Francisco, CA, USA

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