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Genome Editing for Neurodegenerative Diseases
From Concept to Clinical Trials
- 1st Edition - November 1, 2024
- Editors: Sandeep Kumar Singh, Amarish Kumar Yadav, Burkhard Poeggeler, George Perry
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 3 8 2 6 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 3 8 2 7 - 7
Genome Editing for Neurodegenerative Diseases: From Concept to Clinical Trials examines recent advances in neurodegenerative disease research and clinical challenges in practical… Read more
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Request a sales quoteGenome Editing for Neurodegenerative Diseases: From Concept to Clinical Trials examines recent advances in neurodegenerative disease research and clinical challenges in practical applications. With an emphasis on genome editing tools such as ZFNs, TALENSs and CRISPR-Cas, this book sheds light on the possibilities to counteract genetic and neurodegenerative diseases. It will be of interest to researchers in neuroscience and biopharmaceuticals, as well as clinicians specializing in neurodegenerative diseases.
- Covers basic mechanisms of genome-editing tools and their therapeutic potential
- Highlights current research progress and therapeutic strategies to use genome-editing tools against neurodegenerative diseases
- Includes research on genome-editing tool development, from basic concept to clinical trials
Researchers in neuroscience, biopharmaceuticals, clinicians working with neurodegenerative diseases, Potential overlap for graduate students studying neurodegenerative diseases and neurodegenerative disease therapy
1. Overview of genome editing tools and general neurodegenerative diseases
Dr. Ricardo B. Maccioni (Chile)
2. Genetic and molecular basis of neurodegenerative diseases
Sandeep Kumar Singh (India).
3. Genome editing tools: Principles, structures, and mechanisms
Saurabh Srivastav (USA).
4. Role of genome editing tools in the establishment of neurodegenerative disease models: In-vitro and In-vivo studies
Dr. Claudio Cuello (Canada)
5. Innovation of CRISPR/Cas systems and genome editing approaches for neurodegenerative diseases
Dr. Michel Goedert (UK).
6. Use of CRISPR systems in genetic screening to investigate neurodegenerative diseases
Sandeep Kumar Singh (India)
7. Epigenetic manipulation and genes regulation using CRISPR/Cas system for neurodegenerative diseases
Yogesh Dhuria (India)
8. Transgene delivery systems: Viral, non-viral and other methods for CNS
Hareram Birla (USA)
9. Gene-therapies for neurodegenerative diseases: current knowledge and challenges
Amarish Kumar Yadav (USA)
10. Gene therapies under clinical trials for neurodegenerative diseases
M. P. Singh (India)
11. Clinical challenges and future prospective in use of gene-editing tools as neurotherapeutics
Dr. Burkhard Poeggeler (Germany)
Dr. Ricardo B. Maccioni (Chile)
2. Genetic and molecular basis of neurodegenerative diseases
Sandeep Kumar Singh (India).
3. Genome editing tools: Principles, structures, and mechanisms
Saurabh Srivastav (USA).
4. Role of genome editing tools in the establishment of neurodegenerative disease models: In-vitro and In-vivo studies
Dr. Claudio Cuello (Canada)
5. Innovation of CRISPR/Cas systems and genome editing approaches for neurodegenerative diseases
Dr. Michel Goedert (UK).
6. Use of CRISPR systems in genetic screening to investigate neurodegenerative diseases
Sandeep Kumar Singh (India)
7. Epigenetic manipulation and genes regulation using CRISPR/Cas system for neurodegenerative diseases
Yogesh Dhuria (India)
8. Transgene delivery systems: Viral, non-viral and other methods for CNS
Hareram Birla (USA)
9. Gene-therapies for neurodegenerative diseases: current knowledge and challenges
Amarish Kumar Yadav (USA)
10. Gene therapies under clinical trials for neurodegenerative diseases
M. P. Singh (India)
11. Clinical challenges and future prospective in use of gene-editing tools as neurotherapeutics
Dr. Burkhard Poeggeler (Germany)
- No. of pages: 400
- Language: English
- Edition: 1
- Published: November 1, 2024
- Imprint: Academic Press
- Paperback ISBN: 9780443238260
SS
Sandeep Kumar Singh
Dr. Sandeep Kumar Singh is the Founder President of Indian Scientific Education and Technology (ISET) Foundation. He is researcher and neuroscientist with a strong background in Biochemistry and Biomedicine. He has a Ph.D. degree in Biotechnology. His research interests are in neurodegenerative diseases and has ~9 years of experience and worked as Postdoctoral Scholar at Neurobiology Department, The University of Chicago, USA.
He’s a member of editorial boards of several international journals related to field of neuroscience, the member of several scientific societies. Dr. Singh has been appointed as Bentham Ambassador by Bentham Science Publisher (USA). He is a speaker at several scientific national and international conferences/symposium/workshops in India and abroad.
Affiliations and expertise
Indian Scientific Education and Technology Foundation, Krishna Bhawan, Nilmatha Lucknow, Uttar Pradesh, IndiaAY
Amarish Kumar Yadav
Dr. Amarish K Yadav is a postdoctoral research scholar at North Carolina State University. His current research interest is developing gene-drive systems using CRISPR/Cas9 in Drosophila suzukii. After obtaining his master’s degree in biotechnology, he was awarded his Ph.D. from Banaras Hindu University in 2017. He has worked in collaboration with many neuroscientists and researchers to understand the molecular mechanisms of Alzheimer’s and Parkinson’s diseases progression and therapeutics. Dr. Yadav has published his research findings in peer-reviewed journals and has also authored a book chapter on neurodegenerative diseases modeling in drosophila. Dr. Yadav has participated and presented his research work at various national and international conferences and symposia.
Affiliations and expertise
Dept. of Entomology and Plant Pathology, North Carolina State University, Raleigh, NC, USABP
Burkhard Poeggeler
Dr. Burkhard Poeggeler is affiliated with the Georg-August-University Göttingen and works primarily on the biochemistry and pharmacology of regeneration by antioxidant protection and trophic prosurvival signaling. His research focusses on bioenergetic agents such as nitric oxide and on redox regulation such as neurovascular coupling. Together with many other distinguished scientists he investigates the unique nootropic, neurotrophic and neuroprotective activity of melatonin and related tryptophan metabolites based on their potent antioxidant, anti-inflammatory antiamyloidogenic effects such as amyloid clearance by the glymphatic system, the connective tissue, the interstitium and the gastrointestinal tract. Based on the exploration of these protective agents, he works on developing new possibilities to extend human health and life span. He is widely published with over 120 PubMed listed publications.
Affiliations and expertise
Department of Biology and Psychology, Georg-August-University Göttingen, GermanyGP
George Perry
Dr. George Perry, Ph.D. Professor of Biology and Chemistry
Semmes Foundation Distinguished University Chair in Neurobiology
He is a neuroscientist known for his work on neuronal oxidation of nucleic acids in Alzheimer's disease. He is distinguished as one of the top Alzheimer’s disease researchers with over 1000 publications, won numerous awards, and is one of the top 100 most-cited scientists.
Affiliations and expertise
Department of Biology, The University of Texas at San Antonio, University of Texas, San Antonio, TX, USA